Distribution of distant metastases from newly diagnosed non-small cell lung cancer

Quint, Leslie E.; Tummala, Srinivas; Brisson, Louis J.; Francis, Isaac R.; Krupnick, Alexander S.; Kazerooni, Ella A.; Iannettoni, Mark D.; Whyte, Richard I.; Orringer, Mark B.

doi:10.1016/0003-4975(96)00220-2

Cited by 299 publications

(204 citation statements)

References 14 publications

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“…The reported frequency of metastasis at the time of diagnosis of NSCLC has varied from 11% to 36%, and the common metastatic sites include the liver, adrenal gland, brain, bone, kidney and abdominal lymph nodes (2,3). The other unusual metastatic sites that have been reported are the stomach, pancreas, small bowel, arteriovenous hemangioma, choroid plexus, muscle, umbilicus and penis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Metachronous Metastasis to the Breast from Non-Small Cell Lung Carcinoma

et al. 2010

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I n t r o d u c t i o nNon-small cell lung cancer (NSCLC) accounts for approximately 75% to 80% of all the types of lung cancer, and it is the leading cause of cancer-related deaths worldwide (1). While small cell lung cancer can metastasize to nearly all the organs, metastasis from NSCLC is most commonly seen in the liver, adrenal glands, bone, brain, kidney and abdominal lymph nodes.Breast metastases from an extramammary primary tumor, including NSCLC, are very rarely reported, with the incidence being 0.5% to 3% of all the breast malignancies. The prognosis of these patients is poor. We report here on a case of a 42-year-old woman with metastasis to the breast from adenocarcinoma of the lung. Breast metastases from an extramammary primary tumor are very rare and the prognosis for such patients is generally poor. We report here on a case of a 42-year-old female with metastasis of non-small cell lung cancer to the breast, and she is now being followed up on an outpatient basis. In 2004, she presented with a solitary pulmonary nodule in the left lung, and this lesion had been noted to have gradually increased in size over time. The final pathological diagnosis was adenocarcinoma, and the diagnosis was made by performing percutaneous needle aspiration and lobectomy of the left upper lobe. Adjuvant chemotherapy and radiotherapy were given. Unfortunately, a nodule in the left breast was noted three years later, and metastatic non-small-cell lung cancer to the breast was diagnosed by excisional biopsy. Making the correct diagnosis to distinguish a primary breast carcinoma from a metastatic one is important, because the therapeutic plan and outcome for these two types of cancer are quite different. C a s e R e p o r t

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Section: Discussionmentioning

confidence: 99%

A Case of Metachronous Metastasis to the Breast from Non-Small Cell Lung Carcinoma

et al. 2010

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“…QUINT et al [117], found distant metastases in 21% of all NSCLC patients. Relative frequencies were brain 10%, bone 7%, liver 5% and adrenals 3%.…”

Section: Metastatic Statusmentioning

confidence: 96%

Diagnostic imaging of lung cancer

Hollings¹,

Shaw²

2002

Eur Respir J

124

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Carcinoma of the bronchus is the most common malignancy in the Western world. It is also the leading cause of cancer-related death accounting for 32% of all cancer deaths in males and 25% in females [1]. In the USA it causes more deaths than cancers of the colon, breast and prostate combined [2]. Disappointingly, in a recent UK survey of improvements in cancer survival [3], carcinoma of the bronchus showed the smallest percentage reduction in the number of deaths avoided between 1981-1990 (0.2%). This compares badly with breast (11% reduction) and melanoma (32%). The overall 5-yr survival for lung cancer diagnosed between 1986-1990 was only 5.3% (against 66% for breast and 76% for melanoma). It is on this background that the radiologist remains actively employed in the detection, diagnosis, staging and review of this common malignancy.

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“…The most commonly involved sites are the liver (33-40%), abdominal lymph nodes (29%), adrenal glands (18-38%), bones (19-33%), brain (15-43%) and kidneys (16-23%) (16). In general, hematogenous skeletal muscle metastasis is rare and the metastasis of lung cancer is even rarer, although it is the most common source (17).…”

Section: Discussionmentioning

confidence: 99%

Non-small cell lung cancer with concomitant intramuscular myxoma of the right psoas mimicking intramuscular metastasis: A case report and literature review

et al. 2015

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Abstract. Intramuscular myxoma (IMM) as a rare soft-tissue tumor arising from the muscles is completely benign. When IMM accompanies malignance, it may be misdiagnosed as muscle metastasis, and for this extremely rare concurrence, the subsequent treatment would vary accordingly. The current study presents, to the best of our knowledge, the first case of non-small cell lung cancer (NSCLC) concomitant with IMM mimicking skeletal muscle metastasis. A 64-year-old female was hospitalized with a history of chest discomfort and right lumbar pain that had persisted for four months. The computed tomography scan showed a lesion in the left upper lobe of the lung and the right psoas, respectively. Serum biomarkers for NSCLC were abnormal. A presumptive clinical diagnosis was compatible with left NSCLC and right psoas muscle metastasis (cT2aN3M1b, stage Ⅳ). Stage Ⅳ lung cancer would receive palliative treatment. However, the final diagnosis of synchronous left lung squamous cell carcinoma (cT2aN3M0, stage ⅢB) and IMM in the right psoas was confirmed by biopsy. The patient therefore underwent definitive chemoradiotherapy for lung carcinoma, and conservative treatment, including analgesics, for IMM. The diagnosis process for a malignant neoplasm concomitant with IMM is not straightforward due to a lack of clinical experience, and it significantly affects the tumor staging and subsequent treatment strategy. The present case suggests that IMM should be included in the differential diagnosis when an abnormal intramuscular lesion concomitant with malignancy is identified. The value of histopathological diagnosis prior to definitive treatment also requires highlighting.

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Distribution of distant metastases from newly diagnosed non-small cell lung cancer

Cited by 299 publications

References 14 publications

A Case of Metachronous Metastasis to the Breast from Non-Small Cell Lung Carcinoma

A Case of Metachronous Metastasis to the Breast from Non-Small Cell Lung Carcinoma

Diagnostic imaging of lung cancer

Non-small cell lung cancer with concomitant intramuscular myxoma of the right psoas mimicking intramuscular metastasis: A case report and literature review

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