Distribution of elastic fibers in the head and neck: a histological study using late-stage human fetuses

Kinoshita, Hideaki; Umezawa, Taishi; Omine, Yuya; Kasahara, Masaaki; Rodríguez‐Vázquez, José Francisco; Murakami, Gen; Abe, Shinichi

doi:10.5115/acb.2013.46.1.39

Cited by 20 publications

(12 citation statements)

References 41 publications

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“…The computer analysis may not able to discriminate the differences between sinusoidal and arterial endothelium. EM staining enabled us to identify unpaired arteries by detecting smooth muscle and elastic fibers . Furthermore, we identified sinusoid‐like microvessels in approximately 15% of all cases in this study.…”

Section: Discussionmentioning

confidence: 62%

Microvessel density in hepatocellular carcinoma: Prognostic significance and review of the previous published work

Murakami¹,

Kasajima²,

Kawagishi

et al. 2015

Hepatology Research

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Section: Discussionmentioning

confidence: 62%

Microvessel density in hepatocellular carcinoma: Prognostic significance and review of the previous published work

Murakami¹,

Kasajima²,

Kawagishi

et al. 2015

Hepatology Research

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“…The number of elastic fibers was found to be larger in the peritoneum than in the adjacent fascial structures [ 11 , 12 ]. Because of the pleural and/or peritoneal remnants in the mesoesophagus, the esophageal hiatus seems to carry elastic fibers at the 10th week [ 13 ], much earlier than other tissues [ 14 ]. Surgeons have been interested in the morphology of the phrenoesophageal membrane (=the phrenicoesophageal ligament), a dome-like membrane surrounding the lower thoracic esophagus just above the esophageal hiatus (e.g., St Peter et al [ 15 ]).…”

Section: Discussionmentioning

confidence: 99%

Mesoesophagus and other fascial structures of the abdominal and lower thoracic esophagus: a histological study using human embryos and fetuses

et al. 2014

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A term "mesoesophagus" has been often used by surgeons, but the morphology was not described well. To better understand the structures attaching the human abdominal and lower thoracic esophagus to the body wall, we examined serial or semiserial sections from 10 embryos and 9 fetuses. The esophagus was initially embedded in a large posterior mesenchymal tissue, which included the vertebral column and aorta. Below the tracheal bifurcation at the fifth week, the esophagus formed a mesentery-like structure, which we call the "mesoesophagus," that was sculpted by the enlarging lungs and pleural cavity. The pneumatoenteric recess of the pleuroperitoneal canal was observed in the lowest part of the mesoesophagus. At the seventh week, the mesoesophagus was divided into the upper long and lower short parts by the diaphragm. Near the esophageal hiatus, the pleural cavity provided 1 or 2 recesses in the upper side, while the fetal adrenal gland in the left side was attached to the lower side of the mesoesophagus. At the 10th and 18th week, the mesoesophagus remained along the lower thoracic esophagus, but the abdominal esophagus attached to the diaphragm instead of to the left adrenal. The mesoesophagus did not contain any blood vessels from the aorta and to the azygos vein. The posterior attachment of the abdominal esophagus seemed to develop to the major part of the phrenoesophageal membrane with modification from the increased mass of the left fetal adrenal. After postnatal degeneration of the fetal adrenal, the abdominal esophagus might again obtain a mesentery. Consequently, the mesoesophagus seemed to correspond to a small area containing the pulmonary ligament and aorta in adults.

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“…In addition, using elastica-Masson staining (a variation of Masson-Goldner staining), we examined whether or not the fetal pleura contains elastic fibers. According to Kinoshita et al [ 8 ], who demonstrated initial appearance of elastic fibers in the fetal head and neck, we expected to find elastic fibers in the lung after gestational week 20. Consequently, the aim of this study was to describe the fetal pulmonary pleura in relation to the lung surface morphology.…”

Section: Introductionmentioning

confidence: 96%

Development of the pulmonary pleura with special reference to the lung surface morphology: a study using human fetuses

et al. 2018

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In and after the third trimester, the lung surface is likely to become smooth to facilitate respiratory movements. However, there are no detailed descriptions as to when and how the lung surface becomes regular. According to our observations of 33 fetuses at 9–16 weeks of gestation (crown-rump length [CRL], 39–125 mm), the lung surface, especially its lateral (costal) surface, was comparatively rough due to rapid branching and outward growing of bronchioli at the pseudoglandular phase of lung development. The pulmonary pleura was thin and, beneath the surface mesothelium, no or little mesenchymal tissue was detectable. Veins and lymphatic vessels reached the lung surface until 9 weeks and 16 weeks, respectively. In contrast, in 8 fetuses at 26–34 weeks of gestation (CRL, 210–290 mm), the lung surface was almost smooth because, instead of bronchioli, the developing alveoli faced the external surfaces of the lung. Moreover, the submesothelial tissue became thick due to large numbers of dilated veins connected to deep intersegmental veins. CD34-positive, multilayered fibrous tissue was also evident beneath the mesothelium in these stages. The submesothelial tissue was much thicker at the basal and mediastinal surfaces compared to apical and costal surfaces. Overall, rather than by a mechanical stress from the thoracic wall and diaphragm, a smooth lung surface seemed to be established largely by the thick submesothelial tissue including veins and lymphatic vessels until 26 weeks.

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Distribution of elastic fibers in the head and neck: a histological study using late-stage human fetuses

Cited by 20 publications

References 41 publications

Microvessel density in hepatocellular carcinoma: Prognostic significance and review of the previous published work

Microvessel density in hepatocellular carcinoma: Prognostic significance and review of the previous published work

Mesoesophagus and other fascial structures of the abdominal and lower thoracic esophagus: a histological study using human embryos and fetuses

Development of the pulmonary pleura with special reference to the lung surface morphology: a study using human fetuses

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