Distribution of erb‐b2, erb‐b3, and erb‐b4 in the developing avian nervous system

Francoeur, J. R.; Richardson, P. M.; Dunn, Robert; Carbonetto, Salvatore

doi:10.1002/jnr.490410614

Cited by 22 publications

(11 citation statements)

References 31 publications

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“…Alternatively, one can hypothesize that in addition to signaling between individual SC, SC can also communicate with other cells which also express erb-B receptors such as neurons (Mason et al, 1993;Francoeur et al, 1995). This would add another dimension to the signaling which occurs between neurons and glial cells.…”

Section: Functions Of Neuregulins In Scmentioning

confidence: 96%

Cultured neonatal schwann cells contain and secrete neuregulins

et al. 1996

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Section: Functions Of Neuregulins In Scmentioning

confidence: 96%

Cultured neonatal schwann cells contain and secrete neuregulins

et al. 1996

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“…ErbB4 is predominantly expressed in brain, heart, and skeletal muscle (37). ErbB4 was also shown to be broadly distributed in the brains of chicken embryos (E14 and E17, predominantly in neurons) (38), in rat retina cultures (39), at neuromuscular synapses (44), but not in cultured human and rat Schwann cells (40,41). Recently, ErbB4 was found to colocalize with GABA ϩ cells (42).…”

Section: Fig 2 Multi-tissue Northern Blot Analysis Of Nrg3 (A)mentioning

confidence: 99%

Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4

Zhang¹,

Sliwkowski²,

Mark³

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

357

271

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We describe the identification of Neuregulin-3 (NRG3), a novel protein that is structurally related to the neuregulins (NRG1). The NRG1͞neuregulins are a diverse family of proteins that arise by alternative splicing from a single gene. These proteins play an important role in controlling the growth and differentiation of glial, epithelial, and muscle cells. The biological effects of NRG1 are mediated by receptor tyrosine kinases ErbB2, ErbB3, and ErbB4. However, genetic studies have suggested that the activity of ErbB4 may also be regulated in the central nervous system by a ligand distinct from NRG1. NRG3 is predicted to contain an extracellular domain with an epidermal growth factor (EGF) motif, a transmembrane domain, and a large cytoplasmic domain. We show that the EGF-like domain of NRG3 binds to the extracellular domain of ErbB4 in vitro. Moreover, NRG3 binds to ErbB4 expressed on cells and stimulates tyrosine phosphorylation of this receptor. The expression of NRG3 is highly restricted to the developing and adult nervous system. These data suggest that NRG3 is a novel, neural-enriched ligand for ErbB4.

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“…In addition, erbB-2 and erbB-4 have been reported in neurons of the developing chick nervous system; however, erbB-3 was found only in glial cells [29]. In contrast, we now report that erbB-2, erbB-3, and erbB-4 are all expressed in developing DRG neurons.…”

Section: Discussionmentioning

confidence: 80%

Developmental Regulation of Neuregulin1 Isoforms and erbB Receptor Expression in Intact Rat Dorsal Root Ganglia

et al. 2008

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Neuregulins (NRGs) are a family of growth factors which bind to the erbB family of tyrosine kinase receptors. The exact nature and interaction of specific NRG isoforms and erbB receptors that occur during the development of the nervous system have not been reported. In order to better understand the role that different NRG isoforms and erbB receptors play in the differentiation, proliferation, and survival of neurons and glial cells, we isolated protein and mRNA from dorsal root ganglia of rat pups between embryonic day (E) 13 and postnatal day (P) 15. The relative expression levels of the NRGs and erbB receptors for the different time points were compared using both Western and RT-PCR analyses. NRG1-type1alpha protein levels were highest at E-13 and then decreased by approximately 40% and remained constant through P-15. In contrast, mRNA levels for NRG1-type1alpha remained constant from E-15 to P-15. The protein levels for NRG1-type 1beta were similar to NRG1-type1alpha at E-13 with an approximate 40% increase in the levels at E-15 and E-17 followed by a decrease to E-13 levels for the remainder of the developmental time periods. The mRNA levels for NRG1-type1beta remained constant from E-15 to P-15. The protein and mRNA expression patterns for each erbB receptor were distinctive. The protein levels for erbB-2 were highest at E-19 while erbB-3 levels were highest at E-17 and E-18. ErbB-4 protein levels were highest at E-13 and decreased through P-15. The developmental pattern for erbB-2 and erbB-4 mRNA levels had no relation to that of the corresponding protein levels while the mRNA levels for erbB-3 were highest at E-17 and E-18 similar to the pattern observed for the erbB-3 protein levels. We concluded that both NRG and erbB expression in dorsal root ganglia are mostly translationally controlled and that NRG1 isoforms and their erbB receptors are not coordinately regulated.

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Distribution of erb‐b2, erb‐b3, and erb‐b4 in the developing avian nervous system

Cited by 22 publications

References 31 publications

Cultured neonatal schwann cells contain and secrete neuregulins

Cultured neonatal schwann cells contain and secrete neuregulins

Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4

Developmental Regulation of Neuregulin1 Isoforms and erbB Receptor Expression in Intact Rat Dorsal Root Ganglia

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