Distribution of flavonoids in Fagonia thebaica complex

Al-Wakeel, S.A.M.; El-Garf, Ibrahim A.; Saleh, Nabiel A.M.

doi:10.1016/0305-1978(88)90118-4

Cited by 17 publications

(4 citation statements)

References 2 publications

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“…The residue was dissolved in isopropanol and subjected to paper chromatography using ethyl acetate: pyridine: water 12: 5: 4 and benzene: n-butanol: pyridine: water 1: 5: 3: 3 as developing solvents with authentic references from different sugars. The chromatograms were visualized by spraying with aniline phthalate [16,17] and heated at 105ºC for a few minutes, their data were identical to those previously reported [18,19].…”

Section: Complete Acid Hydrolysissupporting

confidence: 74%

Secondary metabolites and Biological activities of Allium porrum L. attack Ehrlich ascites carcinoma in mice

Elhagrasi

Mahmoud

Foda³

et al. 2019

Egypt. J. Chem.

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A LLIUM vegetables have been recorded to be used in many medical remedies for protection and fighting diseases. The aim of the study is to investigate the phenolic compounds of methanol extract of Allium porrum L. aerial parts (MEAP) and introduce the methanolic extract as a candidate for the treatment of cancer in vivo as well as explore its antitumor mechanisms in attacking tumor cells at the molecular level. Isolation of phenolic and flavonoid compounds by column chromatography has been carried out. They were purified by Sephadex LH-20, and the structures were established with the aid of spectroscopic methods (UV, EI/MS, ESI/MS, 1 H-NMR, and 13 C-NMR spectroscopy). A total of 45 female Swiss albino mice were divided into five groups. One group represents the normal control. The four remaining groups were divided as follows: two groups were injected with Ehrlich ascites carcinoma (EAC) cells intraperitoneally and the other two were injected intramuscularly (to form solid tumor), representing the positive nontreated groups. One group from each model was administrated orally the extract at a dose of 300 mg/kg body weight 3 days weekly for 21 days after 24 h from the intraperitoneal or intramuscular injection of EAC cells. The influence of the extract on the apoptotic proteins were tested in EAC cells and in solid tumor of the treated groups compared with the nontreated ones. Eleven phenolic and flavonoid compounds were isolated from the aerial parts of methanol extract of A. porrum L., and characterized as follows: quercetin-3acid, and gallic acid. The gene expressions of caspase-3, Bax, and Bcl2 proteins and DNA fragmentation test were performed in the EAC cells. Hematological profile was conducted on mice's blood in addition to the Immuno-histochemical determination of P53 protein in solid tumors. MEAP has abundant phenolic compounds. It exhibits tumor suppressing mechanisms through the coordination between the apoptic proteins and DNA fragmentation in the EAC or solid cancer cells. MEAP is suggested to be a potent anticancer agent.

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Section: Complete Acid Hydrolysissupporting

confidence: 74%

Secondary metabolites and Biological activities of Allium porrum L. attack Ehrlich ascites carcinoma in mice

Elhagrasi

Mahmoud

Foda³

et al. 2019

Egypt. J. Chem.

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“…2005), Fagonia spp. (Al‐Wakeel, El‐Garf & Saleh 1988) and katsura tree (Wang, Duan & Zhou 1999). Flavonoids are also known to have diverse functions throughout the process of plant development, as colouring substances of flowers and seeds, as defense compounds and as signalling molecules in reproduction, pathogenesis and symbiosis (Shirley 1996).…”

Section: Discussionmentioning

confidence: 99%

Deep supercooling xylem parenchyma cells of katsura tree (Cercidiphyllum japonicum) contain flavonol glycosides exhibiting high anti‐ice nucleation activity

Kasuga

Hashidoko

Nishioka

et al. 2008

Plant Cell & Environment

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Xylem parenchyma cells (XPCs) of boreal hardwood species adapt to sub-freezing temperatures by deep supercooling to maintain a liquid state of intracellular water near -40°C. Our previous study found that crude xylem extracts from such tree species exhibited anti-ice nucleation activity to promote supercooling of water. In the present study, thus, we attempted to identify the causative substances of supercooling. Crude xylem extracts from katsura tree (Cercidiphyllum japonicum), of which XPCs exhibited deep supercooling to -40°C, were prepared by methanol extraction. The crude extracts were purified by liquid-liquid extraction and then by silica gel column chromatography. Although all the fractions obtained after each purification step exhibited some levels of anti-ice nucleation activity, only the most active fraction was retained to proceed to the subsequent level of purification. High-performance liquid chromatography (HPLC) analysis of a fraction with the highest level of activity revealed four peaks with high levels of anti-ice nucleation activity in the range of 2.8-9.0°C. Ultraviolet (UV), mass and nuclear magnetic resonance (NMR) spectra revealed that these four peaks corresponded to quercetin-

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“…Similarly, F. thebaica complex major class of flavonoids was flavonol-O-glycoside. Implied as quercetin 3,7-diglucoside and 3-rutinoside, isorhamnetin 3-rutinoside, 3-glucoside and 3,7-diglucoside, in addition to herbacetin 8-rutinoside as well as the 3-rutinoside and 3-glucoside of herbacetin 8-methyl ether [46] . The previous literature indicated that isorhamnetin 3,7diglycosides were abundant in F. tenuifolia, F. critica, F. sinaica, and partly F. indica complexes while lacking from the F.arabica [13,43] .…”

Section: Flavonoidsmentioning

confidence: 99%

“…The previous literature indicated that isorhamnetin 3,7diglycosides were abundant in F. tenuifolia, F. critica, F. sinaica, and partly F. indica complexes while lacking from the F.arabica [13,43] . In addition to isorhamnetin 3, 7-diglycosides, F. tenuifolia extract is rich in 3, 7-diglucosides of quercetin and isorhamnetin 3-glucoside, together with a trace amount of quercetin 3-rutinoside and a partially identified quercetin 3diglycoside [43,46] . As mentioned before The F. glutinosa complex includes two species, namely F. microphylla Pomel and, F glutinosa Del.…”

Section: Flavonoidsmentioning

confidence: 99%

The species of genus fagonia in Libya: (A comprehensive review)

Alamami¹,

Elshibani²,

Elremali³

et al. 2022

J Pharmacogn Phytochem

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The Plants of the genus Fagonia have been broadly utilized as adjunctive therapy, to treat several conditions involving high fever, diabetes, asthma, stoma chache, dental pain, and renal problems using their aqueous extracts as medicines. This genus is a valuable source that comprises a variety of Triterpenes, flavonoids, and Saponins. The herbal chemistry as well as the biological action of Fagonia species have been a candidate for many researchers. The in vivo pharmacological screening of their extracts has manifested some other significant properties such as cytotoxic and anti-cancer activity. This review study has gathered the important research that has been carried out on the species that grow in Libya. It includes an exhaustive survey of literature about the medicinal value and the bioactivities of various extracts obtained from these Fagonia species using references from major databases.

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Distribution of flavonoids in Fagonia thebaica complex

Cited by 17 publications

References 2 publications

Secondary metabolites and Biological activities of Allium porrum L. attack Ehrlich ascites carcinoma in mice

Secondary metabolites and Biological activities of Allium porrum L. attack Ehrlich ascites carcinoma in mice

Deep supercooling xylem parenchyma cells of katsura tree (Cercidiphyllum japonicum) contain flavonol glycosides exhibiting high anti‐ice nucleation activity

The species of genus fagonia in Libya: (A comprehensive review)

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