Distribution of gamma-aminobutyric acid, glycine, glutamate and aspartate in the cochlear nucleus of the rat.

Godfrey, Donald A.; Carter, Joyce A.; Lowry, Oliver H.; Matschinsky, Franz M.

doi:10.1177/26.2.624832

Cited by 108 publications

(28 citation statements)

References 18 publications

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“…The preponderance of receptor in these nuclei correlated well with the known levels of inhibitory function and, in the case of the cochlear nucleus, the levels of glycine (Godfrey et al, 1977(Godfrey et al, , 1978. In AVCN, LSO, and ICC there was a nonuniform distribution of binding that was aligned with the known tonotopic axes.…”

Section: Functional Implicationsmentioning

confidence: 63%

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Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil

et al. 1987

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The concentration and relative distribution of glycine receptors were determined for gerbil brain stem auditory nuclei using 3H-strychnine and quantitative autoradiographic techniques. Significant binding was observed in the anteroventral cochlear nucleus, the dorsal cochlear nucleus, the lateral superior olivary nucleus, and the inferior colliculus. A non-uniform distribution of binding was seen in 3 of these nuclei, such that the greatest concentration of glycine receptors was located in the high-frequency regions. An analysis of neuron soma density suggested that the amount of post-synaptic membrane could partially explain the distribution of receptor.

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Section: Functional Implicationsmentioning

confidence: 63%

“…It is not surprising that 3H-SN binding is greatest in this auditory region, as is the concentration of glycine (Godfrey et al, 1977(Godfrey et al, , 1978. Preliminary iontophoretic results indicate that glycine is a potent inhibitor of tone-evoked activity in the DCN (Caspary et al, 1985).…”

Section: Functional Implicationsmentioning

confidence: 99%

Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil

et al. 1987

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“…Since CN afferents to the LSO are glutamatergic (Caspary and Faingold, 1989;Godfrey et al, 1978;Helfert et al, 1992;Wu and Kelly, 1992), it is possible that glutamate release is decreased following bilateral ablation, resulting in higher than normal glycine receptor aggregation. Another possibility is that degeneration of CN afferents reduces competition for space on LSO cells, allowing glycinergic synapses to occupy a greater fraction of postsynaptic space.…”

Section: Bilateral Cochlear Ablationmentioning

confidence: 98%

Afferent regulation of glycine receptor distribution in the gerbil LSO

Koch

Sanes

1998

Microsc. Res. Tech.

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“…Briefly, both neurotransmitter substances, when applied exogenously, cause a rapid and reversible inhibition of spontaneous and tone-evoked activity in CN neurons, and this inhibition can be manipulated in each case by using the pharmacologically appropriate compounds, indicating that postsynaptic receptors sensitive to both GABA and glycine are present (Caspary et al, 1993(Caspary et al, , 1994. Elevated levels of glycine, GABA, and related enzymes have been found in all three divisions of the CN (Godfrey et al, 1978(Godfrey et al, , 1988, as have mechanisms for the high-affinity uptake and calcium-dependent release of both neurotransmitters (summarized in Potashner et al, 1993). None of these activities is diminished by cochlear ablation, indicating that they most likely originate from noncochlear sources (Potashner et al, 1985;Staatz-Benson and Potashner, 1988).…”

mentioning

confidence: 98%

GABA- and glycine-immunoreactive projections from the superior olivary complex to the cochlear nucleus in guinea pig

1997

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Retrograde transport of horseradish peroxidase was combined with immunocytochemistry to identify the origins of potential gamma-aminobutyric acid (GABA) -ergic and glycinergic inputs to different subdivisions of the cochlear nucleus. Projection neurons in the inferior colliculus, superior olivary complex, and contralateral cochlear nucleus were examined, but only those from the superior olivary complex contained significant numbers of GABA- or glycine-immunoreactive neurons. The majority of these were in periolivary nuclei ipsilaterally, with a sizeable contribution from the contralateral ventral nucleus of the trapezoid body. Overall, 80% of olivary neurons projecting to the cochlear nucleus were immunoreactive for GABA, glycine, or both. Most glycine-immunoreactive projection neurons were located ipsilaterally, in the lateral and ventral nuclei of the trapezoid body and the dorsal periolivary nucleus. This suggests that glycine is the predominant neurotransmitter used by ipsilateral olivary projections. Most GABA-immunoreactive cells were located bilaterally in the ventral nuclei of the trapezoid body. The contralateral olivary projection was primarily GABA-immunoreactive and provided almost half the GABA-immunoreactive projections to the cochlear nucleus. This suggests that GABA is the predominant neurotransmitter used by contralateral olivary projections. The present results suggest that the superior olivary complex is the most important extrinsic source of inhibitory inputs to the cochlear nucleus. Individual periolivary nuclei differ in the strength and the transmitter content of their projections to the cochlear nucleus and may perform different roles in acoustic processing in the cochlear nucleus.

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Distribution of gamma-aminobutyric acid, glycine, glutamate and aspartate in the cochlear nucleus of the rat.

Cited by 108 publications

References 18 publications

Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil

Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil

Afferent regulation of glycine receptor distribution in the gerbil LSO

GABA- and glycine-immunoreactive projections from the superior olivary complex to the cochlear nucleus in guinea pig

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