Distribution of Gene Frequencies and Discrimination Probabilities for 22 Human Blood Genetic Systems in Four Racial Groups

Grunbaum, Benjamin W.; Selvin, Steve; Myhre, Byron A.; Pace, Nello

doi:10.1520/jfs12150j

Cited by 35 publications

(17 citation statements)

References 12 publications

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“…First, admixture estimates were performed on the Mexican sample reported by Grunbaun et al (1980), utilizing their ABO, Rh-HR, MN, Fy (a), haptoglobin, and hemoglobin data, and they obtained estimates of 0.574, 0.401, and 0.025 for Indian, White, and Black ancestry, respectively, which are very similar to the present study (Table 3). This sample included 73% from blood donors at the Instituto Mexican0 del Seguro Social, which caters to a very low SES, while the remainder were Mexican Americans from California.…”

Section: Discussionsupporting

confidence: 77%

Racial admixture in a Mestizo population from Mexico City

Lisker

Ramírez

González‐Villalpando

et al. 1995

American J Hum Biol

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Seven genetic systems were used to investigate the racial composition of a sample from a low-income Mexico City Mestizo group, finding estimates of 0.590, 0.348, and 0.062 of Indian, White, and Black ancestry, respectively. The results are similar to another Mexico City group studied previously and to several Mestizo populations from different parts of the country. The one thing in common in all these groups is low socioeconomic status. There is only one report suggesting that Mexico City Mestizos have around 70% White ancestry, and there is reason to believe the sample was taken from a high socioeconomic group. It is suggested that low socioeconomic Mexican Mestizo groups are characterized by a high Indian ancestry, above 50%. © 1995 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 77%

Racial admixture in a Mestizo population from Mexico City

Lisker

Ramírez

González‐Villalpando

et al. 1995

American J Hum Biol

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“…In this regard we would like to make two points: 1) Of the 26 reported studies giving Fy(a) gene frequencies for Mexican Amerindians of sample size above 50 (Lisker, 1981), 21 reported frequencies above 0.65, which incidentally agrees well with the figure of 0.682 given by Krieger et al (1965) and which we employed as one of the ancestral gene frequencies in the admixture estimation; and 2) the 0.333 frequency here reported is lower than that obtained in five East Coast localities with obvious black admixture, where Fy(a) ranged from 0.406 to 0.602 and the admixture estimates from 21.7% to 40.5% (Lisker et al, 1969). Although positive and negative controls frequently included in the Fy(a) determinations were consistently correct, a laboratory error cannot be completely excluded as it is known that the agglutination test used to identify this marker involves a degree of subjective judgment (Grunbaum et al, 1980). For all of the above reasons, it is perhaps better to consider the figure of 10.7% for black ancestry in the State of Puebla as tentative and await an independent estimate which will be obtained in 2 or 3 years, when all the urban groups investigated in our present line of work will be simultaneously studied for the Gm system by M. Schanfield from Atlanta.…”

Section: Brief Geographical and Historical Considerationsmentioning

confidence: 63%

Gene frequencies and admixture estimates in the state of Puebla, Mexico

Lisker

Pérez-Briceño

Granados

et al. 1988

American J Phys Anthropol

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Three hundred ninety-three individuals from the Universidad Autónoma de Puebla and its University Hospital were studied to determine the distribution of ABO, MN, Rh-Hr, Duffy, and Diego blood groups; red cell hemoglobin and glucose-6-phosphate dehydrogenase variants; and serum haptoglobins, albumins, and factor Bf types. With the results we estimated that the proportions of black, indian, and white genes are 10.7%, 56.3%, and 33.0%, respectively, in a trihybrid model. Reasons are given as to why the black ancestry may be artifically high, and it is pointed out that independent confirmation with other markers is needed before the figure can be accepted as a true value.

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“…Included in Table are reference European (Euro) populations obtained from Grunbaum et al . () and Hashmi et al . ().…”

Section: Resultsmentioning

confidence: 88%

“… Reference data for Europeans obtained from Grunbaum et al ., (ABO, Rhesus, MNS, Kell, Kidd and Duffy) and Hashmi et al ., (Dombrock). …”

Section: Resultsmentioning

confidence: 98%

Molecular approaches to transfusion medicine in Polynesians and Maori in New Zealand

Edinur

Dunn²,

Lea

et al. 2013

Int J Immunogenetics

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In recent years, with the application of genotyping technology, there has been a substantial increase in the number of reported blood group alleles. This survey was designed to evaluate new molecular blood group genotyping methods and compile reference blood group data sets for Polynesian and Maori subjects. Subsequent analyses of these results were used to calculate probability of random match, to trace Polynesian ancestry and migration patterns and to reveal past and present episodes of genetic admixture. Genomic DNA samples from Maori and Polynesian subjects were drawn from the Victoria University of Wellington DNA Bank and genotyped using combination of commercial PCR-SSP kits, hybridization SNP assay services or sequence-based typing. This survey also involves compilation of serological ABO and Rhesus blood group data from RakaiPaaka Iwi tribal members for comparison with those generated during our molecular blood group study. We observed perfect consistency between results obtained from all molecular methods for blood group genotyping. The A, O, DCcEe, DCCee, MNs, K-k+, Jk(a+b-), Jk(a+b+), Fy(a+b-), Fy(a+b+), Di(a+b-), Co(a+b-) and Do(a-b+) were predominant blood group phenotypes in both Polynesians and Maori. Overall, our survey data show only small differences in distributions of blood group phenotypes between Polynesian and Maori groups and their subgroups. These differences might be associated with selection, population history and gene flow from Europeans. In each case, we estimate that patients with certain blood groups have a very low probability of an exact phenotypic match, even if the patients were randomly transfused with blood from donors of their own ethnicity. The best way to avoid haemolytic transfusion reaction in such cases is to perform a pretransfusion cross-match and recruit increased numbers of donors with rare phenotype profiles. The conclusion of this study is that application of molecular method covering as many known variants as possible may help to improve the accuracy blood group genotyping and potentially conserve the routine requirements of transfusion centres.

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Distribution of Gene Frequencies and Discrimination Probabilities for 22 Human Blood Genetic Systems in Four Racial Groups

Cited by 35 publications

References 12 publications

Racial admixture in a Mestizo population from Mexico City

Racial admixture in a Mestizo population from Mexico City

Gene frequencies and admixture estimates in the state of Puebla, Mexico

Molecular approaches to transfusion medicine in Polynesians and Maori in New Zealand

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