Distribution of Geriatric Disease-Related Genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA)

Shimokata, Hiroshi; Yamada, Yoshiji; Nakagawa, Masanori; Okubo, Ryuichi; Saido, Takaomi C.; Funakoshi, Akihiro; Miyasaka, Kyoko; Ohta, Shigeo; Tsujimoto, Gozoh; Tanaka, Masashi; Ando, Fujiko; Niino, Naoakira

doi:10.2188/jea.10.1sup_46

Cited by 33 publications

(27 citation statements)

References 32 publications

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“…The observed frequency of Mt5178A did not significantly deviate from the values reported in other genetic epidemiological studies, 26 suggesting no genetic bias in the subjects in this study.…”

Section: Discussionsupporting

confidence: 52%

Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men

et al. 2010

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The objective of this study was to investigate whether the mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism modifies the effects of coffee consumption on serum lipid levels and the risk of dyslipidemia in middle-aged Japanese men. A total of 397 male subjects (age, 53.9±7.8 years; mean±s.d.) were selected from among individuals visiting the hospital for regular medical check-ups. After adjustment for age, body mass index, habitual alcohol consumption, habitual smoking and use of antihypertensive medication, among subjects who consumed o1 cup of coffee per day, the odds ratio (OR) for hyper-low-density lipoprotein (LDL) cholesterolemia (serum LDL cholesterol X140 mg per 100 ml) was significantly lower in those with Mt5178A than in those with Mt5178C (OR¼0.378, 95% confidence interval: 0.153-0.919). After adjustment, the association between the Mt5178A genotype and hyper-LDL cholesterolemia depended on coffee consumption (P for trend¼0.018). Coffee consumption was positively associated with serum LDL cholesterol levels only in subjects with Mt5178A. However, in subjects with Mt5178C, serum LDL cholesterol level or risk of hyper-LDL cholesterolemia did not seem to depend on coffee consumption. These results suggest that for men with Mt5178A, coffee consumption negates the genetic benefit of lower risk for hyper-LDL cholesterolemia.

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Section: Discussionsupporting

confidence: 52%

Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men

et al. 2010

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“…The observed frequency of the mt5178A do not significantly differ from values reported previously, 1,[9][10][11][12] thus suggesting that there is no genetic bias in the subjects of this study.…”

Section: Discussioncontrasting

confidence: 52%

Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population

et al. 2003

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It has been reported that the mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism, also called NADH dehydrogenase subunit 2-237 methionine/ leucine (ND2-237 Met/Leu) polymorphism, may be associated with longevity in Japanese individuals, and that the mt5178A genotype may have an antiatherogenic influence. To determine whether mt5178 A/C polymorphism influences blood pressure, we genotyped 412 healthy Japanese individuals and performed a crosssectional study investigating the relationship between genotype and blood pressure. In women with mt5178A, the mean diastolic blood pressure was higher than in those with mt5178C by 3.2 mmHg (P ¼ 0.040). In men, no statistically significant difference in systolic or diastolic blood pressure was observed between mt5178 A/C genotypes. However, a significant correlation between mt5178 A/C genotypes and the effects of habitual drinking on blood pressure was found. After adjustment for several factors, in men carrying mt5178C, both systolic and diastolic blood pressure were significantly higher in daily drinkers than in occasional (P ¼ 0.002 and 0.002, respectively) as well as nondrinkers (Po0.001 and 0.001, respectively), whereas in men carrying mt5178A, no significant differences in blood pressure were detected, irrespective of alcohol consumption. These results suggest that mt5178 A/C ( ¼ ND2-237 Met/Leu) polymorphism may influence both diastolic blood pressure in Japanese women and the blood-pressureincreasing effect of drinking in Japanese men.

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“…The frequencies of the 5178A genotype and the 10398A genotype were 41.2 and 30.3%, respectively, in the present subjects. The frequencies of those genotypes in previous Japanese studies were 42-47% [Kato et al, 2000;Shimokata et al, 2000;Kokaze et al, 2001;Matsunaga et al, 2001;Wang et al, 2001] and 22-34% [Tanaka et al, 1998Kato et al, 2001], respectively. Therefore, the distribution of the C5178A and A10398G in the present subjects may be mostly consistent with the subjects in the previous Japanese studies.…”

Section: Discussionmentioning

confidence: 78%

Mitochondrial DNA polymorphisms and extraversion

Kato

Umekage

Tochigi

et al. 2004

American J of Med Genetics Pt B

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Mitochondria is the major site of energy production in cells, therefore, mitochondrial abnormality may affect functions of organs including the brain, which constantly requires high levels of energy consumption. Previous studies have suggested a role of mitochondria and their DNA polymorphisms in neuro-psychiatric disorders, including Alzheimer's disease, Parkinson's disease, schizophrenia and bipolar mood disorder. Thus, we hypothesized that mitochondrial DNA polymorphisms might be related with the development of personality. The present study investigated a role of two mitochondrial DNA polymorphisms, the C5178A and A10398G, in personality traits evaluated using the NEO PI-R scores in 238 healthy Japanese volunteers. Subjects with the 5178A genotype showed significantly higher extraversion score than those with the 5178C genotype (P = 0.027), while no significant association was observed between the C5178A polymorphism and other scores. No significant association was found between the A10398G polymorphism and any scores. Regarding the 5178-10398 haplotype, the score of extraversion, not other scores, was significantly associated with the A-G haplotype (P = 0.042). Although further studies are recommended for the confirmation, the result may suggest a role of the mitochondrial DNA polymorphism in the personality trait.

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Distribution of Geriatric Disease-Related Genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA)

Cited by 33 publications

References 32 publications

Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men

Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men

Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population

Mitochondrial DNA polymorphisms and extraversion

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