Distribution of Group A Rotavirus Genotypes Circulating in Gwangju, Korea

Abstract

To determine the distribution of rotavirus strain genotypes in Gwangju, Korea, we performed reverse-transcription polymerase chain reaction and nucleotide sequencing analysis using the 115 rotavirus EIA positive stool specimens collected from December 2006 through April 2007. The most predominant genotype was confirmed as G1P[8] (53.9%), followed by G3P[8] (29.6%), G4P[6] (8.7%), G2P[4] (4.3%) and G9P [8] (1.7%). A special attention is drawn to the unusual findings of the genotypes G11P[25] and G12P [9] during this study period. In order to investigate the phylogenetic relationships among the same or different genotypes, the nucleotide sequences of rotavirus circulating in Korea and the foreign countries were analyzed using MegAlign and Clustal X programme. The G11P [25] strain identified in this study showed the highest nucleic acid similarity with G11 /CUK1 /2006 /Korea (99.2%) and P[25] /Dhaka /2001 /BGD (98.7%). Meanwhile, the G12P[9] strain detected in this study shared 99.4~99.5% nucleotide homology with the reference strain G12P[9] /CP1030 /2004 /Japan. This incidence of new rotavirus genotypes in our area illustrates the large diversity of rotavirus strains found worldwide. Therefore, the epidemiological surveillance of rotavirus may need to be continued in a wide geographic area.

Distribution of rotavirus G and P genotypes approximately two years following the introduction of rotavirus vaccines in South Korea

“…Although G9 was first detected in South Korea in 2002, its prevalence in rural healthcare centers has increased from 7.4% to 39% [Kang et al, , ; Han et al, ] while remaining much lower (from 1% to 3%) in urban hospitals [Lee et al, ; Le et al, ; Kim et al, ; Jeong et al, ; Shim et al, ]. Even though current epidemiological data have been collected from nationwide or individual studies from South Korean provinces, the continuous study in Seoul is significant particularly because this city is the world's second largest metropolitan city.…”

Full genomic analysis of a human rotavirus G1P[8] strain isolated in South Korea

“…Rotavirus infections have been identified with common (G1P[8], G2P[4], G3P[8], G4P[6], and G9P[8]) and rare (G11P[25], G12P[6], and G12P[9]) genotypes in South Korea [Kim et al, 2009]. Among them, G1P[8] was the most prevalent strain.…”

“…Among them, G1P[8] was the most prevalent strain. According to recent studies in South Korea, The G1P[8] genotype prevalence rate was 33.1% and 53.9% [Park et al, 2007, Kim et al, 2009].…”

Outbreak associated with Rotavirus G11,P[25] in Korea in 2018

“…The infection of rotavirus G11, P[25] was first confirmed in a 21-year-old adolescent youth in Dhaka, Bangladesh [ 7 ], followed in Nepal [ 8 ] and India [ 9 10 ]. In Korea, there was a first case report in the Gwangju region during the acute diarrheal laboratory surveillance (EnterNet-Korea) [ 11 ], and thereafter another case report [ 5 ]. There was no report of other infections caused by pig-derived rotavirus other than infection by G11, P[4], which is known to be the same pig-derived rotavirus [ 1 ].…”

“…https://icjournal.org https://doi.org/10.3947/ic.2020.52.4.616 Outbreak with rotavirus G11,P[25] in Korea. laboratory surveillance (EnterNet-Korea) [11], and thereafter another case report [5]. There was no report of other infections caused by pig-derived rotavirus other than infection by G11, P [4], which is known to be the same pig-derived rotavirus [1].…”