Distribution of HLA-B alleles in Mexican Amerindian populations

Vargas‐Alarcón, Gilberto; Hernández-Pacheco, Guadalupe; Zúñiga, Joaquı́n; Rodrı́guez-Pérez, José Manuel; Pérez-Hernández, Nonanzit; Rangel, Carlos Félix Garrocho; Villarreal‐Garza, Cynthia; Martı́nez-Laso, Jorge; Granados, Julio; Arnaiz‐Villena, Antonio

doi:10.1007/s00251-002-0522-0

Cited by 24 publications

(5 citation statements)

References 24 publications

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“…These alleles have been described in various Amerindian (Native Americans) groups, such as the Nahuas [29]. In the Tarahumara indigenous population, HLA-A*24:02:01, B*40:02, DRB1*08:02:01, DQB*04:02 were described with a frequency greater than 10% [30], and these alleles have also been found in our study at a frequency > 5% in each region; interestingly, the HLA-B*40 has been reported in other Amerindian populations [31]. For HLA class II, DRB1*04:07 and DQB1*03:02 alleles have been reported mainly in the Amerindian population; in Mexico, it has been reported more frequently in the Mayos population to the northeast of the country [32], and these alleles have been found to be the most frequent for the three regions analyzed in our study.…”

Section: Discussionsupporting

confidence: 83%

HLA Allele and Haplotype Frequencies in Three Urban Mexican Populations: Genetic Diversity for the Approach of Genomic Medicine

et al. 2020

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Genetic variability defends us against pathogen-driven antigens; human leucocyte antigens (HLA) is the immunological system in charge of this work. The Mexican mestizo population arises mainly from the mixture of three founder populations; Amerindian, Spaniards, and a smaller proportion of the African population. We describe allele and haplotype frequencies of HLA class I (-A and -B) and class II (-DRB1 and -DQB1), which were analyzed by PCR-SSP in Mexican mestizo from three urban populations of Mexico: Chihuahua-Chihuahua City (n = 88), Mexico City-Tlalpan (n = 330), and Veracruz-Xalapa (n = 84). The variability of the allele HLA class I and class II among the three regions of Mexico are in four alleles: HLA-A*24:02 (36.39%), -B*35:01 (16.04%), -DRB1*04:07 (17.33%), and -DQB1*03:02 (31.47%), these alleles have been previously described in some indigenous populations. We identified 5 haplotypes with a frequency >1%: HLA-A*02:01-B*35:01-DRB1*08:02-DQB1*04:02, A*68:01-B*39:01-DRB1*08:02-DQB1*04:02, A*02:01-B*35:01-DRB1*04:07-DQB1*03:02, A*68:01-B*39:01-DRB1*04:07-DQB1*03:02, and A*01:01-B*08:01-DRB1*03:01-DQB1*02:01. Also, the haplotype A*02:01-B*35:01-DRB1*08:02-DQB1*04:02 was identified in Tlalpan and Xalapa regions. Haplotype A*01:01-B*08:01-DRB1*03:01-DQB1*02:01 was found only in Tlalpan and Chihuahua. In the Xalapa region, the most frequent haplotype was A*24:02-B*35:01-DRB1*04:07-DQB1*03:02. These alleles and haplotypes have been described in Amerindian populations. Our data are consistent with previous studies and contribute to the analysis of the variability in the Mexican population.

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Section: Discussionsupporting

confidence: 83%

HLA Allele and Haplotype Frequencies in Three Urban Mexican Populations: Genetic Diversity for the Approach of Genomic Medicine

et al. 2020

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“…genes, including the HLA markers, large molecular weight polypeptide (LMP) and angiotensin I-converting enzyme (ACE). [18][19][20] These studies showed than Mayos present important differences when compared to other Mexican Amerindian groups. We corroborate these differences using a different polymorphic marker not previously studied in these populations.…”

Section: P4501a1 Polymorphisms In Mexicans 191mentioning

confidence: 77%

β 1 Adrenergic Receptor Polymorphisms Arg389Gly and Ser49Gly in the Amerindian and Mestizo Populations of Mexico

Fragoso¹,

Rodrı́guez-Pérez²,

Pérez-Vielma³

et al. 2005

Human Biology

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Several polymorphisms in the CYP1A1 locus have been identified and their genotypes appear to exhibit population frequencies that depend on ethnicity. We studied two CYP1A1 polymorphic sites (position 4889 and 6235) in a group of 212 unrelated healthy individuals belonging to three different Mexican populations (106 Mexican Mestizos, 52 Teenek and 54 Mayos). Comparison among Mexican populations showed increased frequency of the *Ile allele (A on position 4889) in Mexican Mestizos when compared to Amerindians ( p < 0.05). The analysis of position 6235 showed increased frequencies of *m2 (C in this position) allele in Teenek when compared to Mestizos and Mayos ( p < 0.05) and of *m2/*m2 genotype when compared to Mestizos ( p < 0.05). Amerindian populations (from Mexico and South America) presented the lowest frequencies of *Ile (position 4889) and *m1 (position 6235) alleles, however these frequencies vary according to the ethnic group studied. Mexican Amerindian groups together with other South Amerindian populations showed the highest frequencies for *Val at position 4889 and the *m2 allele at position 6235. The present study corroborates the high frequencies of *Val and *m2 alleles in the Amerindian populations and detects some differences between Mexican populations that correlate with linguistic differences. Our data could be helpful in understanding the distribution of these polymorphisms and in clarifying their roles as genetic and evolution markers in Amerindian populations.

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“…However, it is important to note that in Sonora, the HLA-B*14 ,- B*27 ,- B*07 and- B*44 alleles are more frequent, which suggests a European genetic component [ 28 , 29 , 30 ]. For individuals from Mexico City, HLA-B*35 ,- B*39 and- B*40 are more frequent alleles and correspond to Amerindian populations [ 30 , 31 , 32 , 33 , 34 , 35 ] ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Prevalent HLA Class II Alleles in Mexico City Appear to Confer Resistance to the Development of Amebic Liver Abscess

et al. 2015

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Amebiasis is an endemic disease and a public health problem throughout Mexico, although the incidence rates of amebic liver abscess (ALA) vary among the geographic regions of the country. Notably, incidence rates are high in the northwestern states (especially Sonora with a rate of 12.57/100,000 inhabitants) compared with the central region (Mexico City with a rate of 0.69/100,000 inhabitants). These data may be related to host genetic factors that are partially responsible for resistance or susceptibility. Therefore, we studied the association of the HLA-DRB1 and HLA-DQB1 alleles with resistance or susceptibility to ALA in two Mexican populations, one each from Mexico City and Sonora. Ninety ALA patients were clinically diagnosed by serology and sonography. Genomic DNA was extracted from peripheral blood mononuclear cells. To establish the genetic identity of both populations, 15 short tandem repeats (STRs) were analyzed with multiplexed PCR, and the allelic frequencies of HLA were studied by PCR-SSO using LUMINEX technology. The allele frequencies obtained were compared to an ethnically matched healthy control group (146 individuals). We observed that both affected populations differed genetically from the control group. We also found interesting trends in the population from Mexico City. HLA-DQB1*02 allele frequencies were higher in ALA patients compared to the control group (0.127 vs 0.047; p= 0.01; pc= NS; OR= 2.9, 95% CI= 1.09-8.3). The less frequent alleles in ALA patients were HLA-DRB1*08 (0.118 vs 0.238 in controls; p= 0.01; pc= NS; OR= 0.42, 95% CI= 0.19-0.87) and HLA-DQB1*04 (0.109 vs 0.214; p= 0.02; pc= NS; OR= 0.40, 95% CI= 0.20-0.94). The haplotype HLA-DRB1*08/-DQB1*04 also demonstrated a protective trend against the development of this disease (0.081 vs. 0.178; p=0.02; pc=NS; OR= 0.40, 95% CI= 0.16-0.93). These trends suggest that the prevalent alleles in the population of Mexico City may be associated with protection against the development of ALA.

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Distribution of HLA-B alleles in Mexican Amerindian populations

Cited by 24 publications

References 24 publications

HLA Allele and Haplotype Frequencies in Three Urban Mexican Populations: Genetic Diversity for the Approach of Genomic Medicine

HLA Allele and Haplotype Frequencies in Three Urban Mexican Populations: Genetic Diversity for the Approach of Genomic Medicine

β 1 Adrenergic Receptor Polymorphisms Arg389Gly and Ser49Gly in the Amerindian and Mestizo Populations of Mexico

Prevalent HLA Class II Alleles in Mexico City Appear to Confer Resistance to the Development of Amebic Liver Abscess

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