Distribution of HOMA-IR in Brazilian subjects with different body mass indexes

Ghiringhello, Maria Teresa; Vieira, José Gilberto H.; Tachibana, Teresinha T.; Ferrer, Claudia; Maciel, Rui M. B.; Amioka, Patricia H.C; Hauache, Omar M.; Oliveira, Cláudia H.M.C.; Khawali, Cristina; Reis, André

doi:10.1590/s0004-27302006000300025

Cited by 26 publications

(22 citation statements)

References 5 publications

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“…Obesity is consistently associated with a set of metabolic diseases, including hypertension, atherosclerosis, dyslipidaemia, and type 2 DM, which commonly occur with MS 1,2,14,27,28. Furthermore, MS is characterized by hyperinsulinaemia and different IR intensities, which explains the relationship between various abnormalities and obesity 2,27.…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance and associated factors: a cross-sectional study of bank employees

Salaroli

Cattafesta

Molina

et al. 2017

Clinics

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OBJECTIVE:Insulin resistance is characterized by the failure of target cells to respond to normal levels of circulating insulin, and this condition is related to cardiovascular disease. This study sought to evaluate the prevalence of insulin resistance and its association with markers of metabolic abnormalities and metabolic syndrome in bank employees.METHODS:A cross-sectional study was performed on 498 working men and women aged ≥20 years old. The Homeostasis Model Assessment (HOMA-IR) was used to determine the presence of insulin resistance based on cut-off values of ≤2.71 for normal insulin levels and >2.71 for insulin resistance, as established for the adult Brazilian population.RESULTS:It was observed that the 52 (10.4%) overweight individuals with insulin resistance were 4.97 times (95%CI 1.31-18.83) more likely to have high HOMA-IR values than the normal-weight participants; among those who were obese, the likelihood increased to 17.87 (95%CI 4.36-73.21). Individuals with large waist circumferences were 3.27 times (95%CI 1.03-10.38) more likely to develop insulin resistance than those who were within normal parameters. The HOMA-IR values differed between subjects with and without metabolic syndrome, with values of 2.83±2.5 and 1.10±0.81 (p=0.001), respectively. The levels of insulin, ultrasensitive C-reactive protein and uric acid were also associated with insulin resistance.CONCLUSION:The prevalence of insulin resistance among bank employees is high, and insulin resistance is associated with and serves as a marker of metabolic syndrome. Cardiovascular disease and metabolic syndrome-associated metabolic abnormalities were observed, and insulin resistance may be a risk factor in this group of professionals.

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Section: Discussionmentioning

confidence: 99%

Insulin resistance and associated factors: a cross-sectional study of bank employees

Salaroli

Cattafesta

Molina

et al. 2017

Clinics

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“…Furthermore, the HOMA-IR mean values for DM1 did not differ from those of the DM2 group (Table 1), and did not show correlation with BChE activities in the DM1 group using logistic regression analyses. The HOMA-IR has been positively correlated to BMI (39).…”

Section: Butyrylcholinesterase and Diabetes Mellitusmentioning

confidence: 94%

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Cwiertnia

Alcântara

Réa

et al. 2010

Arq Bras Endocrinol Metab

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Objective: To investigate the relationship between butyrylcholinesterase (BChE) activities (total and band specific) and diabetes mellitus. Subjects and methods: BChE activities (BChEA, AC 4/5 , AC OF and RC 5 ) were analyzed in 101 type 1 (DM1) and in 145 type 2 (DM2) diabetic patients, in relation to phenotype, weight and incidence of metabolic syndrome (MS) in these patients. The C 4/5 and C 5 complex were separated from other molecular forms (C OF ) using an acid agar gel. Results: The BChE activity (BChEA) and the absolute activities of C 4/5 (AC 4/5 ) and C OF (AC OF ) showed a high positive correlation coefficient to weight in the CHE2 C5-group, while the relative activity of C 5 complex (RC 5 ) showed a negative correlation to weight. Conclusions: The present study suggests that the positive correlation of the BChE activities to diabetes mellitus and to insulin resistance may depend on the CHE2 locus variability. High values of BChE activities were associated with insulin resistance only in CHE2 C5-diabetic patients, while in CHE2 C5+ diabetic patients, the presence of C 5 complex, especially in a relatively high proportion, leads to less fat storage and better protection against metabolic syndrome. Arq Bras Endocrinol Metab. 2010;54(1):60-7 Keywords BCHE and CHE2 loci; C 4/5 and C 5 complexes; obesity, insulin resistance; metabolic syndrome; serum cholinesterase RESUMO Objetivo: Investigar a associação entre as atividades (total e banda específica) da butirilcolinesterase (BChE) e diabetes melito. Sujeitos e métodos: As atividades da BChE (BChEA, AC 4/5 , AC OF e RC 5 ) foram analisadas em 101 pacientes diabéticos do tipo 1 (DM1) e 145 do tipo 2 (DM2) em relação aos fenótipos, ao peso e à incidência da síndrome metabólica. Os complexos C 4/5 e C 5 foram separados das outras formas moleculares (C OF ), usando gel de ágar ácido. Resultados: A atividade da BChE (BChEA) e as atividades absolutas de C 4/5 (AC 4/5 ) e de C OF (AC OF ) mostraram altos coeficientes de correlações positivos com peso no grupo de CHE2 C5-, enquanto a atividade relativa do complexo C 5 (RC 5 ) mostrou correlação negativa com o peso. Conclusões: O presente estudo sugere que as correlações positivas das atividades da BChE com diabetes melito e com a resistência à insulina podem depender da variabilidade do loco CHE2. Altos valores nas atividades da BChE estão associados com a resistência à insulina somente nos pacientes diabéticos CHE2 C5-, enquanto nos pacientes diabéticos CHE2 C5+ a presença do complexo C 5 , especialmente em alta proporção relativa, leva a um menor estoque de gordura e à maior proteção contra a síndrome metabólica. Arq Bras Endocrinol Metab. 2010;54(1):60-7 DescritoresLocos BCHE e CHE2; complexos C 4/5 e C 5 ; obesidade, resistência à insulina; síndrome metabólica; colinesterase do soro

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“…Laboratory evaluation included lipid profile (total cholesterol, triglycerides, lowdensity lipoprotein, and high-density lipoprotein), FFAs, glucose, insulin, high-sensitivity C-reactive protein (CRP), and liver enzyme markers (alanine aminotransferase, aspartate aminotransferase, and gamma glutamyl transferase). The index Homeostasis Model Assessment-Insulin Resistance [HOMA1-IR) = fasting insulin (mU/L) 9 fasting glucose (mmol/L)/22.5] was calculated and classified according to body mass index (BMI) [24,25]. Blood glucose and lipid profiles were assessed using the enzymatic colorimetric method and the kinetic test for liver enzymes, and high-sensitivity CRP was analyzed using the immunoturbidimetric test; all these parameters were determined with the use of Bioclin Kits (Quibasa Basic Chemical Ltda, Belo Horizonte, Brazil) equipped with a BS-200 Chemistry Analyzer (Mindray Medical International, Shenzhen, China).…”

Section: Safety Assessmentmentioning

confidence: 99%

Noninvasive Body Contouring: Biological and Aesthetic Effects of Low-Frequency, Low-Intensity Ultrasound Device

et al. 2014

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Distribution of HOMA-IR in Brazilian subjects with different body mass indexes

Cited by 26 publications

References 5 publications

Insulin resistance and associated factors: a cross-sectional study of bank employees

Insulin resistance and associated factors: a cross-sectional study of bank employees

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Noninvasive Body Contouring: Biological and Aesthetic Effects of Low-Frequency, Low-Intensity Ultrasound Device

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