Distribution of injected fat-soluble vitamins in plasma and tissues of nursery pigs

Jang, Young Dal; Rotering, Mikayla J.; Isensee, Paige K.; Rinholen, Kirsten A.; Boston-Denton, Carli J.; Kelley, Paige G.; Stuart, R. L.

doi:10.5713/ajas.19.0987

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…The different responses of plasma vitamin A may have resulted from species differences, and the vitamin's form and dose may have potential effects on vitamin absorption. In addition, Jang et al reported that the plasma retinol value after feeding is associated with the relative growth rate and physiological status [19,20].…”

Section: Plasma Kinetic Behavior Of Different Forms Of Vitamin Amentioning

confidence: 99%

Effects of Vitamin Forms and Levels on Vitamin Bioavailability and Growth Performance in Piglets

et al. 2020

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The objective of this study was to quantify the relative bioavailability of microencapsulated vitamins A and E in nursery pigs and compare the effects of vitamin forms and vitamin levels on the plasma vitamin content and growth performance of weaned piglets. In experiment (Exp.) 1, 12 nursery pigs (fitted with jugular catheters) were supplied at 0 h with non-microencapsulated or microencapsulated vitamin A and E. Blood samples were collected at 1, 3, 6, 9, 12, 16, 18, 21, 24, 27, 30, 36, 48, and 72 h after feeding to compare the bioavailability of oral vitamins A and E. In Exp. 2, a total of 216 crossbred weaned piglets were assigned to six treatments. This experiment was a 2 × 3 factorial arrangement, with two factors for vitamin forms (non-microencapsulated and microencapsulated) and three factors for vitamin levels (the National Research Council level of vitamins, 75% commercial recommendations of vitamins (CRV) level, and a 100% CVR level). In Exp. 1, the relative bioavailability of microencapsulated vitamin E was significantly greater than that of non-microencapsulated vitamin E. In Exp. 2, the pigs fed diets containing 75% or 100% CRV levels of vitamins increased their growth performance and plasma vitamin concentrations compared to the control group. In conclusion, microencapsulation can improve the bioavailability of vitamins, and supplementation with high levels of vitamins was able to improve the growth performance of the piglets.

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Section: Plasma Kinetic Behavior Of Different Forms Of Vitamin Amentioning

confidence: 99%

Effects of Vitamin Forms and Levels on Vitamin Bioavailability and Growth Performance in Piglets

et al. 2020

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“…This may be explained by saying that these sampling time points in the previous study were not ideal for plasma retinol kinetics. Raila et al studied pharmacokinetic behavior of vitamin A in dogs [21]; they observed that the peak plasma concentration was observed at 8 h after a single oral 3000 IU/kg vitamin A, and then plasma vitamin A was decreased until reaching 72 h. Jang et al elucidated that the retinol concentration in blood was associated with physiological status and performance of pig [22]. The present study was designed to determine the relative bioavailability of microencapsulated supplement compared to normal form of supplement.…”

Section: Discussionmentioning

confidence: 93%

Determination and Evaluation of Bioavailability of Vitamins from Different Multivitamin Supplements Using a Pig Model

Yang

Wang

et al. 2021

Agriculture

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This study was performed to evaluate the plasma vitamin kinetic behavior following oral vitamin supplement administration in pigs, and to determine the bioavailability of vitamins. A total of 36 pigs (fitted with jugular catheters) with an average body weight of 25 ± 2.24 kg were divided into three treatment groups: (1) placebo, (2) non-microencapsulated multivitamins supplement, or (3) lipid matrix microencapsulated multivitamins supplement. The blood samples were obtained starting pre-meal until 72 h post-meal for plasma vitamin analysis. Pharmacokinetic parameters were modeled with a non-compartmental method. The AUC (Area under the curve) from the time of dosing to the time of the last observation, Cmax (Maximum observed concentration), and MRT (Mean residence time) of α-tocopherol from oral non-microencapsulated supplement were significantly lower than oral microencapsulated supplement (p < 0.01). The average relative bioavailability of vitamin A (VA) and vitamin E (VE) from microencapsulated supplement was greater than that from non-microencapsulated supplement, but relative bioavailability of vitamin K3 (VK3) and water-soluble vitamins from microencapsulated supplement was lower than non-microencapsulated supplement. The AUC and Cmax of menadione, thiamine, and riboflavin from microencapsulated supplement were significantly lower than these parameters from oral non-microencapsulated supplement. Lipid matrix microencapsulation was able to delay absorption and improved the bioavailability of VE, whereas there were limited effects of microencapsulation on vitamin D (VD), VK3, and water-soluble vitamins.

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“…Dependent upon the nutrient in question, a blood sample can sometimes determine nutrient deficiency or toxicity without having to euthanize animals for tissue sample collection. 2 Across many published references, serum or plasma samples have been analyzed to determine the vitamin A concentrations in pigs [3][4][5][6] without a consistent sampling protocol. However, serum and plasma are uniquely different biologically.…”

Section: Résumé -Influence De La Manipulation Pré-analytique D'échant...mentioning

confidence: 99%

Influence of biological sample pre-analytical manipulation for fat-soluble vitamin analysis

Elefson¹,

Greiner²

2023

JSHAP

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Objective: Determine how sample handling affects nutrient analysis of fat-soluble vitamins and minerals. Materials and methods: In experiment 1, blood was collected in either plasma or serum blood tubes and exposed to 4 hours of light or wrapped in aluminum foil to protect from light. In experiment 2, blood was collected at hours 0, 1, 2, 3, 4, 6, and 12 after the consumption of feed. In experiment 3, vitamins and minerals were assessed in varying degrees of hemolyzed blood samples. Experiment 4 evaluated liver samples exposed to various temperatures for up to 12 hours. In experiment 5, serum and liver samples were processed the day of, 1 day after, or 2 days after collection and subsequent placement into coolers with icepacks. Results: There was a significant difference (P < .05) for the interaction of tube type and light exposure for vitamin D (25-hydroxyvitamin D3) and a tendency (P < .10) for a tube type and light exposure interaction for vitamin A (retinol). Experiment 2 found serum vitamin concentrations changed post feed consumption both linearly and quadratically. Alpha-tocopherol peaked at 4 hours post meal consumption, whereas retinol peaked at 6 hours. In experiment 3, the degree of hemolysis affected (P < .05) nutrient concentration. Experiment 4 and 5 showed no differences (P > .05) in degradation of retinol and alpha-tocopherol. Implication: As many pre-analytical factors can affect laboratory results, care must be taken when collecting, handling, and storing samples for diagnostic analysis of vitamins and minerals.

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Distribution of injected fat-soluble vitamins in plasma and tissues of nursery pigs

Cited by 4 publications

References 14 publications

Effects of Vitamin Forms and Levels on Vitamin Bioavailability and Growth Performance in Piglets

Effects of Vitamin Forms and Levels on Vitamin Bioavailability and Growth Performance in Piglets

Determination and Evaluation of Bioavailability of Vitamins from Different Multivitamin Supplements Using a Pig Model

Influence of biological sample pre-analytical manipulation for fat-soluble vitamin analysis

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