Distribution of left ventricular trabeculation across age and gender in 140 healthy Caucasian subjects on MR imaging

Bentatou, Zakarya; Finas, Mathieu; Habert, Paul; Kober, Frank; Guye, Maxime; Bricq, Stéphanie; Lalande, Alain; Frandon, Julien; Dacher, Jean‐Nicolas; Dubourg, B.; Habib, Gilbert; Caudron, Jérôme; Normant, Sébastien; Rapacchi, Stanislas; Bernard, Monique; Jacquier, Alexis

doi:10.1016/j.diii.2018.08.014

Cited by 12 publications

(15 citation statements)

References 23 publications

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“…Both our patients and controls had similar non-compacted LV masses compared to healthy subjects in an earlier study [ 27 ]. but higher compared to two other studies [ 10 , 11 ]. The probable explanation for this difference is that our semi-automated method included more inter-trabecular space to non-compacted mass, as CMR does not differentiate between thin intertrabecular recesses from trabecular mass, and small inter-trabecular space is generally hard to quantify with cardiac imaging [ 21 , 28 ].…”

Section: Discussioncontrasting

confidence: 62%

“…Assessment of the global trabecular LV mass has shown good reproducibility in previous studies [10][11][12]. Both our patients and controls had similar non-compacted LV masses compared to healthy subjects in an earlier study [27].…”

Section: Plos Onesupporting

confidence: 68%

“…Non-compacted and compacted LV masses were measured by a single observer (J.K.) using a similar semi-automatic method as previously presented [10,11]. Measurements were independently repeated in twenty random subjects by another researcher (P.P.)…”

Section: Cmr Analysismentioning

confidence: 99%

“…Also, we were not able to define a cut-off value for non-compacted LV mass predisposing for cryptogenic stroke, as the assessment of global trabecular mass is method-dependent and we excluded the most basal LV slices for the consistency of measurements. Furthermore, we did not assess local non-compacted to compacted LV wall thickness ratio, frequently used to define isolated LVNC in CMR [32], but the global non-compacted LV mass which has shown high reproducibility in earlier studies [10][11][12].…”

Section: Plos Onementioning

confidence: 99%

“…Left ventricular (LV) non-compaction (LVNC) has been suggested as a rare cause of embolic stroke due to sluggish blood flow in deep intertrabecular recesses [8,9]. CMR imaging has shown good reproducibility to estimate the global non-compacted LV mass [10][11][12]. In this pilot case-control study, we studied whether non-compacted LV mass, the ratio of non-compacted to compacted LV mass, and the percentage of non-compacted LV volume evaluated with CMR are associated with cryptogenic ischemic stroke in the young.…”

Section: Introductionmentioning

confidence: 99%

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Left ventricular non-compaction as a potential source for cryptogenic ischemic stroke in the young: A case-control study

Pöyhönen

Kuusisto

Järvinen³

et al. 2020

PLoS ONE

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Background Up to 50% of ischemic strokes in the young after thorough diagnostic work-up remain cryptogenic or associated with low-risk sources of cardioembolism such as patent foramen ovale (PFO). We studied with cardiac magnetic resonance (CMR) imaging, whether left ventricular (LV) non-compaction-a possible source for embolic stroke due to sluggish blood flow in deep intertrabecular recesses-is associated with cryptogenic strokes in the young. Methods Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO; NCT01934725) is an international prospective multicenter case-control study of young adults (aged 18-49 years) presenting with an imagingpositive first-ever ischemic stroke of undetermined etiology. In this pilot substudy, 30 cases and 30 age-and sex-matched stroke-free controls were examined with CMR. Transcranial Doppler (TCD) bubble test was performed to evaluate the presence and magnitude of rightto-left shunt (RLS). Results There were no significant differences in LV volumes, masses or systolic function between cases and controls; none of the participants had non-compaction cardiomyopathy. Semiautomated assessment of LV non-compaction was highly reproducible. Non-compacted LV mass (median 14.0 [interquartile range 12.6-16.0] g/m 2 vs. 12.7 [10.4-16.6] g/m 2 , p = 0.045), the ratio of non-compacted to compacted LV mass (mean 25.6 ± 4.2% vs. 22.8 ± 6.0%, p = 0.015) and the percentage of non-compacted LV volume (mean 17.6 ± 2.9% vs. 15.7 ± 3.8%, p = 0.004) were higher in cases compared to controls. In a multivariate

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Section: Discussioncontrasting

confidence: 62%

Section: Plos Onesupporting

confidence: 68%

Section: Cmr Analysismentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Left ventricular non-compaction as a potential source for cryptogenic ischemic stroke in the young: A case-control study

Pöyhönen

Kuusisto

Järvinen³

et al. 2020

PLoS ONE

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Differentiation between Fabry disease and hypertrophic cardiomyopathy with cardiac T1 mapping

Deborde

Dubourg

Béjar

et al. 2020

Diagnostic and Interventional Imaging

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Quantification of right ventricular extracellular volume in pulmonary hypertension using cardiac magnetic resonance imaging

Habert

Capron

Hubert

et al. 2020

Diagnostic and Interventional Imaging

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The goal of that study was to assess the correlation of biventricular diffuse myocardial fibrosis in pulmonary hypertension (PH) as assessed by late gadolinium enhancement, extracellular volume (ECV) quantification with serum markers of collagen turnover and conventional prognostic markers from strain echocardiography. Methods: Twelve patients with PH underwent the same day: Transthoracic echocardiography: including measurement of right ventricular (RV) fractional shortening (RVfs), tricuspid annular plane systolic excursion (TAPSE), maximal tricuspid annular velocity, RV global and segmental deformation. Right heart catheterization measuring pulmonary arterial pressures in mmHg and cardiac output in l/min. 1.5T cardiac MRI measuring: right ventricular volumes and ejection fraction, native, and 15min post contrast T1 mapping using modified look-locker inversion-recovery (MOLLI) sequence. Serum quantification of two biomarkers of collagen turnover and hematocrit. Results: Global RV ECV, reflecting the quantity of myocardial fibrosis, was 34%±4.2 for our entire population. A significant correlation was found between RV ECV and: RVfs (r=0.6, p=0.026) S'wave velocity (r=0.7, p=0.009), TAPSE (r=0.6, p=0.040) and RV systolic ejection fraction on the CMR (r=0.6, p=0.04). There was no correlation between the ECV values in the lateral wall of the RV and in the septum (r= 0.4, p=0.206). A significant correlation between septal ECV and 2D septal strain (r=0.7, p=0.013) was found. Lastly, only a tendency was observed between the PIIINP values and RV ECV in a subgroup of 7 patients. 3 Conclusion: ECV quantification in PH appears to correlate with known echocardiographic prognostic markers and more specifically with the markers which assess RV systolic function. These results suggest that RV myocardial fibrosis measured with ECV could become a new prognostic parameter in PH.

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Distribution of left ventricular trabeculation across age and gender in 140 healthy Caucasian subjects on MR imaging

Cited by 12 publications

References 23 publications

Left ventricular non-compaction as a potential source for cryptogenic ischemic stroke in the young: A case-control study

Left ventricular non-compaction as a potential source for cryptogenic ischemic stroke in the young: A case-control study

Differentiation between Fabry disease and hypertrophic cardiomyopathy with cardiac T1 mapping

Quantification of right ventricular extracellular volume in pulmonary hypertension using cardiac magnetic resonance imaging

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