Distribution of lipofuscin as related to aging in the canine and porcine brain

Topographical localization of lipofuscin pigment in the brain of the aged fat-tailed dwarf lemur(Cheirogaleus Medius) and grey lesser mouse lemur(Microcebus Murinus): Comparison to iron localization

“…The most reliable and widespread cytological change correlated with neuronal aging is the formation of fluorescent age pigment or lipofuscin, which con-tains peroxidised lipids, proteins, and transition metals [Strehler, 1964;Whiteford & Getty, 1966;Sohal & Wolfe, 1986;Gutteridge, 1987;Kitani et al, 1995;Terman & Brunk, 1998]. Lipofuscin belongs to the lysosomal system and is a result of incomplete degradation of heterophagocytosed and/or autophagocytosed material [De Duve & Wattiaux, 1966].…”

The Senescent Sequences of Normal Processes

“…The constant changes in concentration of normally occurring substances by constant velocities or constant accelerations may lead to all the disturbances of senescence. The changes described here in the appearance of various substances late in life (9–15) undoubtedly have their origin in the very beginning of life. If there are any changes in the processes or in the kinetics of the synthesis of substances within the aging cell, they are not self‐evident nor have they been described to date.…”

Changes with age in the eye of the dog and hog from birth to senility

“…Parry 1954 Skold and Getty, 1961;Getty and Skold, 1962;Skold, Getty, and Ramsey, 1966;Getty, 1965;Getty, 1966), the gastric mucosa of the pig (Archer, 1963), the canine thyroid (Haensly, Jermier, and Getty, 1964), the canine adrenal Getty, 1965, 1968), the brain of the dog and pig (Whiteford and Getty, 1966), the spinal cord and dorsal root ganglia of the dog and hog (Few and Getty, 1967), and cardiac muscle of the dog Getty, 1968a, 1968b).…”