Distribution of lymphadenopathy in patients with Kikuchi disease

Positron emission tomography/computed tomography hypermetabolism of Kikuchi–Fujimoto disease mimicking malignant lymphoma: a case report and literature review

“…Extracervical lymphadenopathy in the abdomen, pelvis, inguinal region, axillae, and mediastinum is not uncommon and is associated with bilateral involvement of the cervical lymph nodes. 24 In the present case, the PET/CT images showed the patient's whole-body lymph node condition, thus providing valuable information on extracervical lymphadenopathy. Tsujikawa et al 7 reported the usefulness of PET/CT for distinguishing KFD and malignant lymphoma.…”

“…Chen et al. 24 reported that unilateral cervical lymphadenopathy was the most frequent form of lymph node involvement in patients with KFD. Extracervical lymphadenopathy in the abdomen, pelvis, inguinal region, axillae, and mediastinum is not uncommon and is associated with bilateral involvement of the cervical lymph nodes.…”

“…Xu et al 23 compared a case of KFD in a young Chinese woman with relevant cases in the literature and proposed a diagnostic flow chart of KFD to facilitate diagnosis and treatment and thus avoid misdiagnosis and mistreatment. Chen et al 24 reported that unilateral cervical lymphadenopathy was the most frequent form of lymph node involvement in patients with KFD. Extracervical lymphadenopathy in the abdomen, pelvis, inguinal region, axillae, and mediastinum is not uncommon and is associated with bilateral involvement of the cervical lymph nodes.…”

Kikuchi-Fujimoto Disease Involving Retroperitoneal Lymph Nodes: An Uncommon Presentation

“…Extra-cervical nodal presentation is not uncommon, the abdomen being the most common extra-cervical site in one study with an incidence of abdominal cases as high as 20% of KFD cases. 10 However, retroperitoneal involvement is rare, with only seven cases explicitly described as retroperitoneal since 1983 (Table 1). One study from Israel reported a uniquely different distribution of lymph node involvement, 11 with cervical involvement in only 44% of 19 cases, generalized lymphadenopathy in 26%, and retroperitoneal involvement in 21%; nevertheless, retroperitoneal cases worldwide are rarely reported.…”

“…Despite the increased availability of CT scans, these more recent studies still found cervical involvement to be the most common presentation, without an increase in cases of retroperitoneal involvement. 10,11,13 Although painful lymphadenopathy and fever constitute the most common presentation, other symptoms include weight loss, nausea, night sweats, upper respiratory symptoms, headache, and weakness. These symptoms likely reflect the acute inflammatory state.…”