Distribution of Lysosome-Associated Membrane Proteins-1 and -2, and Cathepsin D in Eosinophilic Granular Bodies: Possible Relationship to Cyst Development in Pilocytic Astrocytomas

Tung, Jai-Nien; Tsao, Tang‐Yi; Tai, Ching Tai; Yeh, Kun‐Tu; Cheng, Yong; Ming, Jiang

doi:10.1177/147323001003800417

Cited by 11 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, highly malignant non-Hodgkin's lymphoma and malignant cells of Hodgkin's disease displayed very strong CSE1L positivity, with staining of up to 80% of atypical cells [ 6 ]. CSE1L was recently shown to be expressed in brain pilocytic astrocytomas [ 47 ]. The expression of CSE1L was also reported to be higher in the primary and metastatic human colorectal carcinoma compared to the normal colon mucosa ( p < 0.0001) [ 48 ].…”

Section: Introductionmentioning

confidence: 99%

Cellular apoptosis susceptibility (CSE1L/CAS) protein in cancer metastasis and chemotherapeutic drug-induced apoptosis

Tai

Hsu

Shen

et al. 2010

J Exp Clin Cancer Res

View full text Add to dashboard Cite

The cellular apoptosis susceptibility (CSE1L/CAS) protein is highly expressed in cancer, and its expression is positively correlated with high cancer stage, high cancer grade, and worse outcomes of patients. CSE1L (or CAS) regulates chemotherapeutic drug-induced cancer cell apoptosis and may play important roles in mediating the cytotoxicities of chemotherapeutic drugs against cancer cells in cancer chemotherapy. CSE1L was originally regarded as a proliferation-associated protein and was thought to regulate the proliferation of cancer cells in cancer progression. However, the results of experimental studies showed that enhanced CSE1L expression is unable to increase proliferation of cancer cells and CSE1L regulates invasion and metastasis but not proliferation of cancer cells. Recent studies revealed that CSE1L is a secretory protein, and there is a higher prevalence of secretory CSE1L in the sera of patients with metastatic cancer. Therefore, CSE1L may be a useful serological marker for screening, diagnosis and prognosis, assessment of therapeutic responses, and monitoring for recurrence of cancer. In this paper, we review the expression of CSE1L in cancer and discuss why CSE1L regulates the invasion and metastasis rather than the proliferation of cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Cellular apoptosis susceptibility (CSE1L/CAS) protein in cancer metastasis and chemotherapeutic drug-induced apoptosis

Tai

Hsu

Shen

et al. 2010

J Exp Clin Cancer Res

View full text Add to dashboard Cite

show abstract

“…LAMP‐1 was shown to be upregulated in glioblastoma cell lines induced to undergo apoptosis . Both proteins are overexpressed in apoptotic astrocytoma cells thus believed to maintain their structural integrity in pilocystic astrocytomas .…”

mentioning

confidence: 99%

LAMP‐1 gene is overexpressed in high grade glioma

Sarafian

Koev²,

Mehterov

et al. 2018

APMIS

View full text Add to dashboard Cite

High-grade gliomas (HGG) are the most frequent brain tumors in adults. Glioblastoma multiforme (GBM) is their most aggressive form resistant to therapy. It was shown that inhibition of autophagy reduced GBM development and autophagy interfering agents are regarded as a new strategy to fight glioma cells. The lysosome-associated membrane proteins (LAMPs) display differential expression particularly in cancer. There are few data on their expression and especially on their molecular profile. The aim of the present study is to investigate the expression of LAMP-1 and LAMP-2 genes and proteins in HGG. Newly diagnosed patients with HGG and healthy controls were examined by immunohistochemistry and qPCR for both protein and mRNA levels of LAMP-1 and LAMP-2. The transcriptional activity of LAMP-1 in HGG was significantly higher compared to normal brain and to LAMP-2. The two glycoproteins were detected in the cytosol of tumor cells with varying intensity, LAMP-1 showing again enhanced expression. In conclusion, novel data on LAMP-1 overexpression in HGG are presented suggesting involvement of this gene and protein in cell adhesion and tumor progression. These findings might help the elucidation of the complex biological role of the multifunctional LAMPs proteins and to predict novel therapeutic targets in lysosomes.

show abstract

“…20 CSE1L was also found to be expressed in pilocytic astrocytomas. 21 The results of these pathological studies show that CSE1L is highly expressed in cancer and its expression is positively correlated with advanced cancer stage and grade. Therefore, CSE1L may play an important role in the regulation of cancer progression and may serve as a diagnostic marker for cancer.…”

Section: The Expression Of Cse1l In Cancermentioning

confidence: 98%