Distribution of mammalian facilitative glucose transporter messenger rna in bovine tissues

Zhao, Feng‐Qi; Glimm, David R.; Kennelly, J. J.

doi:10.1016/0020-711x(88)90322-9

Cited by 84 publications

(77 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As in other species, GLUT4 mRNA was detected in the heart, muscles and adipose tissue but not in non insulin-responsive tissues from cattle using either human [100] or bovine cDNA probes [3,49]. Unlike human organs, the liver and kidney of lactating cows express a high GLUT5 mRNA level [100], the physiological role of this transporter still being a matter of conjoncture [70].…”

Section: Immunological Studiesmentioning

confidence: 74%

“…Unlike human organs, the liver and kidney of lactating cows express a high GLUT5 mRNA level [100], the physiological role of this transporter still being a matter of conjoncture [70]. It is thought that GLUT5 participates in the uptake of glucose from the lumen of the small intestine and in the reabsorption of glucose in the kidney.…”

Section: Immunological Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Facilitative glucose transporters in livestock species

Hocquette

Abé

2000

Reprod. Nutr. Dev.

View full text Add to dashboard Cite

-The study of facilitative glucose transporters (GLUT) requires carefully done immunological experiments and sensitive molecular biology approaches to identify the various mechanisms which control GLUT expression at the RNA and protein levels. The cloning of species-specific GLUT cDNAs showed that GLUT4 and GLUT1 diverge less among species than other GLUT isoforms. The key role of GLUT in glucose homeostasis has been demonstrated in livestock species. In vitro studies have suggested specific roles of GLUT1 and GLUT3 in avian cells. In vivo studies have demonstrated a regulation of GLUTs (especially of GLUT4) by nutritional and hormonal factors in pigs and cattle, in lactating cows and goats and throughout the foetal life in the placenta and tissues of lambs and calves. All these results suggest that any changes in GLUT expression and activity (such as GLUT4 in muscles) could modify nutrient partitioning and tissue metabolism, and hence, the qualities of animal products (milk, meat).glucose transporter / pig / ruminant / poultry Résumé -Les transporteurs du glucose à diffusion facilitée chez les animaux de ferme. L'étude des transporteurs du glucose à diffusion facilitée (GLUT) nécessite des techniques en immunologie ou en biologie moléculaire précises et sensibles pour étudier la régulation de leur expression au niveau ARNm ou protéique. Le clonage d'ADNc des différents GLUT a montré que GLUT4 et GLUT1 divergent moins entre espèces que les autres isoformes de GLUT. Le rôle important des GLUT dans le contrôle de l'homéostasie du glucose a été démontré chez les animaux de ferme. Des études in vitro ont suggéré un rôle spécifique de GLUT1 et de GLUT3 dans les cellules aviaires. Des études in vivo ont mis en évidence une régulation des GLUT (notamment GLUT4) par des facteurs nutritionnels ou hormonaux chez le porc et le bovin, chez la vache ou la chèvre en lactation, et tout au long de la vie foetale dans le placenta et les tissus de l'agneau ou du veau. L'ensemble de ces résultats suggère que tout changement dans l'expression et l'activité des GLUT (tel que de GLUT4 dans les muscles) peut modifier la répartition des nutriments et le métabolisme tissulaire, et affecter ainsi la qualité des produits animaux (lait, viande).transporteur du glucose / porc / ruminant / volaille Reprod. Nutr. Dev. 40 (2000) 517-533 517

show abstract

Section: Immunological Studiesmentioning

confidence: 74%

Section: Immunological Studiesmentioning

confidence: 99%

Facilitative glucose transporters in livestock species

Hocquette

Abé

2000

Reprod. Nutr. Dev.

View full text Add to dashboard Cite

show abstract

“…It is also the organ system expressing the greatest amount of GLUT5 in human (13,20,47,79,81), rat (24, 35-38, 45, 72, 75, 84, 108, 112, 113, 139, 140, 147), mouse (22,33,83,107), rabbit (109), chicken (60), and horse (104). In cattle, GLUT5 expression in the intestine is significantly lower than in skeletal muscle (159), probably because this species is a foregut fermenter, and it is possible that fructose-like cellulose and other carbohydrate products are fermented in the stomach and little sugar reaches the intestinal lumen.…”

Section: Physiology and Functionmentioning

confidence: 99%

Regulation of the fructose transporter GLUT5 in health and disease

Douard¹,

Ferraris²

2008

American Journal of Physiology-Endocrinology and Metabolism

400

366

View full text Add to dashboard Cite

Fructose is now such an important component of human diets that increasing attention is being focused on the fructose transporter GLUT5. In this review, we describe the regulation of GLUT5 not only in the intestine and testis, where it was first discovered, but also in the kidney, skeletal muscle, fat tissue, and brain where increasing numbers of cell types have been found to have GLUT5. GLUT5 expression levels and fructose uptake rates are also significantly affected by diabetes, hypertension, obesity, and inflammation and seem to be induced during carcinogenesis, particularly in the mammary glands. We end by highlighting research areas that should yield information needed to better understand the role of GLUT5 during normal development, metabolic disturbances, and cancer.

show abstract

“…Thus the extraction efficiency of glucose by the udder could depend mainly on the capacity for transmembrane transport and/or intracellular metabolism of glucose. However, in mammary epithelial cells of ruminants, Zhao et al [17] admitted that, under normal physiological conditions, the GLUT1 transporter protein which predominates in the bovine mammary gland [17][18][19], is probably never saturated. Thus regulation of glucose extraction by bovine mammary epithelial cells may occur at another level than transmembrane transport [20].…”

Section: The Mammary Utilisation Of Glucosementioning

confidence: 99%

Changes in mammary uptake and metabolic fate of glucose with once-daily milking and feed restriction in dairy cows

et al. 2006

View full text Add to dashboard Cite

-The aim of this review is to better understand the regulation of milk yield in response to once-daily milking and feed restriction. Glucose is the principal precursor for the synthesis of lactose (a major osmotic agent in milk), and participates in determining the milk volume produced. When applying these two breeding factors, reductions in milk yield are associated with a reduction in milk lactose yield and in the arterial flow of glucose, due to a decrease in the mammary blood flow. The ability of the udder to extract glucose is altered with once-daily milking but not necessarily with feed restriction. Lactose synthesis is down-regulated in response to once-daily milking and feed restriction but the percentage of the extracted glucose which is converted into lactose is differently affected in response to treatments. No marked change is observed with once daily milking whereas this would be increased with feed restriction and in contrast, depressed with fasting. milk yield / glucose / mammary gland / uptake / metabolic fate / ruminants

show abstract

Distribution of mammalian facilitative glucose transporter messenger rna in bovine tissues

Cited by 84 publications

References 23 publications

Facilitative glucose transporters in livestock species

Facilitative glucose transporters in livestock species

Regulation of the fructose transporter GLUT5 in health and disease

Changes in mammary uptake and metabolic fate of glucose with once-daily milking and feed restriction in dairy cows

Contact Info

Product

Resources

About