Distribution of mast cells in the feline ovary in various phases of the oestrous cycle

Abstract

This study is the first description of the distribution of mast cells in various phases of the oestrous cycle in the ovary of cat. Furthermore, this is the first description in species with an induced ovulation. The aim was to describe the distribution of mast cells and variability of their numbers in the feline ovaries in different phases of the oestrous cycle. The number of mast cells in medulla ovarii was affected by the estradiol and progesterone level in the blood serum because the lowest number was detected in anoestrus when the levels of hormones were basal. Nevertheless, both high and low numbers of mast cells were found in oestrus and dioestrus. To conclude, mast cells seem to be essential for the induction of spontaneous ovulation, but they do not play the same role for ovulation itself in cats with induced ovulation.

Changes in the mast cell distribution in the canine ovary and uterus throughout the oestrous cycle

“…A significantly higher number of MCs was found in the early follicular phase compared with anoestrus in the bitch, which agrees with previous reports in cats (Hamouzova, Cizek, Novotny, et al, ). Data gathered in the present study show that the cyclic changes in the number of MCs in the canine ovary follow a pattern similar to that reported in the feline ovary, despite the differences between the two species' reproductive physiology.…”

“…The effect of the oestrous cycle phase on the number of MCs in the ovary is known in cats (Hamouzova, Cizek, Novotny, Bartoskova, & Tichy, ), cows (Nakamura et al, ; Ozen et al, ), goats (Karaca, Arikan, Kalender, & Yoruk, ) and rodents (Batth & Parshad, ; Karaca et al, ). The highest number of MCs was reported in the follicular phase in most species (Hamouzova, Cizek, Novotny, et al, ; Karaca et al, ; Nakamura et al, ; Ozen et al, ). In rats, however, the highest number of MCs was found during the transitional E2/P4 stage (Batth & Parshad, ; Karaca et al, ).…”

Mast cells—Good guys with a bad image?

“…[139][140][141][142] While some studies suggest a constant number of ovarian MCs throughout the cycle, 143,143 other studies suggest an increased number or activity of ovarian MCs during ovulation. 144,145 It has been proposed for various mammals that the MCreleased mediator histamine is one of the main mediators during the ovulation process 142,143 by (i) stimulating the contractility of smooth muscle cells of the ovary, (ii) fostering the progesterone production, and (iii) having vasodilatory effects on the ovarian vasculature. 146 Also serotonin 147,148 and IL-8 149 secreted by MCs seems to play a role during ovulation by stimulating the progesterone production or follicle growth.…”

Serum Triiodothyronine, Thyroxine, and Thyroid Stimulating Hormone Concentrations of Domestic Female Cats at Different Reproductive Stages

“…According to that, cats were classified as in estrous when E2 levels were higher than 20 pg/ml. The queens having higher P4 levels than 1.5 ng/ml were classified as in diestrus and, E2 and P4 levels lower than 20 pg/ml and 1.5 ng/ml respectively were classified as in interestrus (Hamouzova et al, 2017;Kabakci et al, 2020). The range limits of assays for E2 and P4 were 5 -3000 pg/mL and 0.05 -60 ng/mL, respectively.…”