Distribution of mucosal pathology and an assessment of colonic phenotypic change in the pelvic ileal reservoir.

Shepherd, Neil A.; Healey, Chris; Warren, Bryan F.; Richman, P. I.; Thomson, William; Wilkinson, Steven

doi:10.1136/gut.34.1.101

Cited by 155 publications

(61 citation statements)

References 22 publications

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“…The reason suggested is a mucosal reaction to injury by an altered milieu [9]. Mucin histochemistry showing a change in the epithelial mucin to colorectal type of sulphomucin has been reported by various workers [1,10,11] and was a consistent finding in our study.…”

Section: Clinicalsupporting

confidence: 89%

Restorative Proctocolectomy with Ileo-anal Reservoir, a Histopathological, Histochemical, and Electron Microscopic Study

Chadha

Mukherjee

Subramanya

et al. 2003

Medical Journal Armed Forces India

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This study was conducted to investigate the nature of colonic metaplasia in ileo-anal pouches and incidence / frequency of pouchitis in the same. Biopsy specimens from 8 patients with functioning ileal pouches were studied using routine histology, mucin histochemistry and electron microscopy, over a 2 -year period. All 8 patients had villous abnormalities in the form of blunting of villi and sub total or partial villous atrophy. 6 patients had an increase in the goblet cell population and Paneth cell hyperplasia. These changes were supported by electron microscopic findings of a decrease in number and flattening of ileal type microvilli and their transformed morphologic resemblance to colonic type microvilli. All the ileal pouches also had acquired colorectal type sulphomucin, when sections stained with Alcian-blue and High Iron Diamine -Alcian blue, were studied. However, no case of pouchitis as defined in literature, was found in this study. MJAFI 2003; 59 : 306-309

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Section: Clinicalsupporting

confidence: 89%

Restorative Proctocolectomy with Ileo-anal Reservoir, a Histopathological, Histochemical, and Electron Microscopic Study

Chadha

Mukherjee

Subramanya

et al. 2003

Medical Journal Armed Forces India

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“…Within a year of the procedure there is a switch from a small intestinal to a colonic mucin pattern. The principal change is to the carbohydrate component as evidenced by increased sulphation and O-acetylation [55,56]. Pouchitis, which occurs mainly in subjects with ulcerative colitis, has been viewed as a return of the disease in a segment of ileum that has undergone an adaptive 'colonisation'.…”

Section: Ileo-anal Pouchmentioning

confidence: 99%

Altered mucin expression in the gastrointestinal tract: a review

Jass

Walsh

2001

J Cellular Molecular Medi

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Early studies of changes in mucin expression in disorders of the gastrointestinal tract focused on alterations in the carbohydrate chain. This review briefly considers the various mechanisms by which such alterations may come about: (a) normal variation, (b) sialic acid alterations, (c) defective assembly of carbohydrate side-chains, (d) changed expression of core proteins and (e) epithelial metaplasia. The availability of monoclonal antibodies to mucin core proteins adds a new dimension to mucin histochemistry. It is now possible to offer explanations for traditional mucin histochemical findings on the basis of lineage-specific patterns of mucin core protein expression. Changes in core protein expression are described in inflammatory, metaplastic and neoplastic disorders of the gastrointestinal tract. The possibility that mucin change could be important in the aetiology of some diseases such as ulcerative colitis and H. pylori gastritis is considered. It is more probable, however, that changes in mucin expression are secondary to reprogramming of cellular differentiation and altered cell turnover. As such they may serve as markers to explain pathogenesis and provide novel diagnostic and prognostic information.

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“…From etiological and pathogenetic perspectives, a variety of factors may contribute to the initiation, development, and progression of the disease. These factors include genetic predisposition, 20,21 dysbiosis, 1-4 altered mucosal immunity, [22][23][24][25][26][27][28] and colonic metaplasia due to fecal stasis, 29,30 A previous study demonstrated that a decreased intramucosal pH with mucosal acidosis characteristic of hypoperfusion was associated with an increased risk for the development of pouchitis. 15 The findings of the current study suggest that pouchitis with endoscopic asymmetric inflammation may be associated with ischemic factors.…”

Section: Discussionmentioning

confidence: 99%

Asymmetric endoscopic inflammation of the ileal pouch: A sign of ischemic pouchitis?

Shen¹,

Plesec²,

Remer³

et al. 2010

Inflammatory Bowel Diseases

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Distribution of mucosal pathology and an assessment of colonic phenotypic change in the pelvic ileal reservoir.

Cited by 155 publications

References 22 publications

Restorative Proctocolectomy with Ileo-anal Reservoir, a Histopathological, Histochemical, and Electron Microscopic Study

Restorative Proctocolectomy with Ileo-anal Reservoir, a Histopathological, Histochemical, and Electron Microscopic Study

Altered mucin expression in the gastrointestinal tract: a review

Asymmetric endoscopic inflammation of the ileal pouch: A sign of ischemic pouchitis?

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