Distribution of OL-protocadherin protein in correlation with specific neural compartments and local circuits in the postnatal mouse brain

Aoki, Eiko; Kimura, Rikuko; Suzuki, Shintaro; Hirano, Shinji

doi:10.1016/s0306-4522(02)00944-2

Cited by 54 publications

(59 citation statements)

References 38 publications

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“…PCDH10 protein is expressed in certain local circuits of functional systems such as the olfactory system, nigrostriatal projection, olivocerebellar projection and visual system. 25,26 These results are consistent with the finding that PCDH10-deficient mice have defects in axon pathfindings of striatal neurons and thalamocortical projections. 27 PCDH19 protein is also expressed in retinofugal projections.…”

Section: Spatial and Temporal Expression Of Non-clustered Pcdhs In Thsupporting

confidence: 89%

“…28 Studies on mRNA expressions have been carried out more systemically. Some non-clustered PCDHs show the region-specificity in the basal ganglia 25,29 with gradients (PCDH8, PCDH9, PCDH10, PCDH17 and PCDH19) and/or the matrix/striosome-based expression patterns (PCDH1, PCDH8, PCDH9, PCDH large exon encodes the entire extracellular portion as well as the transmembrane domain and a short cytoplasmic part, thus giving rise to a complete PCDH molecule. If additional exons for an extension of the cytoplasmic domain are absent, the corresponding PCDH would be a single-exon gene such as the b subfamily of the clustered PCDHs 18,19 and PCDH7b of nonclustered PCDHs ( Fig.…”

Section: Spatial and Temporal Expression Of Non-clustered Pcdhs In Thmentioning

confidence: 99%

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Non-clustered protocadherin

Kim¹,

Yasuda²,

Tanaka³

et al. 2011

Cell Adhesion & Migration

218

228

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Section: Spatial and Temporal Expression Of Non-clustered Pcdhs In Thsupporting

confidence: 89%

Section: Spatial and Temporal Expression Of Non-clustered Pcdhs In Thmentioning

confidence: 99%

Non-clustered protocadherin

Kim¹,

Yasuda²,

Tanaka³

et al. 2011

Cell Adhesion & Migration

218

228

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“…The cytoplasmic domain of the OL-pc isoform (Aoki et al, 2003) Millipore, rat monoclonal, clone 5G10, Cat. # MABT20, Lot # NRG1759424 ;Furutama et al, 2010), PLC␤4 (Marzban et al, 2007, EphA4 Mikoshiba, 2003), andPcdh10 (Hirano et al, 1999).…”

Section: Pcdh10mentioning

confidence: 99%

Clustered Fine Compartmentalization of the Mouse Embryonic Cerebellar Cortex and Its Rearrangement into the Postnatal Striped Configuration

et al. 2012

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Compartmentalization is essential for a brain area to be involved in different functions through topographic afferent and efferent connections that reflect this organization. The adult cerebellar cortex is compartmentalized into longitudinal stripes, in which Purkinje cells (PCs) have compartment-specific molecular expression profiles. How these compartments form during development is generally not understood. To investigate this process, we focused on the late developmental stages of the cerebellar compartmentalization that occur from embryonic day 17.5 (E17.5), when embryonic compartmentalization is evidently observed, to postnatal day 6 (P6), when adult-type compartmentalization begins to be established. The transformation between these compartmentalization patterns was analyzed by mapping expression patterns of several key molecular markers in serial cerebellar sections in the mouse. A complete set of 54 clustered PC subsets, which had different expression profiles of FoxP2, PLC␤4, EphA4, Pcdh10, and a reporter molecule of the 1NM13 transgenic mouse strain, were distinguished in three-dimensional space in the E17.5 cerebellum. Following individual PC subsets during development indicated that these subsets were rearranged from a clustered and multilayered configuration to a flattened, single-layered and striped configuration by means of transverse slide, longitudinal split, or transverse twist spatial transformations during development. The Purkinje cell-free spaces that exist between clusters at E17.5 become granule cell raphes that separate striped compartments at P6. The results indicate that the ϳ50 PC clusters of the embryonic cerebellum will ultimately become the longitudinal compartments of the adult cerebellum after undergoing various peri-and postnatal transformations that alter their relative spatial relationships.

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“…In 1-day and older embryos, it was also expressed in the diencephalon, the hindbrain, the otocyst epithelium, the eye muscles, and the fin buds. pcdh10 expression in the central nervous system (CNS) was described previously in mouse late embryos and neonates (Hirano et al, 1999;Aoki et al, 2003), although they used an isoform with a shorter cytoplasmic domain lacking the conserved motifs CM-1 and 2, in contrast to the present study in which the longer isoform was examined. Our preliminary investigations have indicated neither the presence nor absence of the shorter variant of Pcdh10 in zebrafish.…”

Section: Pcdh10 In Head and Central Nervous Systemmentioning

confidence: 99%

Zebrafish protocadherin 10 is involved in paraxial mesoderm development and somitogenesis

Murakami

Hijikata

Matsukawa

et al. 2005

Developmental Dynamics

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Here, we present the first report of the molecular cloning of zebrafish protocadherin 10 (Pcdh10, OLprotocadherin) and describe its functional analyses in the development of segmental plate. Epitope-tagged Pcdh10 expressed in embryos was localized on cell peripheries of adjacent cells. In situ hybridization showed that pcdh10 was expressed in the paraxial mesoderm (PAM) and developing somites, and in the pineal body, the diencephalon, and the vicinity of otocysts. Expression in PAM increased in the last few presumptive somites, reached the maximum level in the latest segmenting somites, and decreased thereafter during somite maturation. These expression patterns suggested that Pcdh10 is involved in development of PAM and somites. This was confirmed by morpholino knockdown and dominant-negative inhibition of Pcdh10 in embryos, which disturbed movements of PAM cells and somite segmentation. Comparative studies showed that pcdh10 expression lasted up to approximately three times longer in maturing somites than that of paraxial protocadherin (pcdh8). They also indicated that the adaxial cells expressed pcdh8 but not pcdh10. We propose that Pcdh10 is involved in the morphogenic movements of PAM cells and somite segmentation and that differential adhesion of Pcdh8 and Pcdh10 plays a role in the morphogenic machinery of somites and adaxial cells. Developmental Dynamics 235:506 -514, 2006.

show abstract

Distribution of OL-protocadherin protein in correlation with specific neural compartments and local circuits in the postnatal mouse brain

Cited by 54 publications

References 38 publications

Non-clustered protocadherin

Non-clustered protocadherin

Clustered Fine Compartmentalization of the Mouse Embryonic Cerebellar Cortex and Its Rearrangement into the Postnatal Striped Configuration

Zebrafish protocadherin 10 is involved in paraxial mesoderm development and somitogenesis

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