Distribution of pituitary adenylate cyclase activating polypeptide mRNA in the developing rat brain

Skoglösa, Ylva; Takei, Nobuyuki; Lindholm, Dan

doi:10.1016/s0169-328x(98)00294-0

Cited by 86 publications

(55 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PACAP-LI was absent from the retina in the zebrafi sh at day 13 of larval development, suggesting that PACAP may have a role in the control of cell differentiation and proliferation [ 36 , 37 ]. In the rat, PACAP mRNA was expressed in the GCL in the developing retina at E20 [ 38 ].…”

Section: Distribution Of Pacap In the Retinamentioning

confidence: 99%

Protective Effects of PACAP in the Retina

Atlasz

Vaczy

Werling

et al. 2016

Current Topics in Neurotoxicity

View full text Add to dashboard Cite

Pituitary adenylate cyclase activating polypeptide (PACAP) is a widespread neuropeptide that is well known for its general cytoprotective effects in different neuronal injuries, such as traumatic brain and spinal cord injury, models of neurodegenerative diseases, and cerebral ischemia. PACAP and its receptors also occur in the retina. In this review, we summarize the retinoprotective effects of PACAP. In vitro, PACAP is protective against glutamate, thapsigargin, anisomycin, oxidative stress, UV light, high glucose, infl ammation, and anoxia. Both the neural retina and the pigment epithelial cells can be protected by PACAP in various experimental paradigms. In vivo, the protective effects of intravitreal PACAP treatment have been shown in the following models in rats and mice: excitotoxic injury induced by glutamate, N -methyl-D -aspartate (NMDA) or kainate, ischemic injury induced by carotid artery ligation and high intraocular pressure, degeneration caused by UV-A light, optic nerve transection, and streptozotocin-induced diabetic retinopathy as well as retinopathy of prematurity. Molecular biological methods have revealed that PACAP activates anti-apoptotic, while inhibits pro-apoptotic signaling pathways, and it also stimulates an anti-infl ammatory environment in the retina. Altogether, PACAP is suggested to be a potential therapeutic retinoprotective agent in various retinal diseases.

show abstract

Section: Distribution Of Pacap In the Retinamentioning

confidence: 99%

Protective Effects of PACAP in the Retina

Atlasz

Vaczy

Werling

et al. 2016

Current Topics in Neurotoxicity

View full text Add to dashboard Cite

show abstract

“…One good candidate for a PKA activator is pituitary adenylate cyclase activating polypeptide (PACAP) (Sherwood et al, 2000). PACAP is made by Purkinje cells (Nielsen et al, 1998;Skoglosa et al, 1999) and its receptors are expressed by GCPs in the outer EGL (Basille et al, 1993). To date, most studies of PACAP in the cerebellum have indicated that it increases proliferation of GCPs and promotes survival in the presence of various death-inducing stimuli (Vaudry et al, 1999(Vaudry et al, ,2002Tabuchi et al, 2001).…”

Section: Granule Cell-cycle Exit and Differentiationmentioning

confidence: 99%

Analysis of Gene Expression in the Normal and Malignant Cerebellum

Wechsler‐Reya¹

2003

Recent Progress in Hormone Research

View full text Add to dashboard Cite

The developing nervous system consists of a small number of multipotent precursors that undergo extensive proliferation to generate the neurons and glia that make up the adult brain. Elucidating the mechanisms that control the growth and differentiation of these cells is important not only for understanding normal neural development but also for understanding the etiology of central nervous system tumors. A particularly striking example of this is in the cerebellum. Recent studies have suggested that the Sonic hedgehog-Patched signaling pathway plays a critical role in regulating the proliferation of cerebellar granule cell precursors and is also a major target of mutation in the cerebellar tumor medulloblastoma. In light of these observations, identification of additional genes that control cerebellar growth and differentiation is likely to provide important insight into the basis of cerebellar tumors. Similarly, analysis of gene expression in medulloblastoma will no doubt shed light on previously unknown signaling pathways that regulate normal cerebellar development. The advent of high-throughput gene expression analysis techniques -such as adapter-tagged competitive polymerase chain reaction (ATAC-PCR), serial analysis of gene expression (SAGE), and DNA microarrays -makes identification of such genes faster and easier than ever before. This review summarizes recent studies of gene expression in the cerebellum and discusses the value of such approaches for understanding development and tumorigenesis in this tissue.

show abstract

“…PACAP1 receptors (PAC 1 Rs), specific for PACAP, are expressed predominantly in the brain, whereas VPAC receptors, which bind both VIP and PACAP, are more common in the periphery (Hashimoto et al, 1993). PACAP ligand and the PAC 1 R are found in the CA1 region of the hippocampus (Shioda et al, 1998;Skoglosa et al, 1999;Zhou et al, 2000a,b). PACAP stimulates both PKA and protein kinase C (PKC)-dependent signaling pathways (Zhou et al, 2001), suggesting a potential role for PACAP in this region of the hippocampus.…”

Section: Introductionmentioning

confidence: 99%