Distribution of polyethylene wear particles and bone fragments in periprosthetic tissue around total hip joint replacements

Zolotarevova, E.; Entlicher, G.; Pavlová, Ewa; Šlouf, Miroslav; Pokorný, D; Veselý, F; Gallo, Jiří; Sosna, A

doi:10.1016/j.actbio.2010.04.010

Cited by 21 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of the studies on UHMWPE debris report material characterization of a large range of sizes (0.1 to 10 μm) [101,104,105,119–121] with irregular-shaped particles of higher aspect ratio [114]. Nano-sized (18.5–21.2 nm) UHMWPE wear debris were recently investigated in vivo for the first time by Lapcikova et al .…”

Section: Debris Characterizationmentioning

confidence: 99%

Wear Debris Characterization and Corresponding Biological Response: Artificial Hip and Knee Joints

et al. 2014

View full text Add to dashboard Cite

Wear debris, of deferent sizes, shapes and quantities, generated in artificial hip and knees is largely confined to the bone and joint interface. This debris interacts with periprosthetic tissue and may cause aseptic loosening. The purpose of this review is to summarize and collate findings of the recent demonstrations on debris characterization and their biological response that influences the occurrence in implant migration. A systematic review of peer-reviewed literature is performed, based on inclusion and exclusion criteria addressing mainly debris isolation, characterization, and biologic responses. Results show that debris characterization largely depends on their appropriate and accurate isolation protocol. The particles are found to be non-uniform in size and non-homogeneously distributed into the periprosthetic tissues. In addition, the sizes, shapes, and volumes of the particles are influenced by the types of joints, bearing geometry, material combination, and lubricant. Phagocytosis of wear debris is size dependent; high doses of submicron-sized particles induce significant level of secretion of bone resorbing factors. However, articles on wear debris from engineered surfaces (patterned and coated) are lacking. The findings suggest considering debris morphology as an important parameter to evaluate joint simulator and newly developed implant materials.

show abstract

Section: Debris Characterizationmentioning

confidence: 99%

Wear Debris Characterization and Corresponding Biological Response: Artificial Hip and Knee Joints

et al. 2014

View full text Add to dashboard Cite

show abstract

“…From the size distributions shown in Table 1, the UHMWPE debris from the spinal simulator was somewhat in agreement with that of other TJRs [9,[15][16][17][18][19][20][21]. However it is difficult to make direct comparisons as test, sample preparation and assessment methodologies and equipment vary between research groups [8].…”

Section: Discussionmentioning

confidence: 83%

“…Mobile bearings [9] Knee joint simulator Elongated, fibril like, and spherical 0.2-0.8 μm AFM, SEM Revision surgery of THRs [15] Periprosthetic tissues Cylindrical, slice and spherical 0.1-10 μm and N10 μm SEM, IR, EDX/EDS Mobile bearing [16] Hip joint simulator Round, flake, stick, and twig Frequently occurs within range of 1-30 μm, but overall size range is 0. filters and prepared for SEM and imaged in the same way as the in vitro implant samples outlined above.…”

Section: Typementioning

confidence: 98%

The evolution of polymer wear debris from total disc arthroplasty

2015

View full text Add to dashboard Cite

a b s t r a c tTotal disc arthroplasty is an alternative to spinal fusion, aimed at preserving flexibility; these devices typically involve a cobalt chrome molybdenum alloy socket articulating against an ultra-high molecular weight polyethylene (UHMWPE) ball. As with all artificial joints, wear debris is of particular concern due to its effect on both implant life and the in vivo biological reactions that can occur. In this paper, a profile of the UHMWPE wear debris generated from disc arthroplasty, tested on a spine simulator, is built with a combination of SEM image analysis tools. SEM images were analysed by computer vision, which allowed size and shape information to be extracted and images to be categorised by the shared topological features on individual wear particles. The computer visions techniques were based on a Scale Invariant Feature Transform (SIFT) to extract key point data from individual images and a Support Vector Decision Machine (SVM) to filter images based on a series of trained parameters. As certain wear particle morphology is predominantly produced by a particular wear regime, grouping wear particles by morphology and size made it possible to infer the relative rates of various wear regimes responsible for wear debris generation. By sampling synovial lubricant at intervals throughout the tribological test, the predominant wear regimes and particle sizes were tracked over the course of the implant life. Wear debris samples were taken at 12 intervals over a 5 million cycle test. The majority of debris was found to be 0.88 μm in equivalent circle diameter, with an aspect ratio (defined as the major over the minor diameter of the smallest possible encompassing ellipse of the debris) of 1.55. There was a decreasing trend in average particle size as the number of cycles increased. During the early stages of the test, adhesion and abrasion were dominant in forming particle morphologies, however after 2 million cycles; particles generated as a result of fatigue became the major particle morphology.

show abstract

“…Particles are non-homogenously distributed around an artificial joint coming in continuous contact with diverse cell groups and their receptors. 81,82 Even distant extra-articular distribution of prosthetic particles has been reported. 83 In addition, metallic ions (corrosion by-products) can be cytotoxic, carcinogenic, and genotoxic.…”

Section: Evidence For Contribution Of Innate Sensor Signaling Inmentioning

confidence: 99%

Innate Immunity Sensors Participating in Pathophysiology of Joint Diseases: A Brief Overview

Gallo

Raška

Konttinen

et al. 2014

J Long Term Eff Med Implants

View full text Add to dashboard Cite

The innate immune system consists of functionally specialized “modules” that are activated in response to a particular set of stimuli via sensors located on the surface or inside the tissue cells. These cells screen tissues for a wide range of exogenous and endogenous danger/damage-induced signals with the aim to reject or tolerate them and maintain tissue integrity. In this line of thinking, inflammation evolved as an adaptive tool for restoring tissue homeostasis. A number of diseases are mediated by a maladaptation of the innate immune response, perpetuating chronic inflammation and tissue damage. Here, we review recent evidence on the cross talk between innate immune sensors and development of rheumatoid arthritis, osteoarthritis, and aseptic loosening of total joint replacements. In relation to the latter topic, there is a growing body of evidence that aseptic loosening and periprosthetic osteolysis results from long-term maladaptation of periprosthetic tissues to the presence of by-products continuously released from an artificial joint.

show abstract

Distribution of polyethylene wear particles and bone fragments in periprosthetic tissue around total hip joint replacements

Cited by 21 publications

References 27 publications

Wear Debris Characterization and Corresponding Biological Response: Artificial Hip and Knee Joints

Wear Debris Characterization and Corresponding Biological Response: Artificial Hip and Knee Joints

The evolution of polymer wear debris from total disc arthroplasty

Innate Immunity Sensors Participating in Pathophysiology of Joint Diseases: A Brief Overview

Contact Info

Product

Resources

About