Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain

Quadros, Princy S.; Pfau, Jennifer L.; Wagner, Christine K.

doi:10.1002/cne.21427

Cited by 97 publications

(106 citation statements)

References 81 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…This cell type has the greatest potential for a critical role in steroid-mediated protection of neurons in the brain, since ablation of astrocytes in vivo results in a significant decrease in neuronal survival (Cui et al 2001). Indeed, astrocytes are well-described target cells for E and P expressing the corresponding nuclear steroid receptors (Jung Testas et al 1992, Santagati et al 1994, Beyer 1999, Quadros et al 2007. Confirming previously published data (Pawlak et al 2005), we observed transcripts for ERa, ERb, and PR in cortical astrocytes from both genders.…”

Section: Discussionsupporting

confidence: 88%

Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones

Arnold¹,

Araújo²,

Beyer³

2008

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

Astroglia and steroid hormones such as estrogen and progesterone regulate cell growth, function, and protection in the central nervous system (CNS). It appears that astrocytes and steroids act in concert to promote cell survival under pathological conditions. With respect to the role of mitochondrial fusion and fission in energy metabolism, apoptosis, and proliferation, astrocyte mitochondria resemble a perfect intracellular target for steroids to modulate these processes, thereby promoting cell vitality after damage. We have studied the effects of estrogen and progesterone on cell viability in comparison with mitochondrial fusion and fission gene transcription in primary cortical astrocytes from female and male mouse brains. Estrogen-and progesterone-treated female astrocytes demonstrated an increase in cell number and proliferation marker accompanied by an upregulation of fusion and fission gene transcription, which were apparently balancing pro-and anti-apoptotic processes. On the other hand, male astrocytes exhibited no change in cell number after estrogen treatment, but a decrease after progesterone administration. This could be the consequence of stimulated apoptosis in male astrocytes by both steroids, which was counterbalanced by an increased proliferation in the presence of estrogen, whereas it was strengthened in the presence of progesterone. Supportively, estrogen promoted and progesterone decreased the transcription of fusion and fission genes. We suggest that estrogen and progesterone affect mitochondrial fusion and fission gene transcription in cortical astrocytes in a gender-specific way, thereby influencing mitochondrial function differently in both genders. Thus, interaction of sex steroids with mitochondria may represent one possible cause for gender differences in cellular pathology in the CNS.

show abstract

Section: Discussionsupporting

confidence: 88%

Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones

Arnold¹,

Araújo²,

Beyer³

2008

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

show abstract

“…The medial preoptic nucleus, which contains the SDN-POA, also expresses nuclear hormone receptors, making these regions direct targets of hormone imprinting via ERα [25], ERβ [93], AR [97] and PR [123]. Figure 1 shows representative photomicrographs from two young adult male Sprague-Dawley rats at the SDN-POA level, which exemplify the relative density and expression of ERα and AR.…”

Section: Sexually Dimorphic Nucleus Of the Preoptic Area (Sdn-poa)mentioning

confidence: 99%

Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems

Gore¹

2008

Frontiers in Neuroendocrinology

231

122

View full text Add to dashboard Cite

The ability of a species to reproduce successfully requires the careful orchestration of developmental processes during critical time points, particularly the late embryonic and early postnatal periods. This article begins with a brief presentation of the evidence for how gonadal steroid hormones exert these imprinting effects upon the morphology of sexually differentiated hypothalamic brain regions, the mechanisms underlying these effects, and their implications in adulthood. Then, I review the evidence that aberrant exposure to hormonally-active substances such as exogenous endocrine-disrupting chemicals (EDCs), may result in improper hypothalamic programming, thereby decreasing reproductive success in adulthood. The field of endocrine disruption has shed new light on the discipline of basic reproductive neuroendocrinology through studies on how early life exposures to EDCs may alter gene expression via non-genomic, epigenetic mechanisms, including DNA methylation and histone acetylation. Importantly, these effects may be transmitted to future generations if the germline is affected via transgenerational, epigenetic actions. By understanding the mechanisms by which natural hormones and xenobiotics affect reproductive neuroendocrine systems, we will gain a better understanding of normal developmental processes, as well as to develop the potential ability to intervene when development is disrupted.

show abstract

“…Finally, another explanation could be that peripubertal ZK treatment has affected cognitive abilities. Rat studies have shown that PR is expressed transiently in the developing cortex and progesterone might thus play a role in cortical development (Quadros et al, 2007). Although a recent study (Willing and Wagner, 2014) using PRKO mice suggested some role for PR in maturation of cortical connectivity and sensorimotor integration, clearly more research is needed to elucidate the role of PR in cortical development.…”

mentioning

confidence: 99%

Potential contribution of progesterone receptors to the development of sexual behavior in male and female mice

Desroziers

Brock

Bakker

2017

Hormones and Behavior

View full text Add to dashboard Cite

We previously showed that estradiol can have both defeminizing and feminizing effects on the developing mouse brain. Pre-and early postnatal estradiol defeminized the ability to show lordosis in adulthood, whereas prepubertal estradiol feminized this ability. Furthermore, we found that estradiol upregulates progesterone receptors (PR) during development, inducing both a male-and female-typical pattern of PR expression in the mouse hypothalamus. In the present study, we took advantage of a newly developed PR antagonist (ZK 137316) to determine whether PR contributes to either male-or female-typical sexual differentiation. Thus groups of male and female C57Bl/6j mice were treated with ZK 137316 or oil as control: males were treated neonatally (P0-P10), during the critical period for male sexual differentiation, and females were treated prepubertally (P15-P25), during the critical period for female sexual differentiation. In adulthood, mice were tested for sexual behavior. In males, some minor effects of neonatal ZK treatment on sexual behavior were observed: latencies to the first mount, intromission and ejaculation were decreased in neonatally ZK treated males; however, this effect disappeared by the second mating test. By contrast, female mice treated with ZK during the prepubertal period showed significantly less lordosis than OIL-treated females. Mate preferences were not affected in either males or females treated with ZK during development. Taken together, these results suggest a role for PR and thus perhaps progesterone in the development of lordosis behavior in female mice. By contrast, no obvious role for PR can be discerned in the development of male sexual behavior.

show abstract

Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain

Cited by 97 publications

References 81 publications

Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones

Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones

Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems

Potential contribution of progesterone receptors to the development of sexual behavior in male and female mice

Contact Info

Product

Resources

About