Distribution of rotavirus genotypes in Japan from 2015 to 2018: Diversity in genotypes before and after introduction of rotavirus vaccines

Hoque, Sirajul; Khandoker, Nusrat; Thongprachum, Aksara; Khamrin, Pattara; Takanashi, Sayaka; Okitsu, Shoko; Nishimura, Shigeyuki; Kikuta, Hídeaki; Yamamoto, Akira; Sugita, Kumiko; Baba, Toru; Kobayashi, Mariko; Hayakawa, Satoshi; Mizuguchi, Masashi; Maneekarn, Niwat; Ushijima, Hiroshi

doi:10.1016/j.vaccine.2020.03.061

Cited by 27 publications

(38 citation statements)

References 35 publications

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“…Along these lines, other studies have reported significant differences between the VP8* P[8] genotype strains circulating in Belgium, where most belong to lineage III, as opposed to Rotarix (lineage I) and RotaTeq (lineage II) strains [ 51 ]. Similar results have been documented in countries such as India [ 98 ], Russia [ 99 ] and Japan [ 100 ].…”

Section: Rv Genotypes Included In the Vaccinessupporting

confidence: 87%

The Rotavirus Vaccine Landscape, an Update

et al. 2021

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Rotavirus is the leading cause of severe acute childhood gastroenteritis, responsible for more than 128,500 deaths per year, mainly in low-income countries. Although the mortality rate has dropped significantly since the introduction of the first vaccines around 2006, an estimated 83,158 deaths are still preventable. The two main vaccines currently deployed, Rotarix and RotaTeq, both live oral vaccines, have been shown to be less effective in developing countries. In addition, they have been associated with a slight risk of intussusception, and the need for cold chain maintenance limits the accessibility of these vaccines to certain areas, leaving 65% of children worldwide unvaccinated and therefore unprotected. Against this backdrop, here we review the main vaccines under development and the state of the art on potential alternatives.

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Section: Rv Genotypes Included In the Vaccinessupporting

confidence: 87%

The Rotavirus Vaccine Landscape, an Update

et al. 2021

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“…However, in countries using RotaTeq or the mixed vaccine including the United states, Korea, and Japan, different or no consistent dominance pattern with elevated G2P [4] detection was observed [3]. For instance, common genotypes of the pre-vaccination era like G1P [8] and G3P [8] was reduced after the introduction of RV vaccine, whereas unusual G2P [4], G9P [8], and G8P [8] strains emerged and reemerged in the post-vaccination period in Japan [28,29]. In the US, G3P [8] and G12P [8] dominated in 2009-11 and 2012-13, respectively [21].…”

Section: Discussionmentioning

confidence: 99%

The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] Strain

et al. 2021

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This study evaluated the long-term impact of rotavirus vaccination on prevalence, seasonality, and genotype distribution in Gwangju, Korea for 13 seasons. Rotavirus was identified using ELISA and then sequenced for G and P genotypes by Reverse Transcription Polymerase Chain Reactions for diarrhoeagenic patient specimens from local hospitals between January 2008 and August2020. Of 26,902 fecal samples, 2919 samples (10.9%) were ELISA positive. The prevalence declined from 16.3% in pre-vaccine era to 5.4% in post-vaccine era. In the pre-vaccine period, G1P[8] was the most common genotype, followed by G2P[4], G3P[8], and G9P[8], etc. In the transitional period, the proportion of G2P[4] became the dominant genotype and G1P[8] was still commonly identified. In contrast, the novel genotype G8P[8] was predominant in the post-vaccine period. Meanwhile, G2P[4] and G8P[8] were major genotypes in both Rotarix and RotaTeq groups. The substantial decline of G1P[8] prevalence, reemergence of G1P[8], G3P[8], and G2P[4] rotavirus strains, and surge of the rare G8P[8] after vaccine introduction were interesting points to note. The continuous surveillance on the genotypes of RV will be needed to understand rotavirus epidemiology and their evolutionary patterns, as caution is required when interpreting temporal changes in RV genotype dynamic.

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“…However, this RVA prevalence was higher than those in developed countries where the RVA vaccine has been introduced into their childhood national routine immunization programs (12). In Japan, the detection rates of RVA in 2017 and 2018 were 17.9% and 13%, respectively (13).…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Acute Rotavirus Diarrhea Among Hospitalized Children Under Five Years of Age in Hefei, China, During 2015 - 2018

Yuan

Lum

Zhao

et al. 2020

Jundishapur J Microbiol

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Background: Rotavirus infection is still the leading cause of acute viral gastroenteritis in children under five years of age worldwide. It is also a serious public health concern in China. Objectives: This study aimed to obtain information about rotavirus diarrhea among hospitalized children in Hefei City, Anhui Province, China, in recent years. Methods: We conducted a retrospective study over four years (2015 - 2018) examining hospital admission records of rotavirus infections at the First Affiliated Hospital of Anhui Medical University in Hefei City of Anhui Province, China. Results: A total of 1,095 cases with acute viral gastroenteritis requiring hospital admission from January 2015 to December 2018 were analyzed. Among them, 276 cases were positive for rotavirus A infection, accounting for 25.21% of the total number of children suffering from acute diarrhea. The detection rate of rotavirus A was the highest in children aged 1 - 2 years. The peak month for rotavirus infection during 2015 - 2018 was December and January. The hospitalized children with rotavirus infection showed dehydration, electrolyte disorder, liver function abnormality, and myocardial enzyme abnormality. Conclusions: Rotavirus is still the first pathogen of acute viral diarrhea in children in Hefei, especially children < 2 years of age, which highlights the need for widespread rotavirus immunization in young children.

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Distribution of rotavirus genotypes in Japan from 2015 to 2018: Diversity in genotypes before and after introduction of rotavirus vaccines

Cited by 27 publications

References 35 publications

The Rotavirus Vaccine Landscape, an Update

The Rotavirus Vaccine Landscape, an Update

The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] Strain

Epidemiology of Acute Rotavirus Diarrhea Among Hospitalized Children Under Five Years of Age in Hefei, China, During 2015 - 2018

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