Distribution of selenium between fractions in erythrocytes, plasma, hair, and fingernails of Chinese women living in selenium-deficient, -adequate, and -excessive areas of China

Xia, Yiming; Ha, P.; Hill, Kristina E.; Butler, Jane; Whanger, P. D.

doi:10.1002/1520-670x(2000)13:4<333::aid-jtra2>3.0.co;2-p

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…Selenium is universally present as an antioxidant in nature and in organisms. The selenium median concentration in our population study was 22.0 µg/L, which was considerably lower than that in populations in the south (102.27 µg/L) [ 11 ] or central (65.2 µg/L) [ 12 ] China population, German adults (61.38 µg/L) [ 36 ], and Latin American adults (91.51 µg/L) [ 37 ], but was similar to those in populations in areas of selenium deficiency in China (Xichang: 27 µg/L) [ 38 ]. Our present study identified a negative association between plasma selenium and the risk of diminished kidney function in accordance with previous studies conducted on areas of selenium deficiency or adequacy, but not in areas of selenium excess [ 39 , 40 , 41 ].…”

Section: Discussionsupporting

confidence: 49%

Combined Exposure to Multiple Metals and Kidney Function in a Midlife and Elderly Population in China: A Prospective Cohort Study

Wang

Zhang

Liu

et al. 2023

Toxics

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[Background] Metal exposure is suspected to be correlated to kidney function. However, the combined effects of co-exposing to multiple metals, especially both toxic and protective metals, have not been completely evaluated. [Method] A prospective cohort study was conducted with the “135” cohort for the evaluation of how plasma metal levels are correlated to kidney function in a midlife and elderly community in southern China. An amount of 1368 subjects without kidney disease at baseline were enrolled in the final analysis. By using linear regression and logistic regression models, the correlation of individual metal values with renal function parameters was assessed. Measuring of the multiple metal exposure level was performed by principal component analysis (PCA). [Results] Diminished renal function, as evaluated based on fast kidney function decline, or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2, was positively associated with the plasma concentrations of chromium and potassium, but it was negatively associated with selenium and iron (p < 0.05). In multiple-metal analyses, linear and logistic regression models showed that the iron and chromium exposure pattern had a protective effect on renal function, whereas the sodium and potassium exposure pattern and the cadmium and lead exposure pattern increased the risk for fast kidney function decline, and eGFR < 60 mL/min/1.73 m2. [Conclusions] Certain metals, including chromium, potassium, selenium, and iron, were correlated with kidney function in a midlife and elderly community in China. In addition, the potential combined influences of co-exposing to multiple metals were observed.

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Section: Discussionsupporting

confidence: 49%

Combined Exposure to Multiple Metals and Kidney Function in a Midlife and Elderly Population in China: A Prospective Cohort Study

Wang

Zhang

Liu

et al. 2023

Toxics

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“…This phenomenon is graphically depicted in Fig. 1, which is a summary of several reports of Se speciation in plasma of human subjects (25)(26)(27)(28)(29)(30)(31)(32)(33)(34). The figure shows that as the concentration of total Se in plasma increases, the percentage of that total accounted for by selenoproteins is reduced, and the fraction of Se present in other forms, such as SeMet in plasma proteins, correspondingly rises.…”

mentioning

confidence: 77%

Selenium and Prostate Cancer Prevention: What Next—If Anything?

Christensen

2014

Cancer Prevention Research

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Chemopreventive effects of the essential trace element selenium against prostate cancer have been shown in preclinical models and human observational studies, but results from clinical trials have been disappointing. It appears that there is a threshold selenium (Se) status below which improvement will decrease prostate cancer risk, but above which supplemental Se may be deleterious. Different forms of selenium have different effects, and genetic and other factors modify selenium's chemopreventive potential.

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“…In plasma Se is incorporated (as selenocysteine) also into selenoprotein P, and bound (as selenomethionine) to albumin (Deagen et al, 1993;Xia et al, 2000). The liver is the main organ in the metabolism and homeostasis of selenium in the human body (Buljevac et al, 1996;Whanger, 1998), because these selenoproteins are predominantly synthesized and secreted by the liver (Deagen et al, 1993;Behne & Kyriakopoulos, 2001).…”

mentioning

confidence: 99%

Selenium, glutathione and glutathione peroxidases in blood of patients with chronic liver diseases.

Czuczejko¹,

Zachara²,

Staubach-Topczewska³

et al. 2003

Acta Biochim Pol

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Disturbances in the antioxidant system could play a role in pathogenesis of chronic liver disease. The aim of our study was to evaluate the levels/activities of antioxidants in blood of patients with chronic liver disease. We estimated selenium and glutathione concentrations and glutathione peroxidase activities in blood of 59 patients with chronic hepatitis B or C virus infection (group 1) and 64 patients with alcoholic, autoimmune or cryptogenic chronic liver disease (group 2). The results were compared with 50 healthy controls.Whole blood and plasma selenium and red cell glutathione concentrations were significantly lower in the patients compared with the controls. Red cell glutathione peroxidase activity was slightly reduced in both subgroups of group 1 and in group 2 with normal alanine aminotransferase values. Plasma glutathione peroxidase activity was slightly but significantly higher in patients with elevated aminotransferase values.The findings suggest that disturbances in antioxidant parameters in blood of patients with chronic liver disease may be the cause of the peroxidative damage of cells.

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Distribution of selenium between fractions in erythrocytes, plasma, hair, and fingernails of Chinese women living in selenium-deficient, -adequate, and -excessive areas of China

Cited by 11 publications

References 28 publications

Combined Exposure to Multiple Metals and Kidney Function in a Midlife and Elderly Population in China: A Prospective Cohort Study

Combined Exposure to Multiple Metals and Kidney Function in a Midlife and Elderly Population in China: A Prospective Cohort Study

Selenium and Prostate Cancer Prevention: What Next—If Anything?

Selenium, glutathione and glutathione peroxidases in blood of patients with chronic liver diseases.

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