Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing study

Gerfen, Charles R.; Young, W. Scott

doi:10.1016/0006-8993(88)91217-6

Cited by 613 publications

(347 citation statements)

References 33 publications

Supporting

Mentioning

319

Contrasting

Unclassified

Order By: Relevance

“…This is supported by a recent preliminary report using pair recordings with high intracellular chloride to enhance unitary IPSCs (Koos et al, 2002), as well as by other indirect studies (Rebec and Curtis, 1988). It was shown that neurons immunoreactive for SP and ENK received GABAergic synapses modulated by either D 1 or D 2 receptor agonists, suggesting that pathways containing one or both receptor types (Gerfen et al, 1990;Gerfen, 2000) communicate with one another (Aronin et al, 1986;Bolam and Izzo, 1988;Gerfen and Young, 1988;Yung et al, 1996).…”

Section: Ipscs From Axon Collateralsmentioning

confidence: 56%

“…The globus pallidus (GP) was first lesioned with ibotenic acid to destroy intrinsic pallidal cells. Related questions were whether modulation produced by D 1 receptor agonists is different from, or even opposed to, that produced by D 2 receptor agonists (Floran et al, 1990(Floran et al, , 1997Radnikow and Misgeld, 1998;Cooper and Stanford, 2001) and whether spiny neurons from the direct and the indirect pathways (Gerfen and Young, 1988;Albin et al, 1989) are synaptically interconnected (Aronin et al, 1986;Bolam and Izzo, 1988;Yung et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum

et al. 2003

View full text Add to dashboard Cite

Dopamine is a critical modulator of striatal function; its absence produces Parkinson's disease. Most cellular actions of dopamine are still unknown. This work describes the presynaptic actions of dopaminergic receptor agonists on GABAergic transmission between neostriatal projection neurons. Axon collaterals interconnect projection neurons, the main axons of which project to other basal ganglia nuclei. Most if not all of these projecting axons pass through the globus pallidus. Thus, we lesioned the intrinsic neurons of the globus pallidus and stimulated neostriatal efferent axons antidromically with a bipolar electrode located in this nucleus. This maneuver revealed a bicuculline-sensitive synaptic current while recording in spiny cells. D 1 receptor agonists facilitated whereas D 2 receptor agonists depressed this synaptic current. In contrast, a bicuculline-sensitive synaptic current evoked by field stimulation inside the neostriatum was not consistently modulated, in agreement with previous studies. The data are discussed in light of the most recent experimental and modeling results. The conclusion was that inhibition of spiny cells by axon collaterals of other spiny cells is quantitatively important; however, to be functionally important, this inhibition might be conditioned to the synchronized firing of spiny neurons. Finally, dopamine exerts a potentially important role regulating the extent of lateral inhibition.

show abstract

Section: Ipscs From Axon Collateralsmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Briefly, double in situ hybridization with a [ 35 S]UTPlabeled Nur77 and a non-radioactive dioxygenin (Dig)-labeled preprotachykinin, which produces substance P (SP), was performed (Krause et al, 1987). The SP neuropeptide is expressed in the same cell population as DYN and was chosen as a marker of the direct striatal pathway because it possesses a higher basal expression than DYN (Gerfen and Young, 1988). The SP probe was obtained from a 200 bp fragment (from nucleotides 78 to 277) of the rat preprotachykinin mRNA into pGEM-4Z vector.…”

Section: Double In Situ Hybridization Proceduresmentioning

confidence: 99%

Nur77 mRNA levels and L-Dopa-induced dyskinesias in MPTP monkeys treated with docosahexaenoic acid

Mahmoudi

Samadi

Gilbert

et al. 2009

Neurobiology of Disease

View full text Add to dashboard Cite

We have previously shown that docosahexaenoic acid (DHA) significantly reduced L-Dopainduced dyskinesia (LID) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkeys (Samadi et al., Ann. Neurol. 59:282-288, 2006). In the present study, we measured for the first time mRNA levels of Nur77, an orphan nuclear receptor that participates to adaptive and/or aberrant dopamine-related behaviors, and retinoid X receptor γ1 (RXRγ1), a putative brain receptor for DHA and transcriptional partner of Nur77, in MPTP monkeys treated with L-Dopa and DHA. The RXRγ1 mRNA is strongly expressed in monkey caudate nucleus and putamen, but no change in levels of RXRγ1 was observed following MPTP and L-Dopa treatments. On the other hand, denervation reduced Nur77 mRNA levels, whereas chronic L-Dopa treatment strongly induced Nur77 transcripts. These modulations are taking placed in substance P positive cells and are associated with both caudate-putamen matrix and striosome compartments. Interestingly, combination of L-Dopa with DHA further increases Nur77 mRNA levels in the anterior caudateputamen, and mainly in striosomes. This is accompanied by a significant inverse correlation between Nur77 mRNA levels and dyskinetic scores. Taken together, our results show that Nur77 expression is modulated following dopamine denervation and chronic L-Dopa therapy in a nonhuman primate model of Parkinson's disease, and suggest that strong modulation of Nur77 expression might be linked to a reduced risk to develop LIDs.

show abstract

“…In the central nervous system, the striatum (caudate, putamen, nucleus accumbens) is among the brain areas with the highest levels of enkephalin, which is mostly expressed in striatopallidal neurons [10,24]. Upon release, enkephalin interacts preferentially with delta and mu opiate receptors [22] and exerts a negative feedback mechanism to regulate the responsiveness of striatopallidal neurons [24].…”

Section: Introductionmentioning

confidence: 99%

Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways

Konradi

Macı́as

Dudman

et al. 2003

Molecular Brain Research

View full text Add to dashboard Cite

Enkephalin modulates striatal function, thereby affecting motor performance and addictive behaviors. The proenkephalin gene is also used as a model to study cyclic AMP-mediated gene expression in striatal neurons. The second messenger pathway leading to proenkephalin expression demonstrates how cyclic AMP pathways are synchronized with depolarization. We show that cyclic AMP-mediated regulation of the proenkephalin gene is dependent on the activity of L-type Ca 2+ channels. Inhibition of L-type Ca 2+ channels blocks forskolin-mediated induction of proenkephalin. The Ca 2+ -activated kinase, Ca 2+ /calmodulin kinase, as well as the cyclic AMPactivated kinase, protein kinase A (PKA), are both necessary for the induction of the proenkephalin promoter. Similarly, both kinases are needed for the L-type Ca 2+ channel-mediated induction of proenkephalin. This synchronization of second messenger pathways provides a coincidence mechanism that gates proenkephalin synthesis in striatal neurons, ensuring that levels are increased only in the presence of activated PKA and depolarization.

show abstract

Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing study

Cited by 613 publications

References 33 publications

Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum

Dopaminergic Modulation of Axon Collaterals Interconnecting Spiny Neurons of the Rat Striatum

Nur77 mRNA levels and L-Dopa-induced dyskinesias in MPTP monkeys treated with docosahexaenoic acid

Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways

Contact Info

Product

Resources

About