Distribution of tangles and threads in the cerebral cortex in progressive supranuclear palsy

Hanihara, Tokiji; Amano, Naoji; Takahashi, Tatsuya; Nagatomo, H; Yagashita, S

doi:10.1111/j.1365-2990.1995.tb01066.x

Cited by 43 publications

(13 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The important role of cortical pathology in the genesis of PSP symptoms was identified some time ago [7,8,24,28,43]. Only a few studies have since investigated relationships between cortical pathology and clinical features [14,31,46].…”

Section: Introductionmentioning

confidence: 99%

The relationship between clinical and pathological variables in Richardson’s syndrome

et al. 2011

View full text Add to dashboard Cite

In order to determine the relationship between regional neuropathology and severity of clinical features in Richardson's syndrome (PSP-RS), the following hypotheses were tested: (1) executive dysfunction relates to prefrontal pathology; (2) language difficulties to pathology in Broca's area and/or the perirhinal cortex; and (3) visuospatial impairment to pathology in the supramarginal region. A prospectively studied case series of brain donors at a specialist clinic in Addenbrooke's Hospital Cambridge, UK, were examined. All those fulfilling postmortem criteria for PSP-RS and their last cognitive assessment within 24 months of death (N = 11/25) were included. The degree of regional neuronal loss and neuronal tau deposition across a number of cortical brain regions was performed and compared to 10 age- and sex-matched controls from the Sydney Brain Bank. Stepwise multiple linear regressions were used to determine the neuropathological correlates to cognitive scores and revealed the following. Executive dysfunction, as indexed by letter fluency, related to the degree of tau deposition in the superior frontal gyrus and supramarginal cortices (p < 0.020), language deficits related to neuron loss in the perirhinal gyrus (p < 0.001) and tau deposition in Broca's area (p = 0.020), while visuospatial dysfunction and global cognitive impairment related to tau deposition in the supramarginal gyrus (p < 0.007). The severity of cognitive deficits relate to regional cortical tau deposition in PSP-RS, although language impairment related to neuronal loss in the perirhinal region. Global cognitive dysfunction related most to the severity of tau deposition in the supramarginal gyrus warranting further research on the role of this brain region in PSP-RS.

show abstract

Section: Introductionmentioning

confidence: 99%

The relationship between clinical and pathological variables in Richardson’s syndrome

et al. 2011

View full text Add to dashboard Cite

show abstract

“…All 11 cases met the revised NINDS histological criteria for PSP, and arteriosclerosis was minimal or absent [13]. Palatal myoclonus was not observed in any of the patients [14].…”

Section: Methodsmentioning

confidence: 92%

Hypertrophy of the Inferior Olivary Nucleus in Patients with Progressive Supranuclear Palsy

Hanihara¹,

Amano

Takahashi³

et al. 1998

Eur Neurol

View full text Add to dashboard Cite

Hypertrophic changes in the inferior olivary nuclei have been occasionally described in patients with progressive supranuclear palsy (PSP). To elucidate the incidence of olivary hypertrophy, we investigated morphologically the olives and their associated pathways in 20 autopsied cases: 11 cases of PSP, 3 cases of Machado-Joseph disease and 6 cases of dentatorubropallidoluysian atrophy (DRPLA) as control diseases that usually exhibited lesions of the cerebellofugal pathway. Olivary hypertrophy was observed in 5 of 11 PSP cases, but not in the other diseases, except for 1 case of DRPLA with an old infarct in the dentate nucleus. In the olivopetal pathway, grumose degeneration of the dentate nucleus and mild neuronal loss in the red nucleus were observed in all patients with PSP and in the control subjects. Atrophy and fibrillary gliosis of the tegmentum of the pons, including that of the bilateral central tegmental tracts, were observed in all patients with PSP, more severe in the cases with hypertrophic neurons in the olives. We speculate that a lesion that involves the central tegmental tracts may play a major role in inducing hypertrophy of the olives in patients with PSP.

show abstract

“…PSP pathology is characterized by the abnormal accumulation of tau protein accompanied by neuronal loss and gliosis, mainly in subcortical structures [29]. The striato-frontal dysfunction leads to dramatic deficits in planning, monitoring and recall, which evolves into dementia in PSP patients [30,31].…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological study of amyotrophic lateral sclerosis and parkinsonism-dementia complex in Kii peninsula, Japan

et al. 2014

View full text Add to dashboard Cite

BackgroundThe Kii peninsula of Japan is one of the foci of amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS/PDC) in the world. The purpose of this study is to clarify the neuropsychological features of the patients with ALS/PDC of the Kii peninsula (Kii ALS/PDC).MethodsThe medical interview was done on 13 patients with Kii ALS/PDC, 12 patients with Alzheimer’s disease, 10 patients with progressive supranuclear palsy, 10 patients with frontotemporal lobar degeneration and 10 patients with dementia with Lewy bodies. These patients and their carer/spouse were asked to report any history of abulia-apathy, hallucination, personality change and other variety of symptoms. Patients also underwent brain magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), and neuropsychological tests comprising the Mini Mental State Examination, Raven’s Colored Progressive Matrices, verbal fluency, and Paired-Associate Word Learning Test and some of them were assessed with the Frontal Assessment Battery (FAB).ResultsAll patients with Kii ALS/PDC had cognitive dysfunction including abulia-apathy, bradyphrenia, hallucination, decrease of extraversion, disorientation, and delayed reaction time. Brain MRI showed atrophy of the frontal and/or temporal lobes, and SPECT revealed a decrease in cerebral blood flow of the frontal and/or temporal lobes in all patients with Kii ALS/PDC. Disorientation, difficulty in word recall, delayed reaction time, and low FAB score were recognized in Kii ALS/PDC patients with cognitive dysfunction.ConclusionsThe core neuropsychological features of the patients with Kii ALS/PDC were characterized by marked abulia-apathy, bradyphrenia, and hallucination.

show abstract

Distribution of tangles and threads in the cerebral cortex in progressive supranuclear palsy

Cited by 43 publications

References 26 publications

The relationship between clinical and pathological variables in Richardson’s syndrome

The relationship between clinical and pathological variables in Richardson’s syndrome

Hypertrophy of the Inferior Olivary Nucleus in Patients with Progressive Supranuclear Palsy

Neuropsychological study of amyotrophic lateral sclerosis and parkinsonism-dementia complex in Kii peninsula, Japan

Contact Info

Product

Resources

About