Distribution of the Carbohydrate Polymer in ¹⁴C‐labelled Iron‐poly (sorbitol‐gluconic acid) complex after Intramuscular Administration in Normal and Anaemic Rats

Abstract

The carbohydrate polymer in an iron-poly (sorbitol-gluconic acid) complex was prepared by using uniformly labelled 14C-sorbitol or 14C-gluconic acid. The distribution of these complexes 7, 14 and 28 days after administration has been followed in non-anaemic and anaemic rats. Most of the 14C from the labelled complexes was found in the expired CO,, faeces and urine. Twenty-eight days after injection of 14C-labelled FerastraiB, less than 13 % of the given dose of either 14C-sorbitol or 14C-gluconic acid labelled preparation could be found in the body. There was no specific accumulation of l4C in any organ except in the bones, where 3 % of the given dose could be seen 28 days after 14C-gluconic acid labelled Ferastral to both non-anaemic and anaemic animals.Key-words: iron-poly (sorbitol-gluconic acid) complex -FerastralBparenteral iron preparation -14C-labelled polymerdistribution of the polymer Ferastral: Proceedings of a conference

Disposition in Rats of the Carbohydrate Polymer in Ferastral®— an Iron‐poly (sorbitol‐gluconic acid) complex

“…Consequently, the reticulo-endothelial system, mainly liver and bone marrow would be instrumental in effecting the release and perhaps, to a certain extent, the degradation of this fraction of the carbohydrate moiety. Hence, the hepatic metabolic contribution implied by the findings here plus the uptake of I4C-label by bone marrow demonstrated by Gagner-Milchert & Lindvall ( 1977), provide experimental support for reticulo-endothelial contribution to the total disposition picture.…”

“…The organic moiety of the new parenteral iron preparation, FerastraP, is a polymeric species synthesized by cross-linking sorbitol and gluconic acid using epichlorohydrin. The iron complex obtained from the reaction between this polymer and ferric iron is both stable and with satisfactory iron utilization properties (Dahlberg et al 1971, Domeij et al 1977, Lake-Bakaar & Lindvall 1977, Andersson & Grafford 1977, Gagner-Milchert & Lindvall 1977.…”