Distribution of the Receptor for Advanced Glycation End Products Gene Polymorphisms in Patients With Chronic Periodontitis: A Preliminary Study

Abstract

We can speculate that susceptibility to the development of chronic periodontitis could be influenced by the 1704G/T polymorphism of the RAGE gene, independently of diabetes.

Rage gene promoter polymorphisms and diabetic retinopathy in a clinic-based population from South India

“…Variations in the RAGE gene have been identified and screened for association with DR and other diseases. [31][32][33] Of the many polymorphisms that have been screened, the À429 and À374 are considered important, since these polymorphisms are reported to increase the RAGE gene transcript, which will augment increased AGE binding to cells and as a result lead to an altered signaling cascade. The G82S polymorphism has also been studied in various populations, which is yet another important polymorphism previously studied in this population.…”

“…In conclusion, our results show an association of À374 T/A polymorphism with NPDR, which is inconsistent to the Slovakian study, and the Chinese study which did not show any association between these promoter polymorphisms and DR. 20,21 Other RAGE gene polymorphisms such as G82S, G1704T, A2484G, and G2245A, which have been studied extensively in different populations, [32][33][34][35][36][37] need to be studied in this population to understand the impact of these variations on the onset and progression of DR. Ethnic variations, if any, that may have been present in the study subjects were tested using genomic controls that did not show allele frequency variation among the groups, suggesting strongly that these results are not an artefact due to population substructuring.…”

Advanced Glycation and Lipoxidation End Products–Amplifiers of Inflammation: The Role of Food

“…118 RAGE and AGE/ALE-induced apoptosis and enhanced loss of fibroblasts and osteoblasts are also regarded as major pathogenic factors in periodontal pathology, especially in chronic periodontitis. 119 A 50% increase in RAGE mRNA is observed in gingiva of diabetic patients compared with controls (p Ͻ .05). 120 Urogenital disorders.…”

Vitamin D receptor gene polymorphism is associated with chronic periodontitis

“…In the last several years, reports concerning the susceptibility gene for CP have been accumulating as follows; interleukin-1 (Kornman et al, 1997;Gore et al, 1998;Mark et al, 2000;Shimpuku and Ohura, 2001), receptor for advanced glycation end products (Holla et al, 2001), plasminogen-activatorinhibitor-1 (Holla et al, 2002) and immunoglobulin G Fc receptor (Kobayashi et al, 1997). However, the search for the susceptibility gene for CP is rather poorly developed in comparison with that for other multi-factorial diseases such as diabetes and hypertension.…”