Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors

Differential Regulation of the Mesoaccumbens Dopamine Circuit by Serotonin2C Receptors in the Ventral Tegmental Area and the Nucleus Accumbens: An In Vivo Microdialysis Study with Cocaine

“…Specifically, although the role of NAc 5-HT 2C R remains to be unravelled because of the existence of opposite concentration-dependent effects, our findings do not support the previous proposal that the 5-HT 2C R resident in the VTA may primarily account for the central inhibitory control this receptor protein exerts over accumbal DA release . Conversely, our findings provide support to the idea that central 5-HT 2C R inhibitory control of mesoaccumbens DA pathway may be considered as a composite response Cunningham, 2002, 2003) involving different 5-HT 2C R populations located within multiple brain areas (Clemett et al, 2000;Pompeiano et al, 1994) which are known to provide important efferent control of this DA pathway, such as the prefrontal cortex (Carr et al, 1999;Carr and Sesack, 2000), the hippocampus (Sesack and Pickel, 1990), and the amygdala (McDonald, 1991). This conclusion is further supported by the fact that, in contrast to their systemic effects Gobert et al, 2000;Navailles et al, 2006a), intra-VTA or intra-NAc administration of 5-HT 2C R ligands has no influence on basal DA release in the NAc (Navailles et al, 2006b;present results).…”

“…During recent years, numerous studies have focused on the role of the serotonergic2C receptor (5-HT 2C R) in the modulation of this DA pathway and its potential to control cocaine dependence (Bubar and Cunningham, 2006;Di Matteo et al, 2002;Higgins and Fletcher, 2003). Indeed, 5-HT 2C Rs are densely localized in brain regions containing DA cell bodies (VTA) and terminals (NAc) (Bubar and Cunningham, 2006;Clemett et al, 2000;Pazos et al, 1985;Pompeiano et al, 1994), and are known to modulate DA-dependent behavioral and neurochemical effects induced by cocaine (Fletcher et al, 2002(Fletcher et al, , 2006Grottick et al, 2000;McCreary and Cunningham, 1999;Navailles et al, 2004). Specifically, the systemic administration of the 5-HT 2C R agonist Ro 60-0175, and the 5-HT 2C R antagonist SB 242084 has been shown to respectively inhibit and potentiate cocaineinduced behaviors including its hypermotive and rewarding effects (Fletcher et al, 2002(Fletcher et al, , 2006Grottick et al, 2000).…”

In vivo modulation of vagal‐identified dorsal medullary neurones by activation of different 5‐Hydroxytryptamine2 receptors in rats

“…Binding sites for ketanserin (Pazos et al, 1985;Dashwood et al, 1988) and both 5-HT 2A and 5-HT 2C receptors have been localized in the NTS (Pompeiano et al, 1994). However, the presence of 5-HT 2B receptors in rat brain has been disputed, though they are found in the spinal cord (Kursar et al, 1992;Helton et al, 1994).…”

Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

“…Autoradiographic binding studies indicate that 5-HT2A/C receptors are located in 5-HT terminal regions, and are particularly dense in the deeper cortical layers, including the prefrontal and anterior cingulate cortices Fischette et al, 1987). More recently, immunohistochemical (Willins et al, 1997;Cornea-Hebert et al, 1999) and in situ hybridization studies (Pompeiano et al, 1994;Wright et al, 1995) have also demonstrated high levels of 5-HT2A receptors in the rat PFC. Multiple laboratories have shown that prefrontal 5-HT2A receptors are localized primarily to the apical dendrites of pyramidal neurons with a minor localization to parvalbumin-labeled GABA interneurons (Willins et al, 1997;Hamada et al, 1998;Jakab and Goldman-Rakic, 1998;Cornea-Hebert et al, 1999;Miner et al, 2003).…”