Distribution of various nickel compounds in rat organs after oral administration

Ishimatsu, Sumiyo; Kawamoto, Toshihiro; Matsuno, Koji; Kodama, Yasushi

doi:10.1007/bf02789001

Cited by 43 publications

(21 citation statements)

References 7 publications

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“…A distinct transfer of Nickel (significantly different than control) was observed in kidney and lung (Ishimatsu et al, 1995). A distinct transfer of Nickel (significantly different than control) was observed in kidney and lung (Ishimatsu et al, 1995).…”

Section: Distributionmentioning

confidence: 73%

“…After oral administration of Nickel, no renal failure was detected (Koizumi et al 2005), the increase in urinary Nickel concentration occurred in a dose dependent manner, and soluble Ni compounds were excreted with urine within 72 hours after a single oral administration (Ishimatsu et al, 1995;Koizumi et al 2005;Janicka and Cempel, 2003). This is confirmed by Nielsen et al, (1993) who reported that up to 20 h after single oral administration of doses comparable to the human dietary intake, Nickel retention was highest in the kidneys.…”

Section: Metabolism and Eliminationmentioning

confidence: 99%

See 1 more Smart Citation

Collate literature data on toxicity of Chromium (Cr) and Nickel (Ni) in experimental animals and humans

Casalegno¹,

Schifanella²,

Zennaro³

et al. 2015

EFSA Supporting Publications

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Literature data on Chromium show that trivalent chromium has low acute and long term toxicity whilst hexavalent chromium is acutely toxic and produces long term effects on hematological parameters and liver. Continuous exposure to high concentrations of hexavalent chromium in drinking water results in intestinal tumors in mice but not rats. However, evidence of the carcinogenic potential of chromium has been demonstrated in rats but not consistently in mice. Cr (III) organic complexes (chromium picolinate) did not show evident adverse effects after repeated oral exposure. Both in vitro and in vivo data show that trivalent chromium is not genotoxic whilst hexavalent chromium is genotoxic. Chromium has been shown to affect sperm, estrous cycle and fetal development. Human toxicity data reveals mixed results but there is some evidence that hexavalent chromium can increase the risk of cancer. Data on Nickel show that nickel soluble compounds (nickel sulphate, nickel chloride or nickel nitrate) have acute and long term toxicity and produce oxidative stress and long term effects on liver. Less soluble compounds (nickel sulfides or nickel oxides) are less toxic. Nickel shows genotoxic effects both in vitro and in vivo. Only a limited number of studies on carcinogenic effects after oral exposure to nickel compounds are available. These studies showed no neoplastic effects in rats after oral administration. Nickel has been shown to affect sperm, live litter size and post-implantation loss. Teratogenic effects are reported on Amphibian embryos. Nickel can affect neurodifferentiation, the T-cell system and suppress the activity of natural killer cells. Human data reveals that nickel is excreted in the urine following oral exposure and that this increases with increasing age. There is some evidence that nickel might promote oral cancer etiology but no clear evidence that nickel can increase the risk of respiratory cancer.

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Section: Distributionmentioning

confidence: 73%

Section: Metabolism and Eliminationmentioning

confidence: 99%

Collate literature data on toxicity of Chromium (Cr) and Nickel (Ni) in experimental animals and humans

Casalegno¹,

Schifanella²,

Zennaro³

et al. 2015

EFSA Supporting Publications

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show abstract

“…NiCl) and observed a 3-6 % excretion in the urine within 48 hours from administration, regardless of the administered dose. Ishimatsu et al (1995) showed that the GI absorption of Ni correlates with the water solubility of the administered Ni-containing substance. Wistar rats were administered a single dose of 10 mg Ni as metallic Ni, (green or black) Ni oxide, Ni subsulfide, Ni sulfide, Ni sulfate, Ni chloride or Ni nitrate.…”

Section: Other Exposuresmentioning

confidence: 99%

Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water

Publication¹

2015

EFS2

119

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EFSA received a request from the Hellenic Food Authority (EFET) for a scientific opinion on the risk to human health from the presence of nickel (Ni) in food, particularly in vegetables. The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) decided to extend the risk assessment also to drinking water. The reproductive and developmental toxicity in experimental animals was selected as the critical effect for the assessment of chronic effects of Ni. A tolerable daily intake of 2.8 µg Ni/kg body weight (b.w.) per day was derived from a lower 95 % confidence limit for a benchmark dose at 10 % extra risk (BMDL 10 ) of 0.28 mg/kg b.w. for post-implantation fetal loss in rats. The current dietary exposure to Ni raises concern when considering the mean and 95th percentile chronic exposure levels for all different age groups. The systemic contact dermatitis (SCD) elicited in Ni-sensitive humans after oral exposure to Ni was selected as the critical effect suitable for the assessment of acute effects of Ni. A lowest BMDL 10 of 1.1 µg Ni/kg b.w. was derived for the incidence of SCD following oral exposure to Ni of human volunteers. The CONTAM Panel applied a margin of exposure (MOE) approach and considered an MOE of 10 to be indicative of a low health concern. The MOEs calculated considering the estimated mean and the 95th percentile acute exposure levels were considerably below 10 for all age groups. Overall, the CONTAM Panel concluded that, at the current levels of acute dietary exposure to Ni, there is a concern that Ni-sensitized individuals may develop eczematous flare-up skin reactions. The CONTAM Panel noted the need for mechanistic studies to assess the human relevance of the effects on reproduction and development observed in experimental animals and for additional studies on human absorption of nickel from food, for example in combination with duplicate diet studies. Following a call for data on Ni levels in food and drinking water (water intended for human consumption and mineral waters), a total of 18 885 food samples and 25 700 drinking water samples were available in the final dataset to estimate dietary exposure to nickel. No speciation data were provided. Samples were collected between 2003 and 2012 in 15 different European countries, with almost 80 % of the total collected in one Member State. The most reported analytical methods were inductively coupled plasma-mass spectrometry (ICP-MS) and atomic absorption spectrometry (AAS), that represented 54 % and 42 % of the methods reported, respectively. The highest sensitivity was reported for the analysis of drinking water with a limit of quantification (LOQ) of 0.001 µg/L (for both ICP-MS and AAS). In food, ICP-MS showed the lowest LOQ for the analysis of 'Alcoholic beverages' (0.002 µg/kg) while the lowest LOQ reported with AAS was 1 µg/kg for samples of 'Fish and seafood' and 'Sugar and confectionery'. In the final dataset, left-censored data represented 66 % of the analytical results, with 35 % in food samples and 89 % in drinking water sa...

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“…Prolonged exposure of rats to nickel in drinking water increased nickel levels in tissues and body fl uids; the highest level was found in the liver, followed by kidney ϭ blood Ͼ serum Ͼ testes Ͼ urine Ͼ ovaries [73]. Oral ingestion of insoluble nickel compounds resulted in much lower intestinal absorption [74]. Inhalation of nickel carbonyl by animals increases the lung and body burden of nickel that is subsequently excreted, mainly in urine [23,75].…”

Section: Uptake Distribution Metabolism and Excretionmentioning

confidence: 99%

Nickel Toxicity and Carcinogenesis

Kasprzak

Salnikow

2007

Nickel and Its Surprising Impact in Nature

123

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Distribution of various nickel compounds in rat organs after oral administration

Cited by 43 publications

References 7 publications

Collate literature data on toxicity of Chromium (Cr) and Nickel (Ni) in experimental animals and humans

Collate literature data on toxicity of Chromium (Cr) and Nickel (Ni) in experimental animals and humans

Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water

Nickel Toxicity and Carcinogenesis

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