Nickel Toxicity and Carcinogenesis

Kasprzak, Kazimierz S.; Salnikow, Konstantin

doi:10.1002/9780470028131.ch17

Cited by 95 publications

(129 citation statements)

References 233 publications

(344 reference statements)

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“…The variation of the world mine production of nickel over the last 40 years [20][21][22]. On the other hand, the toxicity and carcinogenicity of high doses of Ni are well documented and depend mainly on its potential to damage proteins and nucleic acids [23]. The obtained results show that the content of Ni ranges from 25.7 to 71 mg/kg with an average of 46 mg/kg.…”

Section: Contents Of Contaminants In Soilmentioning

confidence: 99%

Assessment of industrial contamination of agricultural soil adjacent to Sadat City, Egypt

Badawy

Chepurchenko

Samman

et al. 2016

Ecological Chemistry and Engineering S

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Assessment of the environmental impact of El Sadat City, a Cairo satellite, known for its clustered enterprises, on the neighbourhood water supply El Manashi Tawfikia Canal was undertaken through soil analysis. A total of 20 agricultural soil samples were collected along the El Manashi Tawfikia Canal. Neutron activation analysis was implemented to determine heavy metal contents of such elements as As, Ba, Co, Cr, Ni, and Zn. Multivariate statistical analysis was applied to the results obtained. The metal pollution index and enrichment factor were calculated. It was shown that the content of toxic heavy metals in soil samples does not exceed the worldwide-published values, except arsenic which considerably exceeds normalized to the content of the same element in the Upper Continental Crust. The metal pollution index is high compared with the calculated ones for similar soil samples from the Nile Delta, and the enrichment factor varied from moderate to high enrichment (5 < EF > 10).

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Section: Contents Of Contaminants In Soilmentioning

confidence: 99%

Assessment of industrial contamination of agricultural soil adjacent to Sadat City, Egypt

Badawy

Chepurchenko

Samman

et al. 2016

Ecological Chemistry and Engineering S

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“…Nickel's oxidation powers are known to be enhanced when it binds to certain biomolecules, such as peptides. [19,[31][32][33][34][35][36] When this formation of 8oxoG was noted as a result of G oxidation at pH 11, the experiment was then carried forward to DNA at pH 5.5. The experiments on G alone were performed at pH 11 due to solubility issues.…”

Section: Nickel-mediated Oxidative Dna Damagementioning

confidence: 99%

Nickel(II)-catalysed oxidative guanine and DNA damage beyond 8-oxoguanine

Kelly

Whitaker

White

et al. 2007

Free Radical Biology and Medicine

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“…Increasing or decreasing levels of these elements in living tissues cause important effects on metabolism (Kızıler and Barutçu, 1997) and in some studies it is reported that both cadmium (Waalkes, 2003) and nickel (Kasprzak et al, 2003;Cavallo et al, 2003) are toxic and carcinogenic for human.…”

Section: Introductionmentioning

confidence: 99%

Nickel and Cadmium Concentrations in Plasma and Na+/K+ATPase Activities in Erythrocyte Membranes of the People Exposed to Cement Dust Emissions

Demir

Akar

Akyüz

et al. 2005

Environ Monit Assess

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The aim of this study was to determine the concentrations of nickel and cadmium in blood plasma of the people exposed to cement dust emissions and to investigate the effects of exposure period on the activities of Na+/K+ ATPase enzymes in their erythrocyte membranes. The study was carried out on people living in Eskişehir Cukurhisar rural area, located near a cement factory. Blood samples of the individuals residing in this area were taken from 80 subjects (30 for control) following a physical examination. The analysis of plasma samples showed that nickel concentrations in subject group were found to be significantly higher than those of the control group (p < 0.001). Cadmium concentrations were found to be within the reference values for both group and no difference was found between the subjects and controls (p > 0.05). Furthermore, no correlation was observed between the levels of Na+/K+ ATPase activity in erythrocyte membranes of the subject group and the ages of people living in the region (p > 0.05, r = 0.133). It was also observed that nickel concentrations increased by age (p < 0.001, r = 0.646) while no effect was observed in means of cadmium. Na+/K+ ATPase activities in the erythrocyte membranes were not affected. In conclusion although there was no difference between the Na+/K+ ATPase activity in means of age, there was an environmental pollution and may be it was due to the industrial plant.

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Nickel Toxicity and Carcinogenesis

Cited by 95 publications

References 233 publications

Assessment of industrial contamination of agricultural soil adjacent to Sadat City, Egypt

Assessment of industrial contamination of agricultural soil adjacent to Sadat City, Egypt

Nickel(II)-catalysed oxidative guanine and DNA damage beyond 8-oxoguanine

Nickel and Cadmium Concentrations in Plasma and Na+/K+ATPase Activities in Erythrocyte Membranes of the People Exposed to Cement Dust Emissions

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