1977
DOI: 10.1001/jama.237.23.2504
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Distribution pattern of metastatic bone disease. A need for total body skeletal image

Abstract: Distribution patterns of metastatic bone disease in 62 patients with soft-tissue cancers showed that 60% of bone lesions were located in the axial and 40% in the appendicular skeleton. Thirteen percent of the lesions were in appendicular regions not usually included in routine imaging studies. The majority of the metastatic skeletal lesions were clinically asymptomatic. The serum alkaline phosphatase level is a poor indicator of early bone metastases.

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Cited by 53 publications
(44 citation statements)
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“…Malignant disease in the axial skeleton The vertebral column and pelvis are the most frequent sites of metastatic bone disease because of their high red marrow content [14], and, consequently, accurate detection of metastases at these sites is of critical clinical importance in staging of cancer patients. The detection of metastases in the spine may be complicated by the presence of coexisting pathological conditions, such as severe degenerative disease and compression fractures, which can make firm diagnosis of malignant disease at this site difficult [15] (Figures 1 and 2).…”
Section: Applications In Musculoskeletal Radiologymentioning
confidence: 99%
“…Malignant disease in the axial skeleton The vertebral column and pelvis are the most frequent sites of metastatic bone disease because of their high red marrow content [14], and, consequently, accurate detection of metastases at these sites is of critical clinical importance in staging of cancer patients. The detection of metastases in the spine may be complicated by the presence of coexisting pathological conditions, such as severe degenerative disease and compression fractures, which can make firm diagnosis of malignant disease at this site difficult [15] (Figures 1 and 2).…”
Section: Applications In Musculoskeletal Radiologymentioning
confidence: 99%
“…Despite the frequency of vertebral metastases, the intervertebral disc is usually spared and preserves its normal structure even after extensive collapse of the vertebral body by neoplastic tissue [1,4,10,13]. A number of possible explanations for the disc's resistance to metastatic cancer have been proposed [2,3,32].…”
Section: Introductionmentioning
confidence: 99%
“…19,20 Unfortunately, metastatic disease is typically wide-spread by the time patients present symptomatically to the clinic. 22 Once symptoms present, delays in diagnosis can be significant.…”
Section: Discussionmentioning
confidence: 99%