Distribution profile of gadolinium in gadolinium chelate-treated renally-impaired rats: Role of pharmaceutical formulation

Fretellier, Nathalie; Salhi, Mariem; Schroeder, Josef; Siegmund, Heiko; Chevalier, Thibaut; Bruneval, Patrick; Jestin-Mayer, Gaëlle; Delaloge, Francette; Factor, Cécile; Mayer, Jean-François; Fabicki, Jean-Michel; Robic, Caroline; Bonnemain, Bruno; Idée, Jean‐Marc; Corot, Claire

doi:10.1016/j.ejps.2015.02.016

Cited by 11 publications

(8 citation statements)

References 41 publications

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“…Previous studies have reported greater accumulation in tissue of linear agents than of macrocyclic agents . In contrast, Tweedle et al reported greater accumulation of gadoteric acid in liver tissue between 5 minutes and 24 hours following administration of gadodiamide and gadoteric acid .…”

Section: Discussionmentioning

confidence: 84%

“…Previous studies have reported greater accumulation in tissue of linear agents than of macrocyclic agents. 23,29,30 In contrast, Tweedle et al reported greater accumulation of gadoteric acid in liver tissue between 5 minutes and 24 hours following administration of gadodiamide and gadoteric acid. 31 However, in that study a greater decrease was determined in gadoteric acid accumulation in liver tissue compared to gadodiamide after the first day, and gadodiamide accumulation was subsequently greater than that of gadoteric acid.…”

Section: Discussionmentioning

confidence: 92%

“…Preparations were scored by two different histopathologists (L.T., with 10 years' experience, and T.M. 8 years' experience) as mild (1), moderate (11), severe (111), or very severe (1111) 30 ( Table 2).…”

Section: Semiquantitative Analysismentioning

confidence: 99%

See 2 more Smart Citations

Effects of gadolinium‐based MRI contrast agents on liver tissue

Mercantepe

Tümkaya

Çeliker

et al. 2018

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 92%

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Effects of gadolinium‐based MRI contrast agents on liver tissue

Mercantepe

Tümkaya

Çeliker

et al. 2018

Magnetic Resonance Imaging

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“…Gadolinium (Gd) chelates, a low molecular weight marker, has found immense application in tissue contrast and diagnostic efficiency in magnetic resonance scans by prolonging the relaxation rate (1/T 1 ) of fluid protons (Fretellier et al 2015). But one key issue with MR imaging is the rapid clearance and non-specific distribution of Gd and this has necessitated the development of smart delivery systems to ferry contrast agents into specific tissue or disease of interest (Liu and Zhang 2012).…”

Section: Discussionmentioning

confidence: 99%

Comparative study on contrast enhancement of Magnevist and Magnevist-loaded nanoparticles in pancreatic cancer PDX model monitored by MRI

et al. 2020

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Background: The aim of this study was to compare contrast enhancement of Magnevist ® (gadopentate dimeglumine (Mag)) to that of PEGylated Magnevist ®-loaded liposomal nanoparticles (Mag-Lnps) in pancreatic cancer patientderived xenograft (PDX) mouse model via magnetic resonance imaging (MRI). Methods: Mag-Lnps formulated by thin-film hydration and extrusion was characterized for the particle size and zeta potential. A 21.1 T vertical magnet was used for all MRI. The magnet was equipped with a Bruker Advance console and ParaVision 6.1 acquisitions software. Mag-Lnps phantoms were prepared and imaged with a 10-mm birdcage coil. For in vivo imaging, animals were sedated and injected with a single dose (4 mg/kg) of Mag or Mag-Lnps with Mag equivalent dose. Using a 33-mm inner diameter birdcage coil, T 1 maps were acquired, and signal to noise ratio (SNR) measured for 2 h. Results: Mag-Lnps phantoms showed a remarkable augmentation in contrast with Mag increment. However, in in vivo imaging, no significant difference in contrast was observed between Mag and MRI. While Mag-Lnps was observed to have fairly high tumor/muscle (T/M) ratio in the first 30 min, free Mag exhibited higher T/M ratio over the time-period between 30 and 120 min. Overall, there was no statistically significant difference between Mag and Mag-Lnp in rating MR image quality. Low payload of Mag entrapment by Lnps and restricted access of water (protons) to Mag-Lnps may have affected the performance of Mag-Lnps as an effective contrast agent. Conclusion: This study showed no significance difference in MRI contrast between Mag and Mag-Lnp pancreatic cancer PDX mouse models.

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“…Gadolinium compounds are used as diagnostic and theranostic agents [44,45,46]. Gadolinium contrast agents have been used to detect amyloid β-protein aggregates by MRI [47].…”

Section: Introductionmentioning

confidence: 99%

Distribution of Gadolinium in Rat Heart Studied by Fast Field Cycling Relaxometry and Imaging SIMS

Bonechi

Consumi

Matteucci

et al. 2019

IJMS

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Research on microcirculatory alterations in human heart disease is essential to understand the genesis of myocardial contractile dysfunction and its evolution towards heart failure. The use of contrast agents in magnetic resonance imaging is an important tool in medical diagnostics related to this dysfunction. Contrast agents significantly improve the imaging by enhancing the nuclear magnetic relaxation rates of water protons in the tissues where they are distributed. Gadolinium complexes are widely employed in clinical practice due to their high magnetic moment and relatively long electronic relaxation time. In this study, the behavior of gadolinium ion as a contrast agent was investigated by two complementary methods, relaxometry and secondary ion mass spectrometry. The study examined the distribution of blood flow within the microvascular network in ex vivo Langendorff isolated rat heart models, perfused with Omniscan® contrast agent. The combined use of secondary ion mass spectrometry and relaxometry allowed for both a qualitative mapping of agent distribution as well as the quantification of gadolinium ion concentration and persistence. This combination of a chemical mapping and temporal analysis of the molar concentration of gadolinium ion in heart tissue allows for new insights on the biomolecular mechanisms underlying the microcirculatory alterations in heart disease.

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Distribution profile of gadolinium in gadolinium chelate-treated renally-impaired rats: Role of pharmaceutical formulation

Cited by 11 publications

References 41 publications

Effects of gadolinium‐based MRI contrast agents on liver tissue

Effects of gadolinium‐based MRI contrast agents on liver tissue

Comparative study on contrast enhancement of Magnevist and Magnevist-loaded nanoparticles in pancreatic cancer PDX model monitored by MRI

Distribution of Gadolinium in Rat Heart Studied by Fast Field Cycling Relaxometry and Imaging SIMS

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