Distribution profile of paraoxonase phenotypes among the Gujaratis

Ab, Patel; Pal, Ramavati R.; Dewan, Aruna

doi:10.4103/0971-6866.34709

Cited by 6 publications

(2 citation statements)

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“…The capacity of paraoxonase to hydrolyze lipid peroxides was found to be the reverse of paraoxon hydrolytic activity, showing that phenotype A with low paraoxonase activity is more protective against lipid modification than phenotype B. The distribution of paraoxonase activity in the studied population was trimodal and presented low (type A), high (type B) and intermediate (type AB) activity, which is in accordance with other studies [ 14 , 38 , 39 ]. The odds ratio and the relative risk analysis showed that the patients with moderate ischemia are much more often characterized by phenotype A than phenotype B and the control group.…”

Section: Discussionsupporting

confidence: 90%

PON1 status evaluation in patients with chronic arterial occlusion of lower limbs due to atherosclerosis obliterans

Kasprzak¹,

Iskra²,

Majewski³

et al. 2014

aoms

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IntroductionHuman paraoxonase (PON1) is a calcium-dependent enzyme physically associated with HDL, and it is believed to contribute to the atheroprotective effect of HDL. The aim of the study was to evaluate PON1 status in patients with atherosclerosis obliterans as an effect of ischemia regarding its activity and phenotype distribution.Material and methodsThe study group consisted of patients with chronic arterial occlusion of the lower limbs due to atherosclerosis obliterans (AO). The patients were divided into two groups according to the degree of ischemia: moderate (MI), and critical (CI). The ratio of the hydrolysis of salt-stimulated PON1 activity to the hydrolysis of phenylacetate was used to assign individuals to one of three possible phenotypes (low activity – A, medium activity – AB, high activity – B). It was observed that PON1 arylesterase activity was affected by ischemia of the lower limbs depending on its degree.ResultsThe odds ratio and the relative risk analysis showed that the patients with moderate ischemia are much more often characterized by phenotype A than by phenotype B. The low activity phenotype A occurs over twice as often in patients with chronic ischemia of the lower limbs as in individuals from the control group (OR = 2.125; 1.96 to 3.776, p = 0.0143).ConclusionsThis study presents the low activity phenotype A in relation to the risk of ischemia of the lower limbs due to atherosclerosis and shows the potentially important role of PON1 in conclusion of the process leading to intensification of ischemia degree.

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Section: Discussionsupporting

confidence: 90%

PON1 status evaluation in patients with chronic arterial occlusion of lower limbs due to atherosclerosis obliterans

Kasprzak¹,

Iskra²,

Majewski³

et al. 2014

aoms

View full text Add to dashboard Cite

show abstract

“…La paraoxonasa es una enzima polimórfica que protege contra la exposición a POFs, ya que cataliza la hidrólisis de los ésteres de los POFs a compuestos excretables menos dañinos, tal como el paraoxón, (un metabolito de degradación del paratión) y del cual se deriva su nombre. La PON1 juega un rol principal en la susceptibilidad a la toxicidad a POFs y los individuos con actividad baja de paraoxonasa están más predispuestos a desarrollar los síntomas de la intoxicación (Patel et al, 2007).…”

Section: Introductionunclassified