Distribution Volume Assessment Compartment Modelling: Theoretic Phosphate Kinetics in Steady State Hemodialys Patients

Abstract

The 3-compartment model seems promising for prediction about plasma phosphate and holds the potential to be employed as a decision support tool and to enhance optimal dialysis prescriptions. Furthermore, the results provide specific suggestions about the distribution of phosphate in the body. Despite the promising results, further data and testing are necessary to validate the initial results.

Patient-Specific Modeling of Multicompartmental Fluid and Mass Exchange during Dialysis

“…Many mathematical models have been developed over the years for this purpose, mainly describing urea and some other solute kinetics during dialysis (15–17). More recently other mathematical models have been developed to predict fluid and mass transfer between patient body compartments during HD (18–27).…”

A Pseudo‐One Compartment Model of Phosphorus Kinetics During Hemodialysis: Further Supporting Evidence

“…A pseudo‐one compartment kinetic model can be derived from a conventional two compartment kinetic model by assuming the inaccessible tissue compartment is very large . With a conventional two compartment model , phosphorus mobilization to the proximal, accessible compartment is proportional to the difference in concentration between the inaccessible and accessible compartments, and the concentrations of both compartments decrease during a HD treatment. A pseudo‐one compartment kinetic model assumes that phosphorus mobilization to the accessible compartment is governed by the product of a patient‐specific phosphorus mobilization clearance ( K M ) times the difference between the pre‐dialysis serum and the instantaneous serum phosphorus concentration.…”

“…Several models of phosphorus kinetics during HD have been previously proposed , and these models differ in complexity and practicality. A pseudo‐one compartment model of phosphorus kinetics during HD and the immediate post‐dialysis rebound period has recently been proposed and its ability to describe intradialytic phosphorus kinetics in a large cohort of maintenance HD patients has been demonstrated .…”

Updating the Journal Sections for the Evolution of Research and Clinical Applications in Artificial Organs

“…Although personalized data have been obtained and used for a long time in modern medicine, as recently reported (8), today these possibilities are greatly enhanced thanks to the availability of genetic data and knowledge, electronic data records and computational models. Analysis of these data highly improves the identification of pathological mechanisms as well the prediction of different outcomes of therapeutic strategies in different patients (39)(40)(41). These conditions apply specially to patients in need of organ replacements.…”