Disturbance of intestinal permeability and its role in the development of cardiovascular complications in persons with inflammatory bowel diseases

Abstract

Inflammatory bowel diseases (IBD) are one of the most complex and significant problems of modern gastroenterology. The steady increase in morbidity, complex pathogenetic mechanisms of development, the presence of severe extra-intestinal manifestations and complications make this problem socially significant. The article presents modern views on some aspects of the pathogenesis of IBD. Currently, the key links in the development and progression of IBD, as well as the development of associated cardiovascular diseases are the state of the intestinal microbiota and the level of endotoxemia. The role of trimethylamine N-oxide as a factor in the early development of atherosclerosis in patients with IBD was determined.

Risk Associated with Antibiotic in Irritable Bowel Syndrome (IBS), Role of Microbiota and Future Aspects

“…Irritable bowel syndrome (IBS) is influenced by a myriad of risk factors. The development of IBS is associated with a variety of lifestyle factors such as smoking, body mass index (BMI), sleep duration, diet, physical activity, and alcohol consumption [3,4]. Mental disorders, namely anxiety and depression, as well as poor sleep quality, exhibit a significant association with an augmented risk of IBS [3,4,5].…”

“…The development of IBS is associated with a variety of lifestyle factors such as smoking, body mass index (BMI), sleep duration, diet, physical activity, and alcohol consumption [3,4]. Mental disorders, namely anxiety and depression, as well as poor sleep quality, exhibit a significant association with an augmented risk of IBS [3,4,5]. It is also believed that IBS creates a interaction between the brain and gut which is characterized by abdominal pain and irregular bowel movements.…”

“Host-gut microbiota” interactions in a case of eubiosis and dysbiosis

“…Дисбиоз зачастую сопровождается увеличением проницаемости кишечного барьера, что, в свою очередь, ведет к проникновению и накоплению в кровяном русле соединений микробного происхождения. Одним из основных механизмов нарушения проницаемости признается формирование «метаболической эндотоксемии», связанной с действием липополисахаридов (компонент клеточной стенки грамотрицательных бактерий), большие количества которых опосредуют активацию Toll-like рецепторов 4 типа и индуцируют синтез воспалительных цитокинов, приводя к вышеуказанным нарушениям [34][35][36][37].…”