Disturbances and Defects in Enamel Development

Simmelink, J.W.; Nygaard, V.K.

doi:10.1177/002203457905800223011

Cited by 9 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of light pigmentations on occlusal grooves in one of the molars from the group exposed to tetracycline (130 mg/kg), coincides with reports of several authors (15,16), who refer that dental alterations caused by these drugs are optically visible. Likewise, all molars exposed to tetracycline showed hypomineralized enamel, relating to several published studies (15,17), where it has been widely made known that tetracycline cause structural and functional changes in ameloblasts and in immature enamel; therefore, its use as positive control is valid to assess alterations in dental enamel caused by medications and other toxic substances in lab animals (15,17).…”

Section: Discussionsupporting

confidence: 90%

“…Likewise, all molars exposed to tetracycline showed hypomineralized enamel, relating to several published studies (15,17), where it has been widely made known that tetracycline cause structural and functional changes in ameloblasts and in immature enamel; therefore, its use as positive control is valid to assess alterations in dental enamel caused by medications and other toxic substances in lab animals (15,17). …”

Section: Discussionmentioning

confidence: 81%

See 1 more Smart Citation

Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats

Gottberg¹,

Berne²,

Quiñónez³

et al. 2014

Med Oral

View full text Add to dashboard Cite

Amoxicillin is an antibiotic widely prescribed; its most frequent side effects are gastrointestinal disorders and hypersensitivity reactions. Over the last 10 years studies have been published which suggest that amoxicillin may cause dental alterations similar to dental fluorosis. Never the less, the results are not conclusive, this is why it was planned the need to make controlled studies on test animals. Objectives: The purpose of this study was to determine the effect produced by amoxicillin prenatal administration on dental enamel in Wistar rats. Study Design: 12 pregnant adult rats were used distributed into five different groups: witness control (n=2) didn’t get any treatment; negative control (n=2) they were prescribed with saline solution; positive control (n=3) they were prescribed with tetracycline 130 mg/kg, and two groups (n=3 and n=2) treated with amoxicillin doses of 50 and 100 mg/kg respectively. The treatments were daily administered by mouth, from the 6th gestation day to the end of gestation. Twenty five days after they were born, the offspring were sacrificed with a sodium pentobarbital overdose, the mandible was dissected and the first lower molars were gotten. The samples were fixed in 10% formaldehyde solution and clinically and histologically observed to determine any enamel disorders. Results: hypomineralization was observed in every single sample of the tetracyclic and amoxicillin treated group 100 mg/kg, meanwhile only 50% from the group administered with 50 mg/kg amoxicillin showed this histological disorder. Conclusions: the side effect caused by amoxicillin on dental enamel was doses dependent. Key words:Amoxicillin, dental enamel, hypomineralization, Wistar rats.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 81%

Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats

Gottberg¹,

Berne²,

Quiñónez³

et al. 2014

Med Oral

View full text Add to dashboard Cite

show abstract

“…tetracyclines primarily affect amelogenesis at the TetracycHoes are rapidly incorporated into time of formation of the enamel tnatrix (16,26). many cells both in vivo and in vitro, antJ Observations at the ultrastructural level have ultrastructoral changes of secretory--ameloblasts indicated that interference with matrix form-in rats induced by these drugs have been atioti and initial mineralization might be a described (7,18,19). These obser\'ations were sequela to injur)' of secretor)' ameloblasts (14).…”

Section: High Doses Of Various Tetracyclines Inducementioning

confidence: 99%

Structural changes induced by tetracycline in secretory ameloblasts in young rats

Westergaard¹

1980

European J Oral Sciences

View full text Add to dashboard Cite

Westergaard, J.: Structural changes induced by tetracycline in secretory-ameSoblasts in yoong rats. Scand. J. Dent. Res. 1980: 88: 481-495. Abstract -The effects of tetracycline hydrochloiide (TC) on secretory-ameloblasts in mandibular incisors and Erst molars in young rats were investigated. The pathogenesis of the TC-induced ckanges was examined in hght and electron microscopes 6, 12, 24 and 96 h after a single imtraperitoneal injection of a high dose of TC (200 mgTC/kg body wt.) into 4-d-old animals. Secretorj' ameloblasts from non-injeeted animals served as controls. Cellular changes were observed in all teeth 6 h after injection. The changes increased with the postinjection period and after 96 ti they were so severe thai they were considered irreversible. The incipient changes of tbe ameloblasts comprised altered structure and location of the mitochondria, succeeded by dilated cisternae of endoplasmic reticulum arranged in short curled formations. Later on, distorted Golgi complexes were observed. Secretor>' grantiles appeared in I'arious numbers io the Golgi zone and in tiie Tomes' processes. In severely affected ameloblasts the cell nuclei showed an increased content of chromatin. Aiitopbagic vacuolcs and extracellular membrane bound fragments with cellular remnants were frequent, indicating death of some ofthe ameloblasts. .Areas of stippled seeretor\-material were obser\'ed along the formative enamel front and in extracellular spaces between the ameloblasts. In the 96-h group calcified bodies with a varying content of crystals were scattered betM'een the cells. Incisors and the molars displayed similar patterns of structural changes of tiie secretory ameloblasts; however, the changes developed earlier and became more severe in the molars.

show abstract

“…In laboratory animals, TC at dosage levels higher than 130 mg/kg is known to create disturbanees in enatnel and dentine formation when administered during odontogenesis. Thus, in rat enamel, TC has been shown to induce eellular alterations, to interfere with protein synthesis and with the delivery system of the secretory proteins (15). The action of TC upon the organic component of the mineralization process has been studied in vitro and it has been shown that TC uptake inhibits amorphous crystalline transformation (16).…”

Section: Discussionmentioning

confidence: 99%

Dental involvement in congenital chloride diarrhea

Kerebel¹,

Kerébel²,

Ajacques³

1984

J Oral Pathology Medicine

View full text Add to dashboard Cite

Dental involvement in a case of congenital chloride diarrhea (CCD) was studied using light microscopy of decalcified and undecalcified sections, microradiography and TEM. Mixed enamel lesions were found, involving gross liypoplasia at the cuspal level and hypocalcification occurring all over enamel. The hypocalcification resulted in the immature aspect of the prismatic enamel, porosities, amorphous areas, prominent incremental lines and round‐ended crystallites. A marked hypocalcification suggests a temporary break of amelogenesis likely related to acute episodes of the disease. Globular calcifications were associated with enamel formation. Dentinal hypoealcification was conspicuous and diffuse all over dentine. A globular mineralization pattern was revealed by the tretracycline (TC) stain which was well preserved in decalcified sections, thus indicating that TC uptake is related to the organic matrix. It is unlikely that TC alone is responsible for the hypocalcified areas which extended widely beyond the TC‐stained bands. It is suggested that TC uptale only adds to dental defects induced by the metabolic troubles of CCD.

show abstract

Disturbances and Defects in Enamel Development

Cited by 9 publications

References 22 publications

Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats

Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats

Structural changes induced by tetracycline in secretory ameloblasts in young rats

Dental involvement in congenital chloride diarrhea

Contact Info

Product

Resources

About