The objective of this study was to characterise Manafwa River floodplain and adjacent soils. Soil samples were collected from 0 - 20 cm depth in fallowed and cultivated Manafwa floodplain soils for laboratory analysis. Treatments included upland (control), floodplains fallowed for a year, floodplains fallowed for over a year, cultivated floodplains within 5 m and 50 m away from the river banks. Each treatment was replicated three times (3 blocks), and samples collected were analysed for K, Na, available P, total N, exchangeable acidity, pH, organic matter, moisture content, sand, silt, and clay. The soil sampling results were subjected to statistical Analysis of Variance (ANOVA) using Randomised Complete Block Design (RCBD), and the difference between treatment means were dictated using F-, student’s t and F-LSD/pairwise comparison tests. There was statistically no significant (p > 0.05) difference among different floodplains and uplands studied. Upland soils posted 71.67% for the highest pH and 0.09%, 0.87%, 9.74 ppm, 2.23 ppm and 7.264% for the lowest available N, organic matter, Phosphorous, Sodium and Moisture Content, respectively. Cultivated floodplain soil posted highest total P at 29.16 ppm and pH at 6.39% while fallowed floodplains lowest pH at 5.34%, highest available N at 0.32%, highest organic matter at 4.02%, highest K at 21.33%, highest Na at 13.93%, highest exchangeable acidity at 2.32 Cmol/Kg, highest clay content at 14.33%, lowest sand composition at 38.00%, highest silt composition at 54.8% and highest Moisture Content of 32.472%. As depicted by soil fertility analysis results, Manafwa River floodplain and adjacent soils have the capacity to accommodate and boost crop production and productivity. Any nutrients lost to leaching could be gained from subsequent fallowing and sustainable soil fertility management, proper drainage, crop rotation, adding organic manure, and cover cropping, among others