Disturbances of micronutrient and antioxidant status in diabetes

Strain, J. J.

doi:10.1079/pns19910073

Cited by 130 publications

(74 citation statements)

References 100 publications

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“…Free radicals have been shown to play an important role in the destruction of pancreatic islet beta cells in the (Oberley, 1988;Strain, 1991). Several antioxidants have also been shown to retard the destruction of islet cells in experimental diabetes (Slonim et al, 1982;Murthy et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Serum antioxidants and risk of non‐insulin dependent diabetes mellitus

et al. 1998

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Objective: To examine whether serum levels of a-tocopherol, b-carotene and retinol were associated with risk of non-insulin dependent diabetes mellitus (NIDDM). Design and subjects: The study design was a nested case-control study within a longitudinal population study. Serum levels of antioxidants were determined in 106 incident cases with non-insulin dependent diabetes mellitus detected on follow-up and 201 controls matched for sex, age and study region. Results: The incident cases had lower serum a-tocopherol and b-carotene levels than controls. The relative risk between the highest and lowest tertiles of serum a-tocopherol was 0.61 (95% con®dence interval (CI) 0.32±1.15), between the highest and lowest tertiles of serum b-carotene 0.45 (CI 0.22±0.92). Although the relative risk of highest compared with lowest tertile of serum a-tocopherol was not statistically signi®cant the inverse trend through the tertiles was (P`0.05). The decreasing risk of diabetes was particularly evident in the elderly, women, nonsmokers and the obese. However, adjustment for serum cholesterol, obesity, smoking and hypertension abolished the associations. The adjusted relative risks in relation to serum a-tocopherol and bcarotene (between highest and lowest tertiles) were 1.25 (CI 0.54±2.90) and 0.94 (CI 0.38±2.32), respectively. No associations were observed relating to serum retinol. Conclusions: High levels of a-tocopherol and b-carotene were found to be associated with decreased risk of noninsulin dependent diabetes mellitus, but the association disappeared after adjustment for cardiovascular risk factors.

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Section: Discussionmentioning

confidence: 99%

Serum antioxidants and risk of non‐insulin dependent diabetes mellitus

et al. 1998

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“…Concomitantemente, elevadas concentrações intracelulares de gliceraldeído podem ser tóxicos para os tecidos, devido a geração de radicais provenientes da oxidação deste composto (Thoranelly et al, 1984). Em doenças como diabetes mellitus, estes efeitos somados ao aumento estresse oxidativo característico desta doença (Godin et al, 1988;Strain, 1991), representa uma questão a ser considerada no planejamento dietético para pacientes diabéticos.…”

Section: Aspectos Metabólicos E Fisiológicos Do Cobreunclassified

“…Existe uma literatura considerável sobre alterações do estado antioxidante em diabetes mellitus (Godin et al, 1988;Strain, 1991). Dentre os nutrientes com funções antioxidantes reconhecidas, destacam-se o zinco, cobre e selênio por serem componentes estruturais de enzimas antioxidantes.…”

Section: Bases Bioquímicas Da Deficiência De Cobreunclassified

Alterações metabólicas e funcionais do cobre em diabetes mellitus

Pedrosa

Cozzolino

1999

Rev. Nutr.

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“…increased free radical production or reduced activity of antioxidant defenses or both. Implication of oxidative stress in the pathogenesis of diabetes is suggested, not only by oxygen free-radical generation, but also due to nonenzymatic protein glycosylation, auto-oxidation of glucose [38], impaired glutathione metabolism [36], alteration in antioxidant enzymes [51], lipid peroxides formation [6] and decreased ascorbic acid levels [56]. In addition to GSH, there are other defense mechanisms against free radicals like the enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) whose activities contribute to eliminate superoxide, hydrogen peroxide and hydroxyl radicals [49].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress in diabetes mellitus

Moussa¹

2015

Integr Obesity Diabetes

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Abstract. Our aim was to evaluate oxidative stress in diabetes mellitus by the measurement of biophysical parameters (changes) of hemoglobin macromolecule and some biochemical parameters on two groups of diabetic patients, non-insulin dependent diabetes mellitus (NIDDM), and insulindependent diabetes mellitus (IDDM). This study has been conducted on 45 NIDDM, 30 IDDM, compared to 20 healthy subjects. Blood glucose, glycosylated hemoglobin (HbA1c), fructosamine, plasma insulin, plasma malondialdehyde (MDA), erythrocyte reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione reductase (GSH-Red) were measured. Also the biophysical parameters, electrical conductivity of hemoglobin, auto-oxidation rate of hemoglobin, and hemoglobin derivatives were measured. Diabetic patients (NIDDM, IDDM) have significant increases in blood glucose, glycosylated (HbA1c), fructosamine with a concomitant significant decrease in Plasma insulin compared to control. Diabetic patients (NIDDM, IDDM) have a significant high level of MDA compared to control. Diabetic patients (NIDDM, IDDM) have a significant increase in SOD activity, and a significant decrease of GSH compared to control. Significant increases in electrical conductivity of Hb, hemoglobin auto-oxidation rate and hemoglobin derivatives in diabetic patient compared to control. IDDM have a higher level of hemoglobin autooxidation rate when compared to NIDDM. Diabetic patients undergo an important oxidative stress that is low in NIDDM compared to IDDM, suggesting metabolic differences between the two types of diabetes. Met-Hb is an important indicator for oxidative stress in diabetes.

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Disturbances of micronutrient and antioxidant status in diabetes

Cited by 130 publications

References 100 publications

Serum antioxidants and risk of non‐insulin dependent diabetes mellitus

Serum antioxidants and risk of non‐insulin dependent diabetes mellitus

Alterações metabólicas e funcionais do cobre em diabetes mellitus

Oxidative stress in diabetes mellitus

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