Disturbances of Pigmentation with Chloroquine

Dall, J. L. C.; Keane, Julia A.

doi:10.1136/bmj.1.5134.1387

Cited by 37 publications

(7 citation statements)

References 7 publications

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“…Chloroquine (CHL) is an antimalarial drug approved by both the Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of lupus erythematosus and rheumatoid arthritis. Lightening on the hair scalp, and less frequently on the eyelashes, eyebrows, moustache and body hair, has been shown to be induced by CHL administered at a dosage starting from 250 mg daily [11][12][13][14][15][16][17][18][19][20][21][22][23]. Hair hypopigmentation (a brightening of any hair colour leading to whitening) occurred from four weeks up to 12 months after treatment initiation, and was reversible after discontinuation or dosage reduction.…”

Section: Drugs That Induce Hair Colour Changes Chloroquinementioning

confidence: 99%

“…Hair hypopigmentation (a brightening of any hair colour leading to whitening) occurred from four weeks up to 12 months after treatment initiation, and was reversible after discontinuation or dosage reduction. Hair hypopigmentation has been also described after hydroxychloroquine administration [24,25], but a revert to normal hair colour occurred when CHL was switched to hydroxychloroquine [15,16,20]. Skin hypopigmented maculae associated with hair depigmentation have been rarely reported [18].…”

Section: Drugs That Induce Hair Colour Changes Chloroquinementioning

confidence: 99%

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Drug-induced hair colour changes

Ricci¹,

Simone²,

Regno³

et al. 2016

European Journal of Dermatology

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Drug-induced hair colour changesHair colour modifications comprise lightening/greying, darkening, or even a complete hair colour change, which may involve the scalp and/or all body hair. Systemic medications may cause hair loss or hypertrichosis, while hair colour change is an uncommon adverse effect. The rapidly increasing use of new target therapies will make the observation of these side effects more frequent. A clear relationship between drug intake and hair colour modification may be difficult to demonstrate and the underlying mechanisms of hair changes are often unknown. To assess whether a side effect is determined by a specific drug, different algorithms or scores (e.g. Naranjo, Karch, Kramer, and Begaud) have been developed. The knowledge of previous similar reports on drug reactions is a key point of most algorithms, therefore all adverse events should be recognised and reported to the scientific community. Furthermore, even if hair colour change is not a life-threatening side effect, it is of deep concern for patient's quality of life and adherence to treatment. We performed a review of the literature on systemic drugs which may induce changes in hair colour.

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Section: Drugs That Induce Hair Colour Changes Chloroquinementioning

confidence: 99%

Section: Drugs That Induce Hair Colour Changes Chloroquinementioning

confidence: 99%

Drug-induced hair colour changes

Ricci¹,

Simone²,

Regno³

et al. 2016

European Journal of Dermatology

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show abstract

“…The effect is temporarily suppressive, like that of corticosteroids, but appears more slowly; and possibly relapse after cessation of treatment which has led to improvement is also slower. The toxic immediate effects include anorexia, nausea and abdominal discomfort, giddiness and tremor, which may be severe enough to put a stop ro treatment in 5-10% of patients; and on long-term treatment bleaehing of hair and temporary photosensitivity (Dall and Keane, 1959), and some potentially serious oeular eomplieations. These include ehanges in the cornea, with white or yellowish linear or punctate deposits eausing blurring of vision and eoloured haloes round bright lights (Hobbs and Calnan, 1958), and retinopathy eausing visual field defeets (Hobbs et al, 1959).…”

Section: Treatmentmentioning

confidence: 99%

Sarcoidosis

Scadding

Mitchell

1985

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“…Dali and Keane suggested the possibility that the chloroquine interferes with deposition of pigment or replaces normal pigment (8). The pigmentary changes which rarely oc cur in the retina, the depigmentation of hair and the involvement of the highly pigmented uveal tract in our case led us also to presume that this drug has an affinity to pigmented tissues.…”

Section: Discussionmentioning

confidence: 77%