Disturbances of spatial vision and object vision correlate differently with regional cerebral glucose metabolism in Alzheimer’s disease

Fujimori, Misato; Imamura, Toru; Hirono, Nobutsugu; Ishii, Kazunari; Sasaki, Masahiro; Mori, Etsuro

doi:10.1016/s0028-3932(00)00060-9

Cited by 36 publications

(19 citation statements)

References 40 publications

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“…In our study, taking an intact approach was associated with higher metabolism in right temporal regions, contrary to the hypothesis that this would correlate with frontal regions involved in planning. The right temporal lobe has been implicated in object recognition (Haxby et al, 1991) and in AD, disturbances in object recognition correlate with right temporal and inferior parietal hypometabolism (Fujimori et al, 2000). Our finding may point to the fact that object recognition is a strong determinant of the approach to copying the figure in AD.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have hypothesized that the association with temporal regions in particular may indicate that successful clock drawing performance requires semantic knowledge about the representation of time. Studies of simple visuoperception in AD have reported an association between perception and right superior parietal lobule integrity (Tippett & Black, 2008) or right temporal-parietal regions (Fujimori et al, 2000). Taken together, the literature suggests that visuospatial dysfunction in AD is largely due to damage of posterior brain regions, with more difficult tasks generally reflecting damage to a more extensive brain network.…”

Section: Discussionmentioning

confidence: 99%

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Association between cerebral metabolism and Rey–Osterrieth Complex Figure Test performance in Alzheimer's disease

Melrose

Harwood

Khoo

et al. 2013

Journal of Clinical and Experimental Neuropsychology

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The copy condition of the Rey-Osterrieth Complex Figure (ROCF) is sensitive to Alzheimer’s disease (AD) pathology, but its neural correlates remain unclear. We used FDG-PET to elucidate this association in 77 patients with probable AD. We observed a correlation between ROCF and metabolic rate of bilateral temporal-parietal cortex and occipital lobe, and right frontal lobe. Global and local elements of the ROCF correlated with metabolic rate of these same regions. The copy approach correlated with right lateral temporal cortex. The ROCF appears reflective of posterior temporal-parietal cortex functioning, highlighting the role of visuospatial processing in constructional abilities in AD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between cerebral metabolism and Rey–Osterrieth Complex Figure Test performance in Alzheimer's disease

Melrose

Harwood

Khoo

et al. 2013

Journal of Clinical and Experimental Neuropsychology

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“…In particular, the impairment in the visual discrimination and the visual counting tasks was more severe in iNPH than in AD patients. Defective performance on the visual discrimination tasks suggests impairment in visual form perception or constructive function [22]. Previously, a constructive deficit in iNPH has been demonstrated using the block design task of the WAIS-R [12].…”

Section: Discussionmentioning

confidence: 99%

“…(6) Visual discrimination (length and size, direction and complex form), overlapping figures, and visual counting tasks [22] for visuoperceptual and visuospatial functions.…”

Section: Methodsmentioning

confidence: 99%

Cognitive Profile of Idiopathic Normal Pressure Hydrocephalus

Saitô

Nishio

Kanno

et al. 2011

Dement Geriatr Cogn Disord Extra

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105

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Background/Aims: Frontal lobe dysfunction is believed to be a primary cognitive symptom in idiopathic normal pressure hydrocephalus (iNPH); however, the neuropsychology of this disorder remains to be fully investigated. The objective of this study was to delineate a comprehensive profile of cognitive dysfunction in iNPH and evaluate the effects of cerebrospinal fluid (CSF) shunt surgery on cognitive dysfunction. Methods: A total of 32 iNPH patients underwent neuropsychological testing of memory, attention, language, executive function, and visuoperceptual and visuospatial abilities. Of these 32 patients, 26 were reevaluated approximately 1 year following CSF shunt surgery. The same battery of tests was performed on 32 patients with Alzheimer’s disease (AD) and 30 healthy elderly controls. Results: The iNPH patients displayed baseline deficits in attention, executive function, memory, and visuoperceptual and visuospatial functions. Impairments of attention, executive function, and visuoperceptual and visuospatial abilities in iNPH patients were more severe than in those with AD, whereas the degree of memory impairment was comparable to that in AD patients. A significant improvement in executive function was observed following shunt surgery. Conclusion: Patients with iNPH are impaired in various aspects of cognition involving both ‘frontal’ executive functions and ‘posterior cortical’ functions. Shunt treatment can ameliorate executive dysfunction.

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“…Visual object recognition deficits are an early sign of AD, and they can be detected in even in amnestic MCI [9,10,11,12] and mild AD patients [23,24,25]. These visuoperceptual deficits worsen with disease progression in AD patients [26], and they are related to CNS perfusion abnormalities in the posterior cingulate, occipital and inferior temporal cortices [11, 27, 28], and the right temporal pole [11].…”

Section: Introductionmentioning

confidence: 99%

A Two-Year Follow-Up of Cognitive Deficits and Brain Perfusion in Mild Cognitive Impairment and Mild Alzheimer's Disease

Alegret

Cuberas-Borrós

Vinyes-Junqué

et al. 2012

JAD

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Background The 15-Objects Test (15-OT) provides useful gradation of visuoperceptual impairment from normal aging through Alzheimer’s disease (AD) and correlates with temporo-parietal perfusion. Objectives To analyse progression of 15-OT performance in Mild Cognitive Impairment (MCI) and AD, and its correlates with cognition and Single Photon Emission Computerized Tomography (SPECT). Further, to examine neuropsychological and SPECT differences between the MCI patients who developed AD and those who didn’t. Methods From the initial 126 participants (42/group), 38AD, 39MCI and 38 elderly controls (EC) were reassessed (SPECT: 35AD, 33MCI, 35EC) after two years. The progression of cognitive and SPECT scores during this period was compared between groups, and baseline data between converters and non-converters. SPECT data were analysed by SPM5. Results The 15-OT was the only measure of progression that differed between the three groups; worsening scores on 15-OT were associated with worsening in verbal and visual retention, and decreased perfusion on left postsubicular area. In the MCI patients cerebral perfusion fell over the two years in medial-posterior cingulate and fronto-temporo-parietal regions; AD showed extensive changes involving almost all cerebral regions. No SPECT changes were detected in controls. At baseline, the MCI patients who developed AD differed from non-converters in verbal recognition memory, but not in SPECT perfusion. Conclusion SPECT and 15-OT appear to provide a potential measure to differenciate between progression of normal aging, MCI and AD. Worsening on 15-OT was related to decreased perfusion in postsubicular area; but further longitudinal studies are needed to determine the contribution of 15-OT as a predictor of AD from MCI.

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Disturbances of spatial vision and object vision correlate differently with regional cerebral glucose metabolism in Alzheimer’s disease

Cited by 36 publications

References 40 publications

Association between cerebral metabolism and Rey–Osterrieth Complex Figure Test performance in Alzheimer's disease

Association between cerebral metabolism and Rey–Osterrieth Complex Figure Test performance in Alzheimer's disease

Cognitive Profile of Idiopathic Normal Pressure Hydrocephalus

A Two-Year Follow-Up of Cognitive Deficits and Brain Perfusion in Mild Cognitive Impairment and Mild Alzheimer's Disease

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