Disturbances of the adrenergic innervation of the stomach in rats with stable control of cardiovascular functions during emotional stress

Krokhina, E. M.; Skotselyas, Y. G.; Yumatov, E. A.

doi:10.1007/bf00801140

Cited by 2 publications

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“…Stress-induced ulceration results from linear ischemic necroses of gastric mucosa caused by vasoconstriction due to enhanced release of catecholamines [2,12]. It was shown that suppressed production of the major vasodilator NO in the stomach (a local stressprotective factor) plays a key role in adrenergic vasoconstriction and ischemic injuries [ 15].…”

Section: Resultsmentioning

confidence: 99%

Differences in behavioral patterns and resistance to stress-induced gastric ulceration between August and Wistar rats adapted and unadapted to hypoxia

et al. 1999

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The incidence of gastric ulceration induced by acute emotional stress in Wistar rats is 3 times higher than in August rats, and the mean number of gastric ulcers in Wistar rats 6.3-fold surpassed that in August rats. Wistar rats predisposed to stress-induced ulceration displayed suppressed locomotor and exploratory activities in the open field test, while August rats had more stable behavioral patterns and enhanced exploratory activity after stress. Short-term preadaptation to hypobaric hypoxia for 6 days attenuated stress-induced gastric ulceration, whereas long-term adaptation (40 days) aggravated the severity of gastric ulcers in August and Wistar rats. The interstrain differences in stress-induced ulceration persisted after adaptation. The data suggest that these differences are related to genetically determined peculiarities of production and metabolism of NO and glucocorticoids in August and Wistar rats. Key Words: August and Wistar Rats; stress; ulcer formation; adaptation; behaviorAugust rats are less resistant to stress-induced damages to the cardiovascular system than Wistar rats, which are assumed to be more resistant to emotional stress [9,13]. However, in stressed August rats the rise in blood concentration of creatine phosphokinase (marker of injuries) is less pronounced [8], and the primary immune response to sheep erythrocytes was greater than in stressed Wistar rats [11]. Therefore, various systems of the body have different genetically determined resistances to stress-induced damages. Here we studied gastric ulceration and behavioral changes induced by emotional stress in August and Wistar rats. The effect of preadaptation to hypobaric hypoxia (AH) possessing protective properties in stress [7] on stressinduced gastric ulceration was assessed. MATERIALS AND METHODSExperiments were performed on 129 male August and Wistar rats weighing 250+30 and 300• g, respectively. In series I, stress-induced formation of gastric ulcers in intact rats and animals adapted to hypobaric hypoxia was studied, In series II, open field (OF) behavior of intact fasted or sated rats and stressed fasted rats was tested [14], The rats deprived of food for 24 h were placed for 30 min into a standard cage (50x30x20 cm) filled with water (22~ 15-cm layer) and covered with a grid (5 cm form water surface) [1]. The total length and area of gastric ulcers were assessed 1 h after stress. The OF behavior of each rat was tested for 4 rain, and the numbers of peripheral and central ambulations (horizontal activity) and peripheral and central rearings with and without support (vertical activity) were recorded. Long-term and shortterm AH were conducted in a hypobaric pressure chamber of the extract-and-influx type. Long-term AH was performed for 1, 2, 3, and 4 h at simulated alti-9

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Section: Resultsmentioning

confidence: 99%

Differences in behavioral patterns and resistance to stress-induced gastric ulceration between August and Wistar rats adapted and unadapted to hypoxia

et al. 1999

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Emotional Stress: The Dialectics of Nature

Yumatov¹

2020

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The article considers the biological nature and origins of emotional stress. Emotional stress is primarily formed within the mental activity of the brain in the form of pronounced negative emotions. The "Dynamic Theory of Emotions" characterizes the development of a continuous negative emotional state in conflicting behavioral situations when the subject is unable to satisfy its strong dominant need for a long time. The emotional stress is represented as having a dual nature, i.e. a biologically negative pathogenetic effect on health, but a positive impact on the adaptation of individuals, self-preservation of life, and evolutionary change in species.

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Disturbances of the adrenergic innervation of the stomach in rats with stable control of cardiovascular functions during emotional stress

Cited by 2 publications

References 5 publications

Differences in behavioral patterns and resistance to stress-induced gastric ulceration between August and Wistar rats adapted and unadapted to hypoxia

Differences in behavioral patterns and resistance to stress-induced gastric ulceration between August and Wistar rats adapted and unadapted to hypoxia

Emotional Stress: The Dialectics of Nature

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