Disturbed release of cholecystokinin in pregnant women with hyperemesis gravidarum

Biberoğlu, Ebru; Kırbaş, Ayşe; İskender, Cantekin; Dirican, Aylin Onder; Dağlar, Halil Korkut; Demirtaş, Canan; Doğanay, Beyza; Uygur, Dilek; Biberoğlu, Kutay

doi:10.1111/jog.12562

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…Nuchal translucency Nuchal translucency was measured and reported in 44 cases: the results were abnormal (>2.5 mm, including cystic hygroma) in 39 cases (88.63%) [1,[10][11][12][13]16,17,22,25,26,[28][29][30][34][35][36]41,[43][44][45][46][47]50,53,54,56,57].…”

Section: Intracardiac Anomaliesmentioning

confidence: 99%

Cantrell syndrome in the first trimester of pregnancy: imagistic findings and literature review

et al. 2020

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Pentalogy of Cantrell (POC) is a rare condition characterized by complete or partial expression of 5 types of congenital birth defects originating in (1) the lower sternum, (2) the anterior diaphragm, (3) the diaphragmatic pericardium, (4) the midline/ventral supraumbilical abdominal wall region, and (5) the heart. POC can be diagnosed antenatally by means of ultrasonography (US), the task being difficult if defects are minor. Advances in the field of US and the introduction of the first morphology trimester as state-of-the-art pregnancy monitoring, facilitate the early diagnosis of this condition. We performed a systematic review on 67 reported cases of POC diagnosed in the first trimester of pregnancy (published from January 1980 to July 2019). The aim of our systematic review was twofold: to assess the main US findings in the first trimester of pregnancy and to increase awareness of early diagnostic possibilities. Our study showed that POC can be diagnosed in the first trimesterof pregnancy based on key US findings such as the association between omphalocele and ectopia cordis. When these two anomalies are present, increased nuchal translucency can also be considered a marker of POC in the first trimester.

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Section: Intracardiac Anomaliesmentioning

confidence: 99%

Cantrell syndrome in the first trimester of pregnancy: imagistic findings and literature review

et al. 2020

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“…Так, имеются указания на повышение его уровня в сыворотке крови пациентов с гастроэзофагеальной рефлюксной болезнью (особенно при сочетании с сахарным диабетом 2-го типа), нарастаю щего с увеличением степени ожир ения [29], а также на понижение его средней концентрации в слизистой оболочке [30]. Рядом авторов обнаруже-но двукратное уменьшение концентрации холецистокинина в сыворотке крови у женщин, страдаю щих рвотой беременных [31].…”

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Pathogenetic role of cholecystokinin in functional dyspepsia

et al. 2022

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Introduction. The high prevalence of functional dyspepsia in the population requires detailing the mechanisms of its development with the definition of the role of hormones of the gastrointestinal tract in the development of clinical symptoms.Purpose of the study: to clarify the pathogenetic role of cholecystokinin in functional dyspepsia.Materials and methods. A prospective examination of 90 people aged 22.3 ± 0.17 years, divided into 3 groups, was carried out: patients with postprandial distress syndrome (PDS), patients with epigastric pain syndrome (EPS), practically healthy. The participants of the study were questioned according to the GSRS questionnaire, their anthropometric data, the concentration of cholecystokinin in the blood before and after the drinking test were determined. Statistical processing included calculation of means, their errors, Mann-Whitney U-test for independent samples and Wilcoxon W-test for related samples, Spearman’s rank correlation test.Results. Patients with EPS are characterized by a statistically significantly greater severity of abdominal pain syndrome (4.33 ± 0.51 points) than those suffering from PDS (2.47 ± 0.38 points) and healthy people (2.19 ± 0.22 points). Dyspeptic syndrome is more typical for patients with PDS (2.07 ± 0.12 points) than those with EPS (1.10 ± 0.04 points). Patients with PDS are characterized by higher values of height, hip volume, lean mass, waist to hip ratio than patients with EPS. The concentration of cholecystokinin in the blood on an empty stomach in patients with EPS (213.37 ± 14.35 pg/ml) is statistically significantly higher than in those examined with PDS (129.45 ± 10.44 pg/ml) and healthy people (146.99 ± 5.17 pg/ml). The level of cholecystokinin in the blood after water exercise in patients with PDS increased statistically significantly to 176.14 ± 8.16 pg/ml, with EPS – decreased to 187.98 ± 7.26 pg/ml. Correlations between the magnitude of cholecystokininemia and the main anthropometric data in EPS and PDS are multidirectional.Conclusion. Cholecystokinin plays an important role in the pathogenesis of gastroduodenal motility disorders in patients with functional dyspepsia.

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“…Biberoğlu ve arkadaşlarının yaptıkları bir çalışmada HG'da, serum CCK (cholecystokinin), sodyum, potasyum ve TSH seviyeleri kontrol grubuna göre düşük saptanırken, serum BUN, fT3 düzeyleri yüksek saptandı. Bununla birlikte serum CCK ve diğer parametreler arasında korelasyon saptanmadı68 .KlinikHG kliniği farklılık gösterse de genel olarak gebeliğin 5-6. Haftasında başlayan, 9. hafta civarında pik yapan ve 16-20.…”

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Hiperemezis Gravidarum

Bülbül¹,

KAPLANOĞLU²,

YILDIRIM³

et al. 2017

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Hyperemesis gravidarum is most commonly seen in the first trimester. Weight loss usually accompanies vomiting and it is less common that the pregnancy-related nausea (0.3-3.6%). Environmental factors and genetic predisposition may play a role in the etiology. Furthermore it is thought that the increased placental load and elevated β-hCG levels also play a role in development of hyperemesis gravidarum. The psychological state of the patient might also aggravate the disease. Hyperemesis gravidarum is diagnosed clinically. This situation will threaten the woman's life besides having potential negative effects on the newborn health if it is not treated properly. The first step of treatment is diet and life style change. Intravenous hydration, electrolyte supplmentation and antiemetics can be used safely and efficiently.

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Disturbed release of cholecystokinin in pregnant women with hyperemesis gravidarum

Abstract: CCK release has been found to be halved in pregnant women with HG, which supports the hypothesis that gastrointestinal motility is increased in pregnant women with HG. A causal effect remains to be confirmed.

Cited by 4 publications

References 47 publications

Cantrell syndrome in the first trimester of pregnancy: imagistic findings and literature review

Cantrell syndrome in the first trimester of pregnancy: imagistic findings and literature review

Pathogenetic role of cholecystokinin in functional dyspepsia

Hiperemezis Gravidarum

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