Disulfide‐Containing Macromolecules for Therapeutic Delivery

Jiang, Ziwen; Thayumanavan, S.

doi:10.1002/ijch.201900160

Cited by 25 publications

(20 citation statements)

References 80 publications

(146 reference statements)

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“…Lately, a lot of efforts have been focused on the development of redox-responsive systems [ 118 , 119 , 120 ]. It is well established that the pathological consequences of inflammation result in the formation of reactive oxygen species (ROS) and other oxidants, causing an oxidative imbalance (stress).…”

Section: Polymer-based Smart Drug Delivery Systems For Topical Applicationsmentioning

confidence: 99%

Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

et al. 2021

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Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

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Section: Polymer-based Smart Drug Delivery Systems For Topical Applicationsmentioning

confidence: 99%

Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

et al. 2021

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“…Therefore, a redox-sensitive targeted nano-drug delivery system has emerged, whose main design feature is the introduction of responsive chemical bonds in the carrier backbone, side chain or crosslinking agent. Moreover, these chemical bonds are relatively stable in the normal environment of the human body including blood and tissue, but they are easy to undergo redox reaction with high concentration of GSH, leading to the cleavage of chemical bonds to release drugs, and achieving accurate delivery of drugs in tumor cells [65,66].…”

Section: Theory Of Redox-sensitive In Nano-drug Delivery Systemmentioning

confidence: 99%

Nano-Drug Design Based on the Physiological Properties of Glutathione

2021

Molecules

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Glutathione (GSH) is involved in and regulates important physiological functions of the body as an essential antioxidant. GSH plays an important role in anti-oxidation, detoxification, anti-aging, enhancing immunity and anti-tumor activity. Herein, based on the physiological properties of GSH in different diseases, mainly including the strong reducibility of GSH, high GSH content in tumor cells, and the NADPH depletion when GSSH is reduced to GSH, we extensively report the design principles, effect, and potential problems of various nano-drugs in diabetes, cancer, nervous system diseases, fluorescent probes, imaging, and food. These studies make full use of the physiological and pathological value of GSH and develop excellent design methods of nano-drugs related to GSH, which shows important scientific significance and prominent application value for the related diseases research that GSH participates in or responds to.

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“…The polymeric networks resulting from linkages between polymer chains can be achieved through various strategies, such as organic, polymerization, quaternization and amidation reactions [ 7 ]. The enhanced stability of cross-linkages, either intramolecular or intermolecular, also represents an important advantage for their application as therapeutic cargo [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Toward Physicochemical and Rheological Characterization of Different Injectable Hyaluronic Acid Dermal Fillers Cross-Linked with Polyethylene Glycol Diglycidyl Ether

et al. 2021

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(1) Background: Injectable hyaluronic acid (HA) dermal fillers are used to restore volume, hydration and skin tone in aesthetic medicine. HA fillers differ from each other due to their cross-linking technologies, with the aim to increase mechanical and biological activities. One of the most recent and promising cross-linkers is polyethylene glycol diglycidyl ether (PEGDE), used by the company Matex Lab S.p.A., (Brindisi, Italy) to create the HA dermal filler PEGDE family. Over the last few years, several studies have been performed to investigate the biocompatibility and biodegradability of these formulations, but little information is available regarding their matrix structure, rheological and physicochemical properties related to their cross-linking technologies, the HA content or the degree of cross-linking. (2) Methods: Seven different injectable HA hydrogels were subjected to optical microscopic examination, cohesivity evaluation and rheological characterization in order to investigate their behavior. (3) Results: The analyzed cross-linked dermal fillers showed a fibrous “spiderweb-like” matrix structure, with each medical device presenting different and peculiar rheological features. Except for HA non cross-linked hydrogel 18 mg/mL, all showed an elastic and cohesive profile. (4) Conclusions: The comparative analysis with other literature works makes a preliminary characterization of these injectable medical devices possible.

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Disulfide‐Containing Macromolecules for Therapeutic Delivery

Cited by 25 publications

References 80 publications

Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Nano-Drug Design Based on the Physiological Properties of Glutathione

Toward Physicochemical and Rheological Characterization of Different Injectable Hyaluronic Acid Dermal Fillers Cross-Linked with Polyethylene Glycol Diglycidyl Ether

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