Disulfide stress in carbon monoxide poisoning

Ergin, Merve; Caliskanturk, Mustafa; Senat, Almila; Aktürk, Onur; Erel, Özcan

doi:10.1016/j.clinbiochem.2016.07.019

Cited by 17 publications

(17 citation statements)

References 29 publications

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“…It has been demonstrated that in patients with carbon monoxide poisoning and smokers NT and TT levels were decrease whereas disulfide level was increased [122,123].…”

Section: Other Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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“…It has been demonstrated that in patients with carbon monoxide poisoning and smokers NT and TT levels were decrease whereas disulfide level was increased [122,123].…”

Section: Other Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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“…An overproduction of oxidized thiolated proteins signifies oxidative stress [8,20]. Alterations to thiol-based redox systems therefore modulate several pathways and are associated with various diseases [9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…Regulation of the thiol-disulfide network is closely related to the alteration of cellular responses [8]. Therefore, thiol-disulfide status has been linked to a growing number of disease pathophysiologies [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus

Ergin

Aydın

Yurt

et al. 2018

Exp Clin Endocrinol Diabetes

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“…Antioxidant and lipid peroxidation were performed using serum samples which kept at -80. The GSH content was measured by Elman s method described previously [16]. Ferric reducing ability/ anti-oxidant power (FRAP) and lipid peroxidation (MDA level) were performed as previously described [17].…”

Section: Antioxidant Content and Lipid-peroxidationmentioning

confidence: 99%