Diterpenes from Annona senegalensis

Assessment of Anti-Fungal Activity of Annona senegalensis Plant Parts on Malassezia globosa

“…The plant is reputed to be of great medicinal value and is used in native medicine [12]. It have been used against snake venom [13,14], for chest pain, coughs, anemia, urinary tract infection [15,16], venereal diseases [17,18], anthritis and rheumatism [19], diarrohea and dysentery [20][21][22], against malaria [23], head and body ache [24,25] anti-bacterial [26], against leishmaniasis [27], against typanasomiasis [28], eyelid swelling [29] Antiprotozoan [30], antitumor agent [31,32], molluscisidal [33] antiulcer/antacid, smooth muscle relaxant [34], anthelmintic activity [35] and also for cancer treatment [17,36]. A lot of scientific studies have been done and reported concerning its medicinal values but none so far on skin ailments caused by the fungus Melassezia globosa.…”

ent-Kaurane Diterpenoids from Annona glabra

“…Comparison of these 13 C NMR chemical shifts with those of the related norkauranoid diterpene 19-norent-kauran-4R-ol-17-oic acid suggested that 4 possesses the same nor-ent-kaurane-type skeleton. 9,11 The typical C-4 at δ 72.2 of norkauranoid diterpene was much different from the kauranoid diterpene in the 13 C NMR spectrum, owing to a hydroxy group attached to C-4. The missing signals for H-16 and the typical proton shift of H-13 suggested the presence of an acetyl group at C-16 and a carbomethoxyl at C-17.…”

“…The 1 H NMR spectrum of 3 displayed methyl singlets at δ 0.99 and 1.20, a pair of doublets at δ 4.04 and 3.67, and two methine protons at δ 2.73 and 3.17, indicating that 3 was probably an ent-kaurane diterpene possessing a carboxylic acid at C-17 and a hydroxy group at C-19. 3,9,11,15,16 The carbons of the ent-kaurane diterpene were assigned, from 13 ., compound 3), we have defined the orientation of H-16 by using the terminology "16R-hydro" or "16 -hydro" to indicate the stereochemistry. 2,3 Annoglabasin F (4) was obtained as a white powder.…”

“…MHz), seeTable 1; EIMS (70 eV) m/z 331(12), 300(9), 272 (3), 233 (17), 123 (23), 109 (32), 91 (44); HRFABMS m/z [M + 1] + 391.2477 (calcd for C23H35O5, 391.2484). Annoglabasin E (16R-hydro-19-ol-ent-kauran-17-oic acid) (3): white powder; mp 206-207°C; [R] 25 D -53.6°(c 0.05, CHCl3 + MeOH); IR (KBr) νmax 3480, 3300, 2940, 2370, 1725, 1230, 1030 cm -1 ; 1 H NMR (C5D5N, 400 MHz)δ 4.04 (1H, d, J ) 10.5 Hz, H-19a), 3.67 (1H, d, J ) 10.5 Hz, H-19b), 3.17 (1H, dt, J ) 12.0, 6.4 Hz, H-16), 2.73 (1H, br s, H-13), 1.20 (3H, s, H-18), 0.99 (3H, s, H-20); 13 C NMR (C5D5N, 100 MHz), see Table 1; EIMS (70 eV) m/z 289 (100), 271 (3), 243 (5), 192 (21), 123 (87), 109 (63), 107 (32), 91 (46); HRFABMS m/z [M + 1] + 321.2415 (calcd for C20H33O3, 321.2430).…”

Chemical composition of the essential oils of Annona cuneata L. and Annona senegalensis Pers. stem barks

“…7 The reported chemical components of A. senegalensis include tannins and free amino acids from the stem bark, 8 ent-kaurenoids from the root bark, 9,10 essential oils from the fruits, 11,15 In addition, the genus Annona in Senegal is known to be used in traditional medicine for the treatment of various illness, the leaves of A. muricata L. are eaten and their decoction is used to cure diabetes and bronchitis. 16 The diverse range of biological activities in Annona led us to investigate the chemical composition of the essential oil from the stem barks of A. cuneata L. and A. senegalensis Pers.…”