Diterpenoids from Fagonia mollis

Abstract

A new acyclic diterpenoid (1) and a new erythroxan diterpenoid (2), together with 4 erythroxan diterpenoids and 3 triterpenoids, have been isolated from the aerial parts of Fagonia mollis. Their structures were elucidated on the basis of 1D and 2D NMR data. The cytotoxic activity of the isolated compounds was investigated against HL-60 cancer cells.

Triterpene saponins from Fagonia scabra Forssk and other Fagonia species

“…A total of forty-nine triterpenoid saponins (1-49) have been identified in the five investigated Fagonia species, F. arabica L. (Miyase et al, 1996a;Shoeb et al, 1994;Perrone et al, 2007), F. cretica L. (Abdel Khalik et al, 2000aBatterjee et al, 2002;Anjum et al, 2014;Saleem et al, 2014), F. glutinosa Delile (Melek et al, 2000), F. indica Burm.f. (Ansari et al, 1987(Ansari et al, , 1988Shaker et al, 1999Shaker et al, , 2000Shaker et al, , 2013Farheen et al, 2015), and F. mollis Delile (Sallam et al, 2014). Their structures are reported in Table 1 and Fig.…”

“…Previous phytochemical studies on Fagonia species demonstrated the presence of flavonoids (Saleh et al, 1990;Al-Wakeel 1992;El-Wakil and Eman, 2007), diterpenoids (Abdel-Kader et al, 1993;Perrone et al 2007;Sallam et al, 2014), sterols glycosides (Shoeb et al 1994), triterpenes (Anjum et al, 2007;Saleem et al, 2014;Farheen et al, 2015) and saponins (Ansari et al, 1988;Miyase et al, 1996a;Melek et al, 2000;Batterjee et al, 2002;Sallam et al, 2014).…”

“…2). Compounds 50-56, were isolated for the first time from the genus with quinovic acid (7) (Sallam et al, 2014). On the other hand three taraxastane saponins were characterized in F. indica (45-46) (Ansari et al, 1987;Farheen et al, 2015) with fagonicin or 3β,20S-dihydroxytaraxastane-28-al and two nahagenin derivatives were isolated from F. arabica (8) (Perrone et al 2007) and F. indica (48) (Ansari et al, 1987).…”

Diterpenes and Their Derivatives as Potential Anticancer Agents

“…The diterpenes from Callicarpa longissima (Liu et al , ), Clerodendrum splendens (Faiella et al , ), Fagonia mollis (Sallam et al , ), Icacina trichantha (Zhao et al , ), Hedychium longipetalum (Zhao et al , ), Micromonospora sp. (Mullowney et al , ), Cespitularia taeniata (Wang et al , ), Caesalpinia spinosa (He et al , ), Nephthea columnaris (Hsiao et al , ), Bursera microphylla (Messina et al , ), Teucrium viscidum (Gao et al , ), Euphorbia ebracteolata (Yuan et al , ), Euphorbia aellenii (Yazdiniapour et al , ), Perenniporia subacida (Wen et al , ), Abies fargesii (Wu et al , ) and Premna tomentosa (Rekha et al , ) were also evident to exert cytotoxic effects on a number of human cancer cell lines.…”

A New Δ-2-Carene-β-D-Glucopyranoside from Fagonia Longispina

“…This genus is present in Algeria with 17 species [2]. Several phytochemical studies of this genus showed the presence of flavonoids [3], diterpenoids [4,5], and triterpenoid saponins [6]. Fagonia longispina Batt.…”