Diterpenoids of terrestrial origin

Abstract

This review covers the isolation and chemistry of diterpenoids from terrestrial as opposed to marine sources and includes labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes and their cyclization products. There are 214 references.

Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)

“…Labdane derivatives exist extensively in terrestrial plants [14], and compounds of this type have also been obtained from various marine organisms, including red algae belonging to the genus Laurencia [15,16,17,18,19]; sponges Chelonaplysilla erecta [20], Raspaciona aculeata [21], Agelas sp. [22]; and nudibranch Austrodoris kerguelensis [23].…”

Three new diterpenoids from Marrubium aschersonii

“…Their fascinating structures and extensive biological activities have attracted broad interests from both natural products and synthetic chemists (Farooq et al, 2015;Hanson, 2015;Markovi c et al, 2015). The genus Marrubium (Lamiaceae) comprising about 40 species is mainly distributed in Europe, North Africa, and Asia (Meyre-Silva and Cechinel-Filho, 2010;Mabberley, 1997).…”

Communic Acids: Occurrence, Properties and Use as Chirons for the Synthesis of Bioactive Compounds

“…Communic acids are a group of diterpenic natural products [1,2,3,4] with a labdane skeleton containing three double bonds and a carboxyl group at position 19 (Figure 1). Five communic acids have been described to date that differ in the location of the double bonds and the orientation of the carboxyl group: trans -communic acid ( 1 ) with the double bonds located in positions 8(17), 12 and 14, with Δ 12 double bond E stereochemistry, and axial carboxyl group orientation, cis -communic acid ( 2 ) the Z isomer of the former, mirceo communic acid ( 3 ), also named iso communic acid, regioisomer of the former, where the Δ 12 double bond moves to Δ 13(16) , 4- epi - trans -communic acid ( 4 ), a C4 epimer of 1 and ent - trans -communic acid ( 5 ) is the (−) enantiomer of 1 .…”