Dithiocarb (N,N‐diethyldithiocarbamate, DEDTC) decreases levels of biogenic monoamines in the adult mouse brain

Abstract

Our data suggest that DEDTC provokes alterations in biogenic amines and in different substrates of neurotransmitter systems, which could explain some of the neurobehavioural effects observed in patients treated with disulphiram.

Design, Synthesis, Characterization and Biological Activities of Novel S‐(Acyloxy)butyl‐N,N‐Diethyldithiocarbamate Compounds

“…Karimov and coworkers declared that diethyldithiocarbamate derivatives exhibited an inhibitory effect on carbonic anhydrases (CA I and CA II), α‐glucosidase, AChE, and BChE enzymes [64] . The study stated that the level of choline acetyltransferase decreased after the dithiocarb treatment in mice compared to control animals [65] . Kumar group reported that administration of natrium diethyl dithiocarbamate trihydrate decreased the level of AChE activities in comparison to the disease control rats in the brain homogenate of experimental animals [66] .…”

“…[64] The study stated that the level of choline acetyltransferase decreased after the dithiocarb treatment in mice compared to control animals. [65] Kumar group reported that administration of natrium diethyl dithiocarbamate trihydrate decreased the level of AChE activities in comparison to the disease control rats in the brain homogenate of experimental animals. [66] When the results of various studies are examined, it is seen that the substances synthesized by our study group are promising molecules in inhibiting the studied enzymes.…”