Diuretic activity and acute oral toxicity of Palicourea coriacea (Cham.) K Schum

Freitas, Paulo C. M.; Pucci, Liuba Laxor; Vieira, Marcelo S.; Junior, Ruyde S. Lino; Oliveira, Cecília Maria Alves de; Cunha, Luíz Carlos da; Paula, José Realino de; Valadares, Marize Campos

doi:10.1016/j.jep.2010.12.002

Cited by 15 publications

(12 citation statements)

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“…V. heterophylla may impair the basal secretion of ADH and reduce the responsiveness of uriniferous tubules to the action of ADH. Inhibition of ADH causes polyurea with low osmolarity [31]. Aldosterone hormone measured by radioimmunoassay was slightly increased in animals treated with aqueous extract, and the lack of correlation between plasma aldosterone and sodium concentration in the blood as well as in urine seem to imply that aldosterone is not involved in the natriuresis observed and suggested that stimulation of diuresis by the aqueous extract of the leaves of V. heterophylla could be similar to that of furosemide.…”

Section: Discussionmentioning

confidence: 99%

Diuretic and antioxidant activities of the aqueous extract of leaves of Vepris heterophylla (Engl.) R. Let (Rutaceae) in rats

Ntchapda

Berthou

Azambou

et al. 2016

BMC Complement Altern Med

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Background Vepris heterophylla (Rutaceae) is a medicinal plant used empirically in African traditional medicine for many clinical conditions including edematous disorders and hypertension. V. heterophylla aqueous extract has been used in northern part of Cameroon by traditional healers for the treatment of arterial hypertension. The study aim was to assess the putative diuretic and antioxidant properties of V. heterophylla leaves aqueous extract.MethodsAdult rats were administered with V. heterophylla leaves aqueous extract acutely (24 h) at doses 50, 100, 150, 200 and 250 mg/kg (per os). The two positive control groups received the diuretic drugs furosemide (5 mg/kg) and hydrochlorothiazide (HCTZ, 10 mg/kg), while negative control group received only an equivalent volume of distilled water. Urinary elimination of electrolytes in response to treatments was evaluated, together with changes in concentrations of creatinine, urea, aldosterone, glucose and albumin in urine and plasma. Various urinary indicators of kidney function and plasmatic markers of oxidative stress were also assessed.ResultsThe findings indicated that the aqueous extract of V. heterophylla at doses ranging from 150 to 250 mg/kg caused a significant and dose-dependent increase of urinary water and electrolytes excretion in normal rats. The aqueous extract of the leaves of V. heterophylla accelerated the elimination of overloaded fluid. At the maximum of diuretic response, urinary osmolarity decreased significantly when compared with controls. Oral administration of aqueous extract at different doses produced a significant diuresis and slight increase in electrolytes (Na+, K+ and Cl−) excretion. The results obtained were compared with standard drug-furosemide (5 mg/kg) and hydrochlorothiazide (10 mg/kg). These effects were observed predominantly at 250 mg/kg dose.ConclusionsOur findings strongly suggest that V. heterophylla aqueous extract has diuretic and antioxidant activities, and deserves further studies considering the potential for the treatment of hypertension.

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Section: Discussionmentioning

confidence: 99%

Diuretic and antioxidant activities of the aqueous extract of leaves of Vepris heterophylla (Engl.) R. Let (Rutaceae) in rats

Ntchapda

Berthou

Azambou

et al. 2016

BMC Complement Altern Med

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“…Although the aerial parts of this plant are commonly used in the form of aqueous preparations for diuresis, there are only a few reports proving their effect in experimental studies. According to Freitas et al [26], the ethanolic extract of the aerial parts of this plant showed a diuretic effect at doses of 20, 40, and 80 mg/kg, as well as an increase in the excretion of Na + and K + in NTR. On the other hand, the ethanolic extract at the dose of 2000 mg/kg did not present toxicity over a 14-day period of daily treatment in NTR, opening up prospects for prolonged pharmaceutical use of this plant.…”

Section: Brazilian Medicinal Plants With Diuretic Potentialmentioning

confidence: 96%

“…Palicourea coriacea (Cham.) K Schum., popularly known as "douradinha-do-campo" and found in the Midwest of Brazil, has been widely used for kidney disorders [26]. Although the aerial parts of this plant are commonly used in the form of aqueous preparations for diuresis, there are only a few reports proving their effect in experimental studies.…”

Section: Brazilian Medicinal Plants With Diuretic Potentialmentioning

confidence: 99%

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

et al. 2020

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Medicinal plants are used in traditional medicine to treat a wide range of ailments. The knowledge of them is handed down from generation to generation and is described in several pharmacopoeia and in the general literature. The immense biodiversity of the Brazilian flora, covering about 25% of all plant species worldwide, makes Brazil a huge potential source of medicinal plants. Indeed, many of these plant species are already used in the Brazilian ethnopharmacology for their probable effect to induce diuresis, to reduce fluid retention, and to treat cardiovascular and renal disorders. This review article describes and discusses the main native Brazilian medicinal plants (including some of their isolated compounds) used as diuretics. It also gives a comprehensive analysis of the most relevant scientific studies presented to date, as well as addressing a special topic with future prospects for plant species that have not yet been scientifically studied. In brief, several plants can be indicated for more detailed study, with a view to obtain scientific subsidies for a new and effective diuretic medicine in the future. These include Bauhinia forficata, Leandra dasytricha, and Tropaeolum majus. Other species have reputed medicinal properties but lack experimental assays to demonstrate their pharmacological effects (e.g., Mikania hirsutissima, Phyllanthus niruri, and Tagetes minuta). Several active principles are indicated as responsible for the diuretic effects of the plants studied, with emphasis on phenolic compounds as flavonoids, phenolic acids, and xanthones. These results should encourage more detailed preclinical, clinical, and phytochemical investigations on Brazilian plants in the future.

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“…Yousefi Ghale-Salimi, Eidi, Ghaemi, and Khavari-Nejad (2018) have performed a comparative study on the effects of taraxasterol (Figure 1) extract (Foster, Tyler, & Tyler, 1999). Freitas et al (2011) have suggested Palicourea coriacea (Cham.) possessed diuretic effects, likely due to the presence of ursolic acid (Freitas et al, 2011).…”

Section: Pentacyclic Triterpenes Against Urolithiasismentioning

confidence: 99%

“…Freitas et al (2011) have suggested Palicourea coriacea (Cham.) possessed diuretic effects, likely due to the presence of ursolic acid (Freitas et al, 2011). Rizvi, Shoeb, Kapil, and Popli (1980) have shown that two pentacyclic triterpenoids, 16α-hydroxy-3-ketoisomultiflorene and 3β-hydroxy-16-ketoisomultiflorene isolated from the aerial parts of Antidesma menasu Miq.…”

Section: Pentacyclic Triterpenes Against Urolithiasismentioning

confidence: 99%

Antiurolithiatic effects of pentacyclic triterpenes: The distance traveled from therapeutic aspects

Lobine

Ahmed

Aschner

et al. 2020

Drug Development Research

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Globally, approximately 12% of the population is inflicted by various types of urolithiasis. Standard treatments are available both to avert and treat urolithiasis, but with significant adverse side effects. Pentacyclic triterpenes represent a group of naturally occurring compounds which holds immense potential as therapeutic for treating kidney stone. This review aims to provide an integrative description on how pentacyclic triterpenes can effectively treat calcium oxalate urolithiasis through various mechanisms such as antioxidant, anti‐inflammatory, diuretic, and angiotensin‐converting enzyme inhibition. Some of the pentacylic triterpenes which shows promising activities include lupeol, oleanolic acid, betulin, and taraxasterol. Moreover, future perspectives in the development of pentacyclic triterpenes in formulations/drugs for urinary stone prevention are highlighted. It is anticipated that compiled information would serve as a scientific baseline to advocate further investigations on the potential of pentacyclic triterpenes in urolithiasis remediation.

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Diuretic activity and acute oral toxicity of Palicourea coriacea (Cham.) K Schum

Abstract: The present study confirmed the ethnopharmacological use of Palicourea coriacea as a diuretic agent in the experimental condition tested here. Additionally, this work supports the importance of the preservation of local knowledge as well as the conservation of Brazilian biodiversity.

Cited by 15 publications

References 10 publications

Diuretic and antioxidant activities of the aqueous extract of leaves of Vepris heterophylla (Engl.) R. Let (Rutaceae) in rats

Diuretic and antioxidant activities of the aqueous extract of leaves of Vepris heterophylla (Engl.) R. Let (Rutaceae) in rats

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

Antiurolithiatic effects of pentacyclic triterpenes: The distance traveled from therapeutic aspects

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